Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorSaadeldin M.K.
dc.contributor.authorElshaer S.S.
dc.contributor.authorEmara I.A.
dc.contributor.authorMaged M.
dc.contributor.authorAbdel-Aziz A.K.
dc.contributor.otherDepartment of Biochemistry
dc.contributor.otherFaculty of Pharmacy (Girls)
dc.contributor.otherAl-Azhar University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Biochemistry
dc.contributor.otherNational Institute of Diabetes and Endocrinology (NIDE)
dc.contributor.otherCairo
dc.contributor.otherEgypt; Faculty of Biotechnology
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.other6th October City
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Experimental Oncology
dc.contributor.otherEuropean Institute of Oncology
dc.contributor.otherMilan
dc.contributor.otherItaly
dc.date.accessioned2020-01-09T20:40:50Z
dc.date.available2020-01-09T20:40:50Z
dc.date.issued2018
dc.descriptionScopus
dc.description.abstractDiabetes mellitus represents a major independent risk factor for developing fatal cardiovascular diseases (CVDs) presumably through accelerating atherosclerosis; the underlying cause of most CVDs. Notably, this relative risk is reported to be higher in women than men. Endeavors directed towards identifying novel reliable predictive biomarkers are immensely thereby urged to improve the long-term outcome in these diabetic female patients. Sclerostin (SOST) is a Wnt signaling antagonist whereas irisin is a muscle-derived factor released after exercising which enhances browning of white adipose tissue. Emerging lines of evidence hint at potential crosstalk between them and CVDs. The present study aimed to assess the serum levels of SOST and irisin in Egyptian type 2 diabetic (T2DM) female patients with and without atherosclerosis and explore the possible relationship between both markers and other studied parameters among the studied cohorts. In this case-control study, 69 female subjects were enrolled; 39 type 2 diabetes patients with atherosclerosis (T2DM+ATHR), 22 type 2 diabetes patients without atherosclerosis (T2DM-ATHR) and 8 healthy controls. Their serum levels of SOST and irisin were assessed using ELISA. Significant increase in SOST levels were found in T2DM+ATHR compared to T2DM-ATHR and control (259.9 �17.98 vs. 165.8�13.12 and 142.0�13.31 pg/mL respectively, P0.001). Conversely, irisin levels were significantly lower in T2DM+ATHR (P0.001) and T2DM-ATHR (P0.01) compared to the control group (32.91�2.545 and 58.55�13.19 vs. 473.6�112.7 pg/ mL). Interestingly, significant correlations between the levels of SOST and both irisin and fasting blood glucose were noticed in T2DM+ATHR group (r = 0.3754 and 0.3381 respectively, P0.05). In conclusion, to the best of our knowledge, this study is the first to demonstrate the correlation between SOST and irisin levels in atherosclerotic T2DM female patients implying their potential implication in diabetic cardiovascular pathophysiology and supporting their use as reliable diagnostic/prognostic biomarkers for monitoring and preventing CVDs progression of T2DM female patients. � 2018 Saadeldin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=10600153309&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0206761
dc.identifier.doiPubMed ID 30403705
dc.identifier.issn19326203
dc.identifier.otherhttps://doi.org/10.1371/journal.pone.0206761
dc.identifier.otherPubMed ID 30403705
dc.identifier.urihttps://t.ly/rx6Nn
dc.language.isoEnglishen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofseriesPLoS ONE
dc.relation.ispartofseries13
dc.subjectcholesterolen_US
dc.subjectglucoseen_US
dc.subjecthemoglobin A1cen_US
dc.subjecthigh density lipoprotein cholesterolen_US
dc.subjectinsulinen_US
dc.subjectirisinen_US
dc.subjectlow density lipoprotein cholesterolen_US
dc.subjectoral antidiabetic agenten_US
dc.subjectsclerostinen_US
dc.subjecttriacylglycerolen_US
dc.subjectbiological markeren_US
dc.subjectbone morphogenetic proteinen_US
dc.subjectfibronectinen_US
dc.subjectFNDC5 protein, humanen_US
dc.subjectSOST protein, humanen_US
dc.subjectadulten_US
dc.subjectage distributionen_US
dc.subjectArticleen_US
dc.subjectatherosclerosisen_US
dc.subjectbody massen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcardiovascular risken_US
dc.subjectcase control studyen_US
dc.subjectcholesterol blood levelen_US
dc.subjectclinical assessmenten_US
dc.subjectcohort analysisen_US
dc.subjectcontrolled studyen_US
dc.subjectdiabetic patienten_US
dc.subjectdisease durationen_US
dc.subjectdisease exacerbationen_US
dc.subjectEgyptianen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectfemaleen_US
dc.subjectglucose blood levelen_US
dc.subjecthemoglobin blood levelen_US
dc.subjecthomeostasis model assessmenten_US
dc.subjecthumanen_US
dc.subjectinsulin blood levelen_US
dc.subjectinsulin resistanceen_US
dc.subjectlipid analysisen_US
dc.subjectmajor clinical studyen_US
dc.subjectmolecular interactionen_US
dc.subjectnon insulin dependent diabetes mellitusen_US
dc.subjectpredictive valueen_US
dc.subjectsystolic blood pressureen_US
dc.subjecttriacylglycerol blood levelen_US
dc.subjectatherosclerosisen_US
dc.subjectblooden_US
dc.subjectcomplicationen_US
dc.subjectEgypten_US
dc.subjectgenetic markeren_US
dc.subjectmiddle ageden_US
dc.subjectnon insulin dependent diabetes mellitusen_US
dc.subjectobesityen_US
dc.subjectprognosisen_US
dc.subjectreceiver operating characteristicen_US
dc.subjectAdulten_US
dc.subjectAtherosclerosisen_US
dc.subjectBiomarkersen_US
dc.subjectBone Morphogenetic Proteinsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectCohort Studiesen_US
dc.subjectDiabetes Mellitus, Type 2en_US
dc.subjectEgypten_US
dc.subjectFemaleen_US
dc.subjectFibronectinsen_US
dc.subjectGenetic Markersen_US
dc.subjectHumansen_US
dc.subjectMiddle Ageden_US
dc.subjectObesityen_US
dc.subjectPrognosisen_US
dc.subjectROC Curveen_US
dc.titleSerum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control studyen_US
dc.typeArticleen_US
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