Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | El Tanbouly N. | |
| dc.contributor.author | El Sayed A.M. | |
| dc.contributor.author | Ali Z.Y. | |
| dc.contributor.author | Abdel Wahab S. | |
| dc.contributor.author | El Gayed S.H. | |
| dc.contributor.author | Ezzat, Shahira M | |
| dc.contributor.author | El Senousy A.S. | |
| dc.contributor.author | Choucry M.A. | |
| dc.contributor.author | Abdel-Sattar E. | |
| dc.contributor.other | Department of Pharmacognosy | |
| dc.contributor.other | College of Pharmacy | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | 11562 | |
| dc.contributor.other | Egypt; Department of Biochemistry | |
| dc.contributor.other | National Organization for Drug Control and Research | |
| dc.contributor.other | Giza | |
| dc.contributor.other | 12553 | |
| dc.contributor.other | Egypt; Department of Pharmacognosy | |
| dc.contributor.other | College of Pharmacy | |
| dc.contributor.other | October University for Modern Sciences and Arts | |
| dc.contributor.other | 6th of October12566 | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:26Z | |
| dc.date.available | 2020-01-09T20:41:26Z | |
| dc.date.issued | 2017 | |
| dc.description | Scopus | |
| dc.description | MSA Google Scholar | |
| dc.description.abstract | Flaxseed (Linum usitatissimum L.) is a multipurpose crop with health promoting potential. This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars. The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs) (G9 and G10) were assessed for their antidepressant-like effect in rat model of postpartum depression (PPD) induced by hormone-simulated pregnancy followed by hormone withdrawal and compared to fluoxetine. As compared to control group, administration of G9 and G10 (270 mg/kg/day, p.o) for two weeks during the postpartum period can alleviate anxiety and depressive-like behaviors and biochemical changes in PPD-induced rats. This was confirmed by evaluation of anxiety-like behaviors (elevated plus maze, open field test, and forced swim test tests), in addition to biochemical analysis (brain monoamine oxidase-A, corticosterone level, proinflammatory cytokines, and hippocampal redox state). In conclusion, flaxseed oil of Egyptian cultivars G9 and G10 exhibited significant antidepressant-like effect in rat model of PPD without affecting locomotor activity. At the treatment doses, the antidepressant-like activity of Giza 9 oil is comparable to fluoxetine. � 2017 Nebal El Tanbouly et al. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=130094&tip=sid&clean=0 | |
| dc.identifier.doi | https://doi.org/10.1155/2017/6405789 | |
| dc.identifier.doi | PubMed ID : | |
| dc.identifier.issn | 1741427X | |
| dc.identifier.other | https://doi.org/10.1155/2017/6405789 | |
| dc.identifier.other | PubMed ID : | |
| dc.identifier.uri | https://t.ly/EXwYj | |
| dc.language.iso | English | en_US |
| dc.publisher | Hindawi Limited | en_US |
| dc.relation.ispartofseries | Evidence-based Complementary and Alternative Medicine | |
| dc.relation.ispartofseries | 2017 | |
| dc.subject | amine oxidase (flavin containing) isoenzyme A | en_US |
| dc.subject | antidepressant agent | en_US |
| dc.subject | corticosterone | en_US |
| dc.subject | estradiol benzoate | en_US |
| dc.subject | fluoxetine | en_US |
| dc.subject | interleukin 1beta | en_US |
| dc.subject | interleukin 6 | en_US |
| dc.subject | linoleic acid ethyl ester | en_US |
| dc.subject | linolenic acid | en_US |
| dc.subject | linseed oil | en_US |
| dc.subject | oleic acid | en_US |
| dc.subject | oleic acid ethyl ester | en_US |
| dc.subject | omega 3 fatty acid | en_US |
| dc.subject | palmitic acid ethyl ester | en_US |
| dc.subject | palmitic acid methyl ester | en_US |
| dc.subject | progesterone | en_US |
| dc.subject | stearic acid | en_US |
| dc.subject | tumor necrosis factor | en_US |
| dc.subject | adult | en_US |
| dc.subject | animal experiment | en_US |
| dc.subject | animal model | en_US |
| dc.subject | antidepressant activity | en_US |
| dc.subject | anxiety | en_US |
| dc.subject | Article | en_US |
| dc.subject | biochemical analysis | en_US |
