Evaluation of the phytochemical, antioxidant, antibacterial and anticancer activity of Prunus domestica fruit
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | El-Beltagi H.S. | |
| dc.contributor.author | El-Ansary A.E. | |
| dc.contributor.author | Mostafa M.A. | |
| dc.contributor.author | Kamel T.A. | |
| dc.contributor.author | Safwat G. | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Faculty of Agriculture | |
| dc.contributor.other | Biochemistry Department | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Cairo University | |
| dc.contributor.other | Research Park (CURP) | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; October University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | Faculty of Biotechnology | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:40:44Z | |
| dc.date.available | 2020-01-09T20:40:44Z | |
| dc.date.issued | 2019 | |
| dc.description | Scopus | |
| dc.description | MSA Google Scholar | |
| dc.description.abstract | Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There are numerous interests in natural antioxidants extracted from medicinal plants, vegetables and fruits, which might help to prevent oxidative damage. One of such plants is plum Prunus domestica L., family Rosaceae. Samples from 'African Rose', and 'Santa Rosa' plum cultivars were collected from local market in Giza governorate, Egypt. The main phytochemicals of plums (fruit flesh and skin) were analyzed. Total polyphenols, flavonoids, tannins, anthocyanins, and reducing power were higher in 'African Rose' fruit. The ethanolic and ethyl acetate extracts of two plum cultivars were both high in the antioxidant effect with IC50 13.923 and 18.416 ?g/ml of ethanolic extract of 'African Rose', and 'Santa Rosa' respectively. The IC50 of 'African Rose' and 'Santa Rose' extract against Caco-2 was 4 and 8.5 ?g/ml. GC-MS analysis was carried out, fourteen and twenty one compound were identified in 'Santa Rosa' and 'African Rose' respectively. The fruits had an antimicrobial action against gram positive and negative bacteria. There was anticancer activity against 3 cell lines: Liver cell line (HepG2), colorectal adenocarcinoma (Caco-2) cell line, and breast cell line (MCF-7). � 2018. | en_US |
| dc.identifier.doi | https://doi.org/10.15835/nbha47211402 | |
| dc.identifier.doi | PubMedID | |
| dc.identifier.issn | 0255965X | |
| dc.identifier.other | https://doi.org/10.15835/nbha47211402 | |
| dc.identifier.other | PubMedID | |
| dc.identifier.uri | https://t.ly/EXXMK | |
| dc.language.iso | English | en_US |
| dc.publisher | Academic Press | en_US |
| dc.relation.ispartofseries | Notulae Botanicae Horti Agrobotanici Cluj-Napoca | |
| dc.relation.ispartofseries | 47 | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | University of Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | Antibacterial | en_US |
| dc.subject | Anticancer activity | en_US |
| dc.subject | Antioxidant | en_US |
| dc.subject | DPPH | en_US |
| dc.subject | Flavonoid | en_US |
| dc.subject | Phenols | en_US |
| dc.subject | Plum extract | en_US |
| dc.title | Evaluation of the phytochemical, antioxidant, antibacterial and anticancer activity of Prunus domestica fruit | en_US |
| dc.type | Article | en_US |
| dcterms.isReferencedBy | Abdel-Rahim, E.A., El-Beltagi, H.S., Constituents of apple, parsley and lentil edible plants and their therapy treatments for blood picture as well as liver and kidneys functions against lipidemic disease (2010) Electronic Journal of Environmental, Agricultural and Food Chemistry, 9 (6), pp. 1117-1127; Ateya, A.M., Abou-Hashem, M., El-Sayed, Z., Abbas, F., Biological activity of the Egyptian medicinal plants: part 4 Cytotoxicity of 50 Egyptian plants and spices against hepatocellular carcinoma (2014) Journal of Ethnomedicine, 1, pp. 56-63; Bagavathi, P.E., Ramasamy, N., GC-MS