Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAhmed, Lamiaa A. ,
dc.contributor.authorHassan, Omnia F. ,
dc.contributor.authorGalal, Omneya
dc.contributor.authorMansour, Dina F. ,
dc.contributor.authorEl-Khatib, Aiman
dc.date.accessioned2020-05-15T13:10:21Z
dc.date.available2020-05-15T13:10:21Z
dc.date.issued2020-05
dc.descriptionScopusen_US
dc.description.abstractBackground Acute myocardial infarction (AMI) remains the most common cause of morbidity and mortality worldwide. The present study was directed to investigate the beneficial effects of benfotiamine pre- and post-treatments in isoproterenol (ISO)-induced MI in rats. Methods Myocardial heart damage was induced by subcutaneous injection of ISO (150 mg/kg) once daily for two consecutive days. Benfotiamine (100 mg/kg/day) was given orally for two weeks before or after ISO treatment. Results ISO administration revealed significant changes in electrocardiographic recordings, elevation of levels of cardiac enzymes; creatinine kinase (CK-MB) and troponin-I (cTn-I), and perturbation of markers of oxidative stress; nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and markers of inflammation; protein kinase C (PKC), nuclear factor-kappa B (NF-κB) and metalloproteinase-9 (MMP-9). The apoptotic markers (caspase-8 and p53) were also significantly elevated in ISO groups in addition to histological alterations. Groups treated with benfotiamine pre- and post-ISO administration showed significantly decreased cardiac enzymes levels and improved oxidative stress, inflammatory and apoptotic markers compared to the ISO groups. Conclusion The current study highlights the potential role of benfotiamine as a promising agent for prophylactic and therapeutic interventions in myocardial damage in several cardiovascular disorders via NADPH oxidase inhibition.en_US
dc.description.sponsorshipHelwan Universityen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=10600153309&tip=sid&clean=0
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dc.identifier.doihttps://doi.org/10.1371/journal.pone.0232413
dc.identifier.issn19326203
dc.identifier.otherhttps://doi.org/10.1371/journal.pone.0232413
dc.identifier.urihttps://t.ly/UQkE
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofseriesPLoS ONE;Volume 15, Issue 5, May 2020, Article number e0232413
dc.subjectbenfotiamineen_US
dc.subjectNADPH oxidase inhibitoren_US
dc.titleBeneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in ratsen_US
dc.typeArticleen_US

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