| dc.subject | brain level | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | corticosterone blood level | en_US |
| dc.subject | cultivar | en_US |
| dc.subject | elevated plus maze test | en_US |
| dc.subject | female | en_US |
| dc.subject | forced swim test | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | open field test | en_US |
| dc.subject | oxidation reduction state | en_US |
| dc.subject | postnatal depression | en_US |
| dc.subject | pregnancy | en_US |
| dc.subject | puerperium | en_US |
| dc.subject | rat | en_US |
| dc.title | Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression | en_US |
| dc.type | Article | en_US |
| dcterms.isReferencedBy | (2013) WHO Recommendations On Postnatal Care of the Mother and Newborn, , WHOrganization Geneva WHO, Ed., Geneva, Switzerland; (2000) Diagnostic and Statistical Manual of Mental Disorders, , text rev; Arbabi, L., Baharuldin, M.T.H., Moklas, M.A.M., Fakurazi, S., Muhammad, S.I., Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats (2014) Behavioural Brain Research, 271, pp. 65-71; Fallon, V., Groves, R., Halford, J.C.G., Bennett, K.M., Harrold, J.A., Postpartum Anxiety and Infant-Feeding Outcomes: A Systematic Review (2016) Journal of Human Lactation, 32 (4), pp. 740-758; DeCrescenzo, F., Perelli, F., Armando, M., Vicari, S., Selective serotonin reuptake inhibitors (SSRIs) for post-partum depression (PPD): A systematic review of randomized clinical trials (2014) Journal of AffectiveDisorders, 152-154 (1), pp. 39-44; Orsolini, L., Valchera, A., Vecchiotti, R., Suicide during perinatal period: Epidemiology, risk factors, clinical correlates (2016) Frontiers in Psychiatry, 7; Weigelt, K., Bergink, V., Burgerhout, K.M., Pescatori, M., Wijkhuijs, A., Drexhage, H.A., Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis (2013) Brain, Behavior, Immunity, 29, pp. 147-155; Dowlati, Y., Herrmann, N., Swardfager, W., A meta-analysis of cytokines in major depression (2010) Biological Psychiatry, 67 (5), pp. 446-457; Blackmore, E.R., Groth, S.W., Chen, D.-G., Gilchrist, M.A., O'Connor, T.G., Moynihan, J.A., Depressive symptoms and proinflammatory cytokines across the perinatal period in African American women (2014) Journal of Psychosomatic Obstetrics &gynecology, 35 (1), pp. 8-15; Blackmore, E.R., Moynihan, J.A., Rubinow, D.R., Pressman, E.K., Gilchrist, M., O'Connor, T.G., Psychiatric symptoms and proinflammatory cytokines in pregnancy (2011) Psychosomatic Medicine, 73 (8), pp. 656-663; Schiller, C.E., Meltzer-Brody, S., Rubinow, D.R., The role of reproductive hormones in postpartum depression (2015) CNS Spectrums, 20 (1), pp. 48-59; Su, K.-P., Biological mechanism of antidepressant effect of omega-3 fatty acids: How does fish oil act as a 'mind-body interface (2009) Neurosignals, 17 (2), pp. 144-152; Deacon, G., Kettle, C., Hayes, D., Dennis, C., Tucci, J., Omega 3 polyunsaturated fatty acids and the treatment of depression (2017) Critical Reviews in Food Science and Nutrition, 57 (1), pp. 212-223; Raison, C.L., Miller, A.H., Role of inflammation in depression: Implications for phenomenology, pathophysiology and treatment (2013) Modern Trends in Pharmacopsychiatry, 28, pp. 33-48; Bartram, T., (2013) Bartram's Encyclopedia of Herbal Medicine, , Hachette, London, UK; Decsi, T., Kennedy, K., Sex-specific differences in essential fatty acid metabolism (2011) American Journal of Clinical Nutrition, 94 (6), pp. 1914S-1919S; Appleton, K.M., Rogers, P.J., Ness, A.R., Updated systematic review and meta-analysis of the effects of n-3 long-chain polyunsaturated fatty acids on depressed mood (2010) American Journal of Clinical Nutrition, 91 (3), pp. 757-770; Yates, C.M., Calder, P.C., Ed Rainger, G., Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease (2014) Pharmacology & Therapeutics, 141 (3), pp. 272-282; Su, K.-P., Matsuoka, Y., Pae, C.-U., Omega-3 polyunsaturated fatty acids in prevention of mood and anxiety disorders (2015) Clinical Psychopharmacology AndNeuroscience, 13 (2), pp. 129-137; Vogel, A., (1975) A Textbook of Practical Organic Chemistry, the English Language Book Society and, , Longman, London, UK; Stoffel, E.C., Craft, R.M., Ovarian hormone withdrawalinduced "depression" in female rats (2004) Physiology&Behavior, 83 (3), pp. 505-513; Li, M., Chou, S.