analysis of phytocomponents in the ethanol extract of Polygonum chinense L (2012) Pharmacognosy Research, 4 (1), pp. 11-14; Bauer, A.W., Kirby, W.M., Sherris, J.C., Turck, M., Antibiotic susceptibility test-ing by a standardized single disk method (1966) American Journal of Clinical Pathology, 45 (4), pp. 493-496; Cai, Y., Luo, Q., Sun, M., Corke, H., Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer (2004) Life Sciences, 74 (17), pp. 2157-2184; Celep, E., Aydin, A., Yesilada, E., A comparative study on the in vitro antioxidant potentials of three edible fruits: Cornelian cherry, Japanese persimmon and cherry laurel (2012) Food and Chemical Toxicology, 50 (9), pp. 3329-3335; Celik, F., Gundogdu, M., Alp, S., Muradoglu, F., Ercisli, S., Gecer, M.K., Canan, I., Determination of phenolic compounds, antioxidant capacity and organic acids contents of Prunus domestica L., Prunus cerasifera Ehrh. and Prunus spinosa L. fruits by HPLC (2017) Acta Chromatographica, 29 (4), pp. 507-510; Chai, Q., Wu, B., Liu, W., Wang, L., Yang, C., Wang, Y., Fang, J., Li, S., Volatiles of plums evaluated by HSSPME with GC-MS at the germplasm level (2012) Food Chemistry, 130 (2), pp. 432-440; Chou, H.J., Kuo, J.T., Lin, E.S., Comparative antioxidant properties of water extracts from different parts of beefsteak plant (Perilla frutescens) (2009) Journal of Food and Drug Analysis, 17 (6), pp. 489-496; Coelho, E., Rocha, S.M., Delgadillo, I., Coimbra, M.A., Headspace-SPME applied to varietal volatile compounds evolution during Vitis vinifera L. cv 'Baga' ripening (2006) Analytica Chimica Acta, 563 (1-2), pp. 204-214; Costa, J.G.M., Leite, G.O., Dubois, A.F., Seeger, R.L., Boligon, A.A., Athayde, M.L., Campos, A.R., Rocha, J.B.T., Antioxidant effect of Stryphnodendron rotundifolium Martius extracts from Cariri-Cear� state (Brazil): Potential involvement in its therapeutic use (2012) Molecules, 17 (1), pp. 934-950; Cuvelier, M.E., Richard, H., Berset, C., Comparison of the antioxidative activity of some acid-phenols: Structure activity relationships (1992) Bioscience, Biotechnology, and Biochemistry, 56 (2), pp. 324-325; Dai, J., Mumper, R.J., Plant phenolics: extraction, analysis and their antioxidant and anticancer properties (2010) Molecules, 15 (10), pp. 7313-7352; Demir, S., Turan, I., Demir, F., Ayazoglu Demir, E., Aliyazicioglu, Y., Cytotoxic effect of Laurocerasus officinalis extract on human cancer cell lines (2017) Marmara Pharmaceutical Journal, 21, pp. 121-126; Dhingra, N., Sharma, R., Kar, A., Evaluation of the antioxidant activities of Prunus domestica whole fruit: an in vitro study (2014) International Journal of Pharmacy and Pharmaceutical Sciences, 6, pp. 271-276; D�az-Mula, H.M., Zapata, P.J., Guill�n, F., Mart�nez-Romero, D., Castillo, S., Serrano, M., Valero, D., Changes in hydrophilic and lipophilic antioxidant activity and related bioactive compounds during postharvest storage of yellow and purple plum cultivars (2009) Postharvest Biology and Technology, 51 (3), pp. 354-363; Djeridane, A., Yousfi, M., Nadjemi, B., Boutassouna, D., Stocker, P., Vidal, N., Antioxidant activity of some algerian medicinal plants extracts containing phenolic compounds (2006) Food Chemistry, 97 (4), pp. 654-660; Dugalic, K., Sudar, R., Viljevac, M., Josipovic, M., Cupic, T., Sorbitol and sugar composition in plum fruits influenced by climatic conditions (2014) Journal of Agricultural Science and Technology, 16 (5), pp. 1145-1155; Eivind, V., Rune, S.S., Methods to determine antioxidative capacity in fruit (2006) Journal of Fruit and Ornamental Plant Research, 14, pp. 123-131; El-Beltagi, H.E.S., Effect of roasting treatments on protein fraction profiles, some enzyme activities of Egyptian peanuts (2011) International Journal of Food Science and Nutrition, 62 (5), pp. 453-456; El-Beltagi, H.S., Mohamed, H.I., Megahed, B.M.H., Gamal, M., Safwat, G., Evaluation