The protective effect of Korean red ginseng against rotenone-induced parkinsons disease in rat model: Modulation of nuclear factor- and caspase-3

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorZaafan M.A.
dc.contributor.authorAbdelhamid A.M.
dc.contributor.authorIbrahim S.M.
dc.contributor.otherPharmacology & Toxicology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:41Z
dc.date.available2020-01-09T20:40:41Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractObjective: Korean red ginseng was reported to have many biological effects like the antioxidant and the anti-inflammatory activities. Oxidative stress and neuro-inflammation play major roles in the pathogenesis of Parkinsons disease (PD). The current study aimed to investigate the protective effects of ginseng on rotenone-induced PD in rats. Methods: Rats were randomly allocated into 4 groups: Normal rats, rotenone control, ginseng+rotenone and ginseng only treated rats. The severity of PD was evaluated through locomotor activity perceived in the open field test, histological examination and immunohistochemical detection of amyloid-? in brain tissues, in addition to the biochemical assessment of tyrosine hydroxylase activity in brain tissues. Moreover, the following parameters were investigated for studying the possible mechanisms of ginseng neuroprotective effect: Nuclear factor-?? (NF-??), tumor necrosis factor-alpha (TNF-?), caspase- 3, lipid peroxides and reduced glutathione (GSH). Results: Ginseng exhibited potent neuroprotective effect that was reflected upon the histopathological examination, marked improvement in the locomotor activity and through its ability to suppress the amyloid-? deposition in the cortex and striatum along with significant increase in the tyrosine hydroxylase activity. Ginseng successfully inhibited the NF-?? inflammatory pathway in brain tissues beside the inhibition of other oxidative stress and inflammatory mediators. Furthermore, it exhibited antiapoptotic effect via the inhibition of caspase-3 expression. Conclusion: Ginseng could be a promising treatment in PD. It can suppress dopaminergic neuron degeneration through variable mechanisms mainly via inhibition of NF-?? pathway in addition to inhibition of oxidative stress and apoptosis. 2019 Bentham Science Publishers.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=15581&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.2174/1389201020666190611122747
dc.identifier.doiPubMed ID 31198107
dc.identifier.issn13892010
dc.identifier.otherhttps://doi.org/10.2174/1389201020666190611122747
dc.identifier.otherPubMed ID 31198107
dc.identifier.urihttps://t.ly/AZxY8
dc.language.isoEnglishen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofseriesCurrent Pharmaceutical Biotechnology
dc.relation.ispartofseries20
dc.subjectAnti-oxidanten_US
dc.subjectCaspase-3en_US
dc.subjectGinsengen_US
dc.subjectNuclear factor-??en_US
dc.subjectParkinsons diseaseen_US
dc.subjectRat modelen_US
dc.subjectamyloid beta proteinen_US
dc.subjectantiinflammatory agenten_US
dc.subjectantioxidanten_US
dc.subjectcaspase 3en_US
dc.subjectglutathione peroxidaseen_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectkorean red ginsengen_US
dc.subjectlipid peroxidaseen_US
dc.subjectmalonaldehydeen_US
dc.subjectplant extracten_US
dc.subjecttumor necrosis factoren_US
dc.subjecttyrosine 3 monooxygenaseen_US
dc.subjectunclassified drugen_US
dc.subjectCasp3 protein, raten_US
dc.subjectcaspase 3en_US
dc.subjectdopamineen_US
dc.subjectglutathioneen_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectneuroprotective agenten_US
dc.subjectplant extracten_US
dc.subjectrotenoneen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantiinflammatory activityen_US
dc.subjectArticleen_US
dc.subjectbrain diseaseen_US
dc.subjectbrain hemorrhageen_US
dc.subjectbrain tissueen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug mechanismen_US
dc.subjectenzyme activityen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectexperimental parkinsonismen_US
dc.subjectginsengen_US
dc.subjectgliosisen_US
dc.subjecthistologyen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectimmunomodulationen_US
dc.subjectlocomotionen_US
dc.subjectmaleen_US
dc.subjectmicroscopyen_US
dc.subjectnerve cell degenerationen_US
dc.subjectneuroprotectionen_US
dc.subjectnonhumanen_US
dc.subjectopen field behavioren_US
dc.subjectopen field testen_US
dc.subjectoxidative stressen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectprotein analysisen_US
dc.subjectprotein expressionen_US
dc.subjectpyknosisen_US
dc.subjectraten_US
dc.subjectvenous congestionen_US
dc.subjectanimalen_US
dc.subjectanimal behavioren_US
dc.subjectapoptosisen_US
dc.subjectchemistryen_US
dc.subjectdrug effecten_US
dc.subjectisolation and purificationen_US
dc.subjectmetabolismen_US
dc.subjectPanaxen_US
dc.subjectparkinsonismen_US
dc.subjectpathologyen_US
dc.subjectrandomizationen_US
dc.subjectSouth Koreaen_US
dc.subjectWistar raten_US
dc.subjectAnimalsen_US
dc.subjectApoptosisen_US
dc.subjectBehavior, Animalen_US
dc.subjectCaspase 3en_US
dc.subjectDopamineen_US
dc.subjectGlutathioneen_US
dc.subjectMaleen_US
dc.subjectNeuroprotective Agentsen_US
dc.subjectNF-kappa Ben_US
dc.subjectOxidative Stressen_US
dc.subjectPanaxen_US
dc.subjectParkinsonian Disordersen_US
dc.subjectPlant Extractsen_US
dc.subjectRandom Allocationen_US
dc.subjectRats, Wistaren_US
dc.subjectRepublic of Koreaen_US
dc.subjectRotenoneen_US
dc.titleThe protective effect of Korean red ginseng against rotenone-induced parkinsons disease in rat model: Modulation of nuclear factor- and caspase-3en_US
dc.typeArticleen_US
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