-Y., Modeling postpartum depression in rats: Theoretic and methodological issues (2016) Zoological Research, 37 (4), pp. 229-236; Paget, G., Barnes, J., Toxicity tests (1964) Evaluation of Drug Activities: Pharmacometrics, 1, pp. 135-165; Chakravarthi, K.K., Avadhani, R., Narayan, R.S., Effects of Glycyrrhiza glabra root extract on learning and memory in wistar albino rats (2012) Drug Invention Today, 4 (7), pp. 387-390; Walf, A.A., Frye, C.A., The use of the elevated plus maze as an assay of anxiety-related behavior in rodents (2007) Nature Protocols, 2 (2), pp. 322-328; Stout, J.C., Weiss, J.M., An animal model for measuring behavioral responses to anxiogenic and anxiolytic manipulations (1994) Pharmacology Biochemistry & Behavior, 47 (3), pp. 459-465; Lucki, I., The forced swimming test as a model for core and component behavioral effects of antidepressant drugs (1997) Behavioural Pharmacology, 8 (6-7), pp. 523-532; Qu, M., Tang, Q., Li, X., Shen-Qi-Jie-Yu-Fang has antidepressant effects in a rodent model of postpartum depression by regulating the immune organs and subsets of T lymphocytes (2015) Neuropsychiatric Disease and Treatment, 11, pp. 1523-1540; Charles, M., McEwen, J., Tabor, H., Tabor, C., MAO activity in rabbit serum (1977) Methods in Enzymology, 17 (94), pp. 692-698. , H. Tabor and C. W. Tabor, Eds. Academic Press, New York, NY, USA; Dhingra, D., Bhankher, A., Behavioral and biochemical evidences for antidepressant-like activity of palmatine in mice subjected to chronic unpredictable mild stress (2014) Pharmacological Reports, 66 (1), pp. 1-9; Marklund, S., Marklund, G., Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase (1974) European Journal of Biochemistry, 47 (3), pp. 469-474; Aebi, H., Catalase in vitro (1984) Methods in Enzymology, 105, pp. 121-126; Ellman, G.L., Tissue sulfhydryl groups (1959) Archives of Biochemistry and Biophysics, 82 (1), pp. 70-77; Omaye, S.T., Turbull, T.P., Sauberchich, H.C., Selected methods for the determination of ascorbic acid in animal cells, tissues, fluids (1979) Methods in Enzymology, 62 (1), pp. 3-11; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) The Journal of Biological Chemistry, 193, pp. 265-275; Buege, J.A., Aust, S.D., Microsomal lipid peroxidation (1978) Methods in Enzymology, 52, pp. 302-310; Levine, R.L., Garland, D., Oliver, C.N., Determination of carbonyl content in oxidatively modified proteins (1990) Methods in Enzymology, 186, pp. 464-478; Montgomery, H., Dymock, J.F., (1961) Determination of Nitrite in Water, p. 414. , Royal Soc Chemistry Thomas Graham House, Science Park, Milton RD, Cambridge CB4 0WF, Cambs, England; Choi, H.J., Park, S.Y., Kim, S.K., Effect of Seeding Time on Fatty Acid Composition, Oil Contents and Seeds Yield in Flax (2012) Korean Journal of Plant Resources, 25 (6), pp. 700-706; Adunga, W., Labuschangne, M., Association of linseed characters and its variability in different environment (2003) The Journal of Agricultural Science, 14, pp. 285-296; Makni, M., Fetoui, H., Gargouri, N.K., Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in-3 and-6 fatty acids in hypercholesterolemic rats (2008) Food and Chemical Toxicology, 46 (12), pp. 3714-3720; Oomah, B.D., Mazza, G., Effect of dehulling on chemical composition and physical properties of flaxseed (1997) LWT-Food Science and Technology, 30 (2), pp. 135-140; Jakubowica, D., The significance of Prostaglandins in the Premenstrual Syndrome (1983) Premenstrual Syndrome. London: Medical New-Tribune, p. 16; Zarrindast, M.R., Acute Administration of Zn, Mg, Thiamine Improves Postpar-tum depression conditions in mice (2012) Archives of Iranian Medicine, 15 (5), p. 306; Walsh, R.N., Cummins, R.A., The open-field test: A critical review (1976) Psychological Bulletin, 83 (3), pp. 482-504; Nephew, B.C., Bridges, R.S., Effects of chronic social stress during lactation on maternal behavior and growth in rats (2011) Stress, 14 (6), pp. 677-684; He, F., Lupu, D.S., Niculescu, M.D., Perinatal-linolenic acid availability alters the expression of genes related tomemory and to epigenetic machinery, theMecp2 DNA