Pomegranate peel attenuates aluminum-induced hepatorenal toxicity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAbdel Moneim A.E.
dc.contributor.authorOthman M.S.
dc.contributor.authorMohmoud S.M.
dc.contributor.authorEl-Deib K.M.
dc.contributor.otherDepartment of Zoology and Entomology
dc.contributor.otherFaculty of Science
dc.contributor.otherHelwan University
dc.contributor.other11795 Helwan
dc.contributor.otherCairo
dc.contributor.otherEgypt; Biochemistry and Molecular Biology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Science and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Zoology
dc.contributor.otherFaculty of Science
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Molecular Drug Evaluation Department
dc.contributor.otherNational Organization for Drug Control and Research (NODCAR)
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:23Z
dc.date.available2020-01-09T20:42:23Z
dc.date.issued2013
dc.descriptionScopus
dc.description.abstractThe present study was undertaken to determine the potential role of methanolic extract of pomegranate peel (MEPP) in modulating aluminum chloride (AlCl3) induced hepatorenal toxicity in female rats. The effect of MEPP (200mg/kgbwt) on AlCl3 (34mg/kgbwt) induced hepatorenal toxicity, accumulation of aluminum (Al), hepatorenal functions and oxidant/antioxidant status of liver and kidney were determined. The changes of liver and kidney structures were investigated with hematoxyline and eosin, in addition, the anti-apoptotic effect of MEPP was analyzed by immunohistochemistry. The present study showed an indication of carcinogenicity in the AlCl3 treated group represented by an increase in tumor necrosis factor-? and angiogenin and inflammation by inducing an increase in prostaglandin E2 and F2?. MEPP protected liver and kidney through reduce the Al accumulation, stimulated antioxidant activities and elevated the anti-apoptotic protein namely Bcl-2. Therefore, these results indicated that the methanolic extract of pomegranate peel has beneficial influences and could be able to inhibit Al-induced oxidative stress and histopathological alternations in liver and kidney of female rats, and these effects may be related to anti-apoptotic and antioxidant activities. � 2013 Informa Healthcare USA, Inc.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=25241&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.3109/15376516.2013.823634
dc.identifier.doiPubMed ID 23837566
dc.identifier.issn15376516
dc.identifier.otherhttps://doi.org/10.3109/15376516.2013.823634
dc.identifier.otherPubMed ID 23837566
dc.identifier.urihttps://t.ly/LXM3X
dc.language.isoEnglishen_US
dc.relation.ispartofseriesToxicology Mechanisms and Methods
dc.relation.ispartofseries23
dc.subjectAluminum chlorideen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectOxidant/antioxidant statusen_US
dc.subjectPomegranate peelen_US
dc.subjectaluminum chlorideen_US
dc.subjectangiogeninen_US
dc.subjectmethanolen_US
dc.subjectpomegranate extracten_US
dc.subjectpomegranate peel extracten_US
dc.subjectprostaglandin E2en_US
dc.subjectprostaglandin F2 alphaen_US
dc.subjectprotein bcl 2en_US
dc.subjecttumor necrosis factor alphaen_US
dc.subjectunclassified drugen_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantioxidant activityen_US
dc.subjectarticleen_US
dc.subjectcarcinogenicityen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectinflammationen_US
dc.subjectkidneyen_US
dc.subjectliveren_US
dc.subjectliver toxicityen_US
dc.subjectnephrotoxicityen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectpomegranateen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectsolvent extractionen_US
dc.subjectAluminumen_US
dc.subjectAnimalsen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectPunicaceaeen_US
dc.subjectRatsen_US
dc.titlePomegranate peel attenuates aluminum-induced hepatorenal toxicityen_US
dc.typeArticleen_US
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