Adiponectin and E-selectin concentrations in relation to inflammation in obese type 2 diabetic patients with coronary heart disease(s)

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Mesallamy H.O.
dc.contributor.authorHamdy N.M.
dc.contributor.authorSalman T.M.
dc.contributor.authorMahmoud S.
dc.contributor.otherBiochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAL-Azhar University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Modern Sciences and Arts University
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:30Z
dc.date.available2020-01-25T19:58:30Z
dc.date.issued2011
dc.descriptionScopus
dc.description.abstractAim. Adipose tissue is now regarded as a source of proinflammatory mediators which may contribute to vascular injury, insulin resistance (IR), and atherogenesis, however, some of them have a protective role against vascular inflammation and/or IR; namely adiponectin and nitric oxide (NO). Adiponectin is a fat derived hormone, which enhances insulin sensitivity. In experimental studies adiponectin was shown to have anti-atherogenic properties by suppressing endothelial expression of adhesion molecules as endothelial-selectin (E-selectin) and inflammatory cytokines as high-sensitivity C-reactive protein (hsCRP), interleukin-1? (IL-1?), and monocyte chemotactic protein-1 (MCP-1). Therefore, the aim of the study was to evaluate plasma adiponectin, E-selectin, hsCRP, IL-1?, and MCP-1 concentrations in obese patients with and without coronary heart disease (CHD) having type 2 diabetes mellitus (DM) and evaluation of their relationship with selected anthropometric, biochemical, and clinical parameters. Methods. The study group consisted of (N.=70) males, 20 of which served as healthy non-obese controls (group I) (mean age 38.53.7 years; mean BMI 28 1.2 kg/m2). Patients enrolled in the study were classified into the following groups: type 2 DM obese subjects without CHD (group II) (N.=25) (mean age 42.23 years; mean BMI 32.11.4 kg/m2) and type 2 DM obese subjects with CHD (group III) (N.=25) (mean age 40.63 years; mean BMI 31.51.2 kg/m 2). Glucose and insulin estimation was performed and insulin resistance index (HOMA-IR) was calculated. In the fasting state, the plasma HbA1c, adiponectin, E-selectin, in comparison to hsCRP, IL-1?, MCP-1, and lipid parameters were estimated. Results. FBG, HbA 1c%, lipids, insulin, MDA, NO, hsCRP, IL-?, MCP-1, Adiponectin as well as E-selectin concentration were significantly different in patients with type 2 DM and CHD in comparison to patients without CHD and moreover, the healthy control group (P=0.01). There was a significant negative correlation between adiponectin and E-selectin (r=-0.642; P=0.0001). Conclusion. Our study supports the hypothesis that decreased level of adipokine(s), together with increased oxidative stress, pro-inflammatory marker(s) as well as endothelial adhesion molecule(s) contributes to the complex process of atherosclerosis in type 2 diabetic obese patients that may lead eventually to CHD.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=26205&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn3911977
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/ge8g8
dc.language.isoEnglishen_US
dc.relation.ispartofseriesMinerva Endocrinologica
dc.relation.ispartofseries36
dc.subjectAdiponectinen_US
dc.subjectCoronary diseasesen_US
dc.subjectDiabetes mellitusen_US
dc.subjectObesityen_US
dc.subjectadiponectinen_US
dc.subjectC reactive proteinen_US
dc.subjectendothelial leukocyte adhesion molecule 1en_US
dc.subjectglucoseen_US
dc.subjecthemoglobin A1cen_US
dc.subjectinsulinen_US
dc.subjectinterleukin 1betaen_US
dc.subjectlipiden_US
dc.subjectmonocyte chemotactic protein 1en_US
dc.subjectnitric oxideen_US
dc.subjectadipose tissueen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectatherogenesisen_US
dc.subjectatherosclerosisen_US
dc.subjectblood vessel injuryen_US
dc.subjectcontrolled studyen_US
dc.subjectdiabetic obesityen_US
dc.subjectdisease associationen_US
dc.subjectglucose blood levelen_US
dc.subjecthumanen_US
dc.subjectinflammationen_US
dc.subjectinsulin resistanceen_US
dc.subjectinsulin sensitivityen_US
dc.subjectischemic heart diseaseen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectnon insulin dependent diabetes mellitusen_US
dc.subjectoxidative stressen_US
dc.subjectvasculitisen_US
dc.subjectAdiponectinen_US
dc.subjectAdulten_US
dc.subjectAlgorithmsen_US
dc.subjectBiological Markersen_US
dc.subjectBody Mass Indexen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectCase-Control Studiesen_US
dc.subjectChemokine CCL2en_US
dc.subjectCoronary Diseaseen_US
dc.subjectDiabetes Mellitus, Type 2en_US
dc.subjectE-Selectinen_US
dc.subjectGlucose Intoleranceen_US
dc.subjectHumansen_US
dc.subjectInflammationen_US
dc.subjectInsulin Resistanceen_US
dc.subjectInterleukin-1betaen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectObesityen_US
dc.subjectPredictive Value of Testsen_US
dc.subjectSensitivity and Specificityen_US
dc.titleAdiponectin and E-selectin concentrations in relation to inflammation in obese type 2 diabetic patients with coronary heart disease(s)en_US
dc.typeArticleen_US
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