Novel membrane sensors for the determination of quetiapine fumarate in plasma and in presence of its related compounds

Abstract

Two sensitive and selective polyvinyl chloride (PVC) matrix membrane sensors were developed and investigated for determination of the cationic drug Quetiapine Fumarate (QTF) in pure form, in plasma and in presence of its two related compounds namely Quetiapine N-oxide and Des-ethanol Quetiapine. The two sensors (Ι and ΙΙ) were developed using sodium tetraphenyl borate as a cation exchanger with dioctyl phthalate (DOP) as a plasticizer. Selective molecular recognition component, β-cyclodextrin (β-CD), was used as ionophore to improve the selectivity of sensor II. The proposed sensors had a linear dynamic range of 1×10-6-1×10-2 mol L-1 for sensor Ι and 1×10-7-1×10-2 mol L-1 for sensor ΙΙ with Nernstian slopes of 27.50±0.45 and 39.85±0.3 mV/decade for sensors I and II, respectively over the pH ranges of 2.5-7. The method was validated according to ICH guidelines. Statistical comparison between the results from the proposed method and the results from the reference HPLC method showed no significant difference regarding the accuracy and precision.