Simultaneous determination of carbinoxamine, pholcodine, and ephedrine in antitussive preparation by high-performance liquid chromatography and thin-layer chromatography-densitometry

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMoustafa A.A.
dc.contributor.authorSalem H.
dc.contributor.authorHegazy M.
dc.contributor.authorMahmoud O.A.
dc.contributor.otherAnalytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr-El Aini Street
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherDeraya University
dc.contributor.otherCairo
dc.contributor.other14511
dc.contributor.otherEgypt; Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.other6th October City
dc.contributor.other11787
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:00Z
dc.date.available2020-01-09T20:42:00Z
dc.date.issued2015
dc.descriptionScopus
dc.description.abstractSimple, accurate, precise, sensitive, and validated high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric methods were developed for the simultaneous determination of carbinoxamine (CAR), pholcodine (PHL), and ephedrine (EPH) in antitussive syrup. In method A, reversed-phase (RP)-HPLC analysis was performed on an Inertsil CN-3 column (250 mm � 4.6 mm, 5 ?m), using a mobile phase consisting of acetonitrile-distilled water (pH 3.5) using orthophosphoric acid in the ratio 70:30 (v/v) and flow rate of 1.5 mL min-1. Quantitation was achieved with ultraviolet (UV) detection at 220 nm. In method B, TLC analysis was carried out on an aluminum-backed sheet of silica gel 60 F254 layer using chloroform- propanol-ammonia (6:4:0.1, v/v) as the mobile. Quantification was carried out with UV detection at 245 nm. The validation of the proposed methods was applied according to the International Conference on Harmonization (ICH) guidelines. The suggested methods were successfully applied for the determination of the cited drugs in bulk powder and commercial dosage form. � Akad�miai Kiad�, Budapest.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24059&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1556/1006.2015.28.4.7
dc.identifier.doiPubMed ID :
dc.identifier.issn9334173
dc.identifier.otherhttps://doi.org/10.1556/1006.2015.28.4.7
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/kNxZA
dc.language.isoEnglishen_US
dc.publisherAkademiai Kiado Rt.en_US
dc.relation.ispartofseriesJournal of Planar Chromatography - Modern TLC
dc.relation.ispartofseries28
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectCarbinoxamineen_US
dc.subjectEphedrineen_US
dc.subjectPholcodineen_US
dc.subjectReversed-phase high-performance liquid chromatographyen_US
dc.subjectThin-layer chromatography-densitometryen_US
dc.subjectChromatographyen_US
dc.subjectDrug dosageen_US
dc.subjectHigh performance liquid chromatographyen_US
dc.subjectLiquidsen_US
dc.subjectOrthophosphoric aciden_US
dc.subjectSilica gelen_US
dc.subjectThin layer chromatographyen_US
dc.subjectCarbinoxamineen_US
dc.subjectDensitometric methoden_US
dc.subjectEphedrineen_US
dc.subjectInternational conference on harmonizationsen_US
dc.subjectPholcodineen_US
dc.subjectReversed phase high performance liquid chromatographyen_US
dc.subjectSimultaneous determinationsen_US
dc.subjectUltraviolet detectionen_US
dc.subjectLiquid chromatographyen_US
dc.subjectantitussive agenten_US
dc.subjectcarbinoxamineen_US
dc.subjectephedrineen_US
dc.subjectpholcodineen_US
dc.subjectArticleen_US
dc.subjectcomparative studyen_US
dc.subjectcontrolled studyen_US
dc.subjectdensitometeren_US
dc.subjectdensitometryen_US
dc.subjectdrug determinationen_US
dc.subjectflow rateen_US
dc.subjectlimit of detectionen_US
dc.subjectlimit of quantitationen_US
dc.subjectliquid chromatographen_US
dc.subjectmeasurement accuracyen_US
dc.subjectreproducibilityen_US
dc.subjectreversed phase high performance liquid chromatographyen_US
dc.subjectthin layer chromatographyen_US
dc.subjectultraviolet radiationen_US
dc.titleSimultaneous determination of carbinoxamine, pholcodine, and ephedrine in antitussive preparation by high-performance liquid chromatography and thin-layer chromatography-densitometryen_US
dc.typeArticleen_US
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