Folate-chitosan nanoparticles triggered insulin cellular uptake and improved in vivo hypoglycemic activity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl Leithy E.S.
dc.contributor.authorAbdel-Bar H.M.
dc.contributor.authorAli R.A.-M.
dc.contributor.otherDepartment of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pharmaceutics
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherUniversity of Sadat City
dc.contributor.otherMenoufia
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:31Z
dc.date.available2020-01-09T20:40:31Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThe aim of this study was to prove a prolonged control of glucose levels, in rats, by the oral use of insulin folate-chitosan nanoparticles (FA-CS NPs). It was possible to prepare positively charged NPs with an average particle size of 288 � 5.11 nm and >80% entrapment efficiency. The system was able to enhance the stability of insulin in