of some chemical constituents, antioxidant, antibacterial and anticancer activities of Beta vulgaris L. root (2018) Fresenius Environmental Bulletin, 27 (9), pp. 6369-6378; Erkan, N., Antioxidant activity and phenolic compounds of fractions from Portulaca oleracea L (2012) Food Chemistry, 133 (3), pp. 775-781; Gil, M.I., Tom�s-Barber�n, F.A., Hess-Pierce, B., Kader, A.A., Antioxidant capacities, phenolic compounds, carotenoids, and vitamin C contents of nectarine, peach, and plum cultivars from California (2002) Journal of Agricultural and Food Chemistry, 50 (17), pp. 4976-4982; Goupy, P., Hugues, M., Biovin, P., Amiot, M.J., Antioxidant composition and activity of barley (Hordeum vulgare) and malt extracts and of isolated phenolic compounds (1999) Journal of the Science of Food and Agriculture, 79 (12), pp. 1625-1634; Harbone, J.B., (1998) A guide to modern techniques of plant analysis, pp. 54-84. , Second Ed, Chapman and Hall, London; Islam, N.U., Amin, R., Shahid, M., Amin, M., Zaib, S., Iqbal, J., A multitarget therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, ureaseinhibition, anti-inflammatory and analgesic properties (2017) BMC Complementary and Alternative Medicine, 17 (1), p. 276; Jeyanthi, R.L., Sharmila, S., Das, M.P., Seshiah, C., Extraction and purification of carotenoids from vegetables (2014) Journal of Chemical and Pharmaceutical Research, 6 (4), pp. 594-598; Karabegovic, I.T., Stojicevic, S.S., Velickovic, D.T., Nikolic, N.C., Lazic, M.L., Optimization of microwave-assisted extraction of cherry laurel fruit (2014) Separation Science and Technology, 49 (3), pp. 416-423; Kayano, S., Kikuzaki, H., Fukutsuka, N., Mitani, T., Nakatani, N., Antioxidant activity of prune (Prunus domestica L.) constituents and a new synergist (2002) Journal of Agricultural and Food Chemistry, 50 (13), pp. 3708-3712; Kesba, H.H., El-Beltagi, H.S., Biochemical changes in grape rootstocks resulted from humic acid treatments in relation to nematode infection (2012) Asian Pacific Journal of Tropical Biomedicine, 2 (4), pp. 287-293; Kikuzaki, H., Kayano, S.I., Fukutsuka, N., Aoki, A., Kasamatsu, K., Yamasaki, Y., Mitani, T., Nakatani, N., Abscisic acid related compounds and lignans in prunes (Prunus domestica L.) and their oxygen radical absorbance capacity (ORAC) (2004) Journal of Agricultural and Food Chemistry, 52 (2), pp. 344-349; Kim, D.O., Jeong, S.W., Lee, C.Y., Antioxidant capacity of phenolic phytochemicals from various cultivars of plums (2003) Food Chemistry, 81 (3), pp. 321-326; Kobeasy, M.I., El-Beltagi, H.S., El-Shazly, M.A., Khattab, E.A., Induction of resistance in Arachis hypogaea L. against Peanut mottle virus by nitric oxide and salicylic acid (2011) Physiological and Molecular Plant Pathology, 76 (2), pp. 112-118; Lee, J., Durst, R.W., Wrolstad, R.E., Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method: collaborative study (2005) Journal of AOAC International, 88 (5), pp. 1269-1278; Li, Y., Brown, R.W., Bonner, M.R., Deng, F., Tian, L., Mu, L., (2014) Positive relationship between total antioxidant status and chemo-kines observed in adults, , Oxidative Medicine and Cellular Longevity; Lombardi-Boccia, G., Lucarini, M., Lanzi, S., Aguzzi, A., Cappelloni, M., Nutrients and antioxidant molecules in yellow plums (Prunus domestica L.) from conventional and organic productions: A comparative study (2004) Journal of Agricultural and Food Chemistry, 52 (1), pp. 90-94; Mattila, P., Astola, J., Kumpulainen, J., Determination of flavonoids in plant material by HPLC with diode-array and electro-array detections (2000) Journal of Agricultural and Food Chemistry, 48 (12), pp. 5834-5841; Mehta, S., Soni, N., Satpathy, G., Gupta, R.K., Evaluation of nutritional, phytochemical, antioxidant and antibacterial activity of dried plum (Prunus domestica) (2014) Journal