AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAmir M.
dc.contributor.authorHassanein S.I.
dc.contributor.authorAbdel Rahman M.F.
dc.contributor.authorGad M.Z.
dc.contributor.otherClinical Biochemistry Unit
dc.contributor.otherFaculty of Pharmacy and Biotechnology
dc.contributor.otherGerman University in Cairo (GUC)
dc.contributor.otherMain Entrance El-Tagamoa El-Khames
dc.contributor.otherNew Cairo City
dc.contributor.otherCairo
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:48Z
dc.date.available2020-01-09T20:40:48Z
dc.date.issued2018
dc.descriptionScopus
dc.description.abstractDimethylarginine aminodehydrolase (DDAH1) and alanine glyoxylate aminotransferase2 (AGXT2) are two enzymes that contribute in asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) metabolism. Hence they affect production and bioavailability of eNOS-derived nitric oxide (NO) and consequently healthy blood vessels. The major aims of the current study were to investigate the association of genetic variants of AGXT2 rs37369, AGXT2 rs16899974 and DDAH1 rs997251 SNPs with incidence of coronary artery disease (CAD) in Egyptians and to correlate these variants with the serum levels of ADMA and SDMA. The study included 150 subjects; 100 CAD patients and 50 healthy controls. Genotyping was performed by qPCR while the ADMA and SDMA concentrations were assayed by ELISA. Both serum ADMA and SDMA concentrations were significantly higher in CAD patients compared to controls (both p < 0.0001). Genotype distributions for all studied SNPs were significantly different between CAD patients and controls. Carriers of AGXT2 rs37369-T allele (CT + TT genotypes) and AGXT2 rs16899974-A allele (CA + AA genotypes) had 2.4- and 2.08-fold higher risk of having CAD than CC genotype in both SNPs (p = 0.0050 and 0.0192, respectively). DDAH1 rs997251 TC + CC genotypes were associated with 2.3-fold higher risk of CAD than TT genotype (p = 0.0063). Moreover, the AGXT2 rs37369 TT and AGXT2 rs16899974 AA genotypes were associated with the highest serum ADMA and SDMA while DDAH1 rs997251 CC genotype was associated with the highest ADMA. AGXT2 rs37369-T, AGXT2 rs16899974-A, and DDAH1 rs997251-C alleles represent independent risk factors for CAD in the Egyptians. � 2018, Springer Nature B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=14154&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/s11033-018-4407-1
dc.identifier.doiPubMed ID 30284143
dc.identifier.issn3014851
dc.identifier.otherhttps://doi.org/10.1007/s11033-018-4407-1
dc.identifier.otherPubMed ID 30284143
dc.identifier.urihttps://t.ly/j6vED
dc.language.isoEnglishen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofseriesMolecular Biology Reports
dc.relation.ispartofseries45
dc.subjectAlanine glyoxylate aminotransferase 2en_US
dc.subjectAsymmetric dimethylarginineen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectDimethylarginine dimethylaminohydrolaseen_US
dc.subjectNitric oxideen_US
dc.subjectPolymorphismsen_US
dc.subjectSymmetric dimethylarginineen_US
dc.subject6 n,n' dimethylarginineen_US
dc.subjectn(g),n(g) dimethylarginineen_US
dc.subject6 n,n' dimethylarginineen_US
dc.subjectAlanine-glyoxylate transaminaseen_US
dc.subjectamidaseen_US
dc.subjectaminotransferaseen_US
dc.subjectarginineen_US
dc.subjectdimethylargininaseen_US
dc.subjectN,N-dimethylarginineen_US
dc.subjectnitric oxideen_US
dc.subjectadulten_US
dc.subjectAGXT2 geneen_US
dc.subjectalleleen_US
dc.subjectArticleen_US
dc.subjectcardiovascular risken_US
dc.subjectcontrolled studyen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectcorrelation analysisen_US
dc.subjectDDAH 1 geneen_US
dc.subjectEgyptianen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectfemaleen_US
dc.subjectgenetic risken_US
dc.subjectgenetic variabilityen_US
dc.subjectgenotypeen_US
dc.subjecthumanen_US
dc.subjectincidenceen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectquantitative analysisen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectanalogs and derivativesen_US
dc.subjectblooden_US
dc.subjectcase control studyen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectEgypten_US
dc.subjectgenetic variationen_US
dc.subjectgeneticsen_US
dc.subjectmetabolismen_US
dc.subjectmiddle ageden_US
dc.subjectAdulten_US
dc.subjectAmidohydrolasesen_US
dc.subjectArginineen_US
dc.subjectCase-Control Studiesen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectEgypten_US
dc.subjectFemaleen_US
dc.subjectGenetic Variationen_US
dc.subjectGenotypeen_US
dc.subjectHumansen_US
dc.subjectIncidenceen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNitric Oxideen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectTransaminasesen_US
dc.titleAGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptiansen_US
dc.typeArticleen_US
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