methylation in the whole brain of mouse offspring (2014) International Journal of Developmental Neuroscience, 36, pp. 38-44; Vav�kov�, M., Durackov�, Z., Trebatick�, J., Markers of oxidative stress and neuroprogression in depression disorder (2015) Oxidative Medicine and Cellular Longevity, 2015, p. 12; Kamila, S., Madhav, N., Sarkar, C., Screening of novel polyphyto formulations, a natural remedies for learning and memory enhancing properties in rat (2015) International Journal of Nutrition, Pharmacology, Neurological Diseases, 5 (1), pp. 13-19; Xu, J., Xu, H., Liu, Y., He, H., Li, G., Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain (2015) Psychiatry Research, 225 (3), pp. 509-514; Happe, F., (2011) Why Fold Asperger Syndrome into Autism Spectrum Disorder in the DSM-5, , Simons Foundation Autism Research Initiative News and Opinion; Cheng, C.Y., Pickler, R.H., Perinatal stress, fatigue, depressive symptoms, immune modulation in late pregnancy and one month postpartum (2014) The ScientificWorld Journal, 2014; Pan, Y., Chen, X.-Y., Zhang, Q.-Y., Kong, L.-D., Microglial NLRP3 inflammasome activation mediates IL-1-related inflammation in prefrontal cortex of depressive rats (2014) Brain, Behavior, Immunity, 41 (1), pp. 90-100; Brunton, P.J., Russell, J.A., Douglas, A.J., Adaptive responses of the maternal hypothalamic-pituitary-adrenal axis during pregnancy and lactation (2008) Journal of Neuroendocrinology, 20 (6), pp. 764-776; Brummelte, S., Galea, L.A.M., Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam (2010) Hormones and Behavior, 58 (5), pp. 769-779; McNamara, R.K., Jandacek, R., Rider, T., Tso, P., Cole-Strauss, A., Lipton, J.W., Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: Relationship with central serotonin turnover (2010) Prostaglandins, Leukotrienes and Essential Fatty Acids, 83 (4-6), pp. 185-191; Lukic, I., Mitic, M., Djordjevic, J., Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients (2014) Neuropsychobiology, 70 (1), pp. 1-9; Fetoui, H., Zeghal, N., Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbic acid (2010) Toxicology Letters, 196, p. S53; Ge, L., Zhu, M.-M., Yang, J.-Y., Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression (2015) Pharmacology Biochemistry & Behavior, 131, pp. 77-86; Thomas, J., Garg, M.L., Smith, D.W., Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice (2013) The Journal of Nutritional Biochemistry, 24 (10), pp. 1735-1740; Halliwell, B., Oxidative stress and neurodegeneration: Where are we now (2006) Journal of Neurochemistry, 97 (6), pp. 1634-1658; Gautam, M., Agrawal, M., Gautam, M., Sharma, P., Gautam, A., Gautam, S., Role of antioxidants in generalised anxiety disorder and depression (2012) Indian Journal of Psychiatry, 54 (3), pp. 244-247; Yadav, S., Mitha, K.V., Jeganathan, P.S., Pai, S.R., Ganaraja, B., Omega-3 PUFA as food supplementation improves performance of cognitive parameter in type 1 diabetes mellitus model of wistar rats (2015) Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (5), pp. 1251-1259; Labrousse, V.F., Nadjar, A., Joffre, C., Short-termlong chain Omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice (2012) PLoS ONE, 7 (5); Janssen, C.I.F., Kiliaan, A.J., Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, neurodegeneration (2014) Progress in Lipid Research, 53 (1), pp. 1-17; Dhir, A., Kulkarni, S.K., Nitric oxide andmajor depression (2011) Nitric Oxide: Biology and Chemistry, 24 (3), pp. 125-131; Ren, J., Chung, S.H., Anti-inflammatory effect of-linolenic acid and itsmode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-B and mitogen-activated protein kinase pathways (2007) Journal of Agricultural and Food Chemistry, 55 (13), pp. 5073-5080; Lu, Y.-R., Fu, X.-Y., Shi, L.-G., Decreased plasma neuroactive amino acids and increased nitric oxide levels in melancholic major depressive disorder (2014) BMC Psychiatry, 14 (1); Behr, G.A., Moreira, J.C.F., Frey, B.N., Preclinical and clinical evidence of antioxidant effects of antidepressant agents: Implications for the pathophysiology of major depressive disorder (2012) Oxidative Medicine and Cellular Longevity, 2012, p. 13 | |
| dcterms.source | Scopus |