of Pharmacognosy and Phytochemistry, 3 (2), pp. 166-171; Orhan, E.I., Akkol, K.E., Estimation of neuroprotective effects of Laurocerasus officinalis Roem (cherry laurel) by in vitro methods (2011) Food Research International, 44 (3), pp. 818-822; Park, H.R., Park, E., Rim, A.R., Jeon, K.I., Huang, J.H., Lee, S.C., Antioxidant activity of extracts from Acanthopanax senticosus (2006) African Journal of Biotechnology, 5 (23), pp. 2388-2396; Phongpaichit, S., Nikom, J., Rungjindamai, N., Sakayaroj, J., Hutadilok-Towatana, N., Rukachaisirikul, V., Kirtikara, K., Biological activities of extracts from endophytic fungi isolated from Garcinia plants (2007) FEMS Immunology and Medical Microbiology, 51 (3), pp. 517-525; Poongodi, T., Srikanth, R., Lalitha, G., Phytochemistry, GC-MS analysis and in vitro cytotoxic activity of Prunus angustifolia leaves against MCF-7 breast cancer cell line (2015) World Journal of Pharmacy and Pharmaceutical Sciences, 4, pp. 1489-1499; Prior, R.L., Fruits and vegetables in the prevention of cellular oxidative damage (2003) The American Journal of Clinical Nutrition, 78 (3), pp. 570-578; Repetto, G., del Peso, A., Zurita, J.L., Neutral red uptake assay for the estimation of cell viability/cytotoxicity (2008) Nature Protocols, 3 (7), pp. 1125-1131; Sandra, V., Ante, G., Zoran, S., Nadica, D., Stjepan, P., Jasmina, D., Chemical composition and antioxidant capacity of three plum cultivars (2009) Agriculturae Conspectus Scientificus, 74 (3), pp. 273-276; Saxena, V., Mishra, G., Saxena, A., Vish-wakarma, K.R., A comparative study on quantitative estimation of tannins in Terminalia chebula, Terminalia belerica, Terminalia arjuna and Saraca indica using spectrophotometer (2013) Asian Journal of Pharmaceutical and Clinical Research, 6 (3), pp. 148-149; Shallan, M.A., El-Beltagi, H.S., Mona, A.M., Amera, T.M., Sohir, N.A., Effect of amylose content and pre-germinated brown rice on serum blood glucose and lipids in experimental animal (2010) Australian Journal of Basic and Applied Sciences, 4 (2), pp. 114-121; Singleton, V., Rossi, J., Colorimetry of total phenolics with phosphomolibdic-phosphotungstic acid reagents (1965) The American Journal of Enology and Viticulture, 16 (3), pp. 144-158; S�jka, M., Kolodziejczyk, K., Milala, J., Abadias, M., Vi�as, I., Guyot, S., Baron, A., Composition and properties of the polyphenolic extracts obtained from industrial plum pomaces (2015) Journal of Functional Foods, 12, pp. 168-178; Sumathy, N., Sumathy, J., Antibacterial and antifungal activity of musa fruit peels against skin and gastrointestinal tract diseases (2011) Herbal Tech Industry, 2, pp. 9-11; Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T.D., Mazur, M., Telser, J., Free radicals and antioxidants in normal physiological functions and human disease (2007) The International Journal of Biochemistry and Cell Biology, 39 (1), pp. 44-84; Vinson, J.A., Su, X., Zubik, L., Bose, P., Phenol antioxidant quantity and quality in foods: fruits (2001) Journal of Agricultural and Food Chemistry, 49 (11), pp. 5315-5321; Vlaic, R., Socaci, S., Muresan, A.E., Muresan, C., Moldovan, O.P., Muste, S., Muresan, V., Bioactive compounds and volatile profile dynamics during fruit growth of several plums cultivars (2017) Journal of Agricultural Science and Technology, 19, pp. 1565-1576; Yang, J., Martinson, T.E., Liu, R.H., Phytochemical profiles and antioxidant activities of wine grapes (2009) Food Chemistry, 116 (1), pp. 332-339; Yaqeen, Z., Naqvi, N-u-H., Sohail, T., Fatima, N., Imran, H., Screening of solvent dependent antibacterial activity of Prunus domestica (2013) Pakistan Journal of Pharmaceutical Sciences, 26 (2), pp. 409-414; Zhishen, J., Mengcheng, T., Jianming, W., The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals (1999) Food Chemistry, 64 (4), pp. 555-559 | |
| dcterms.source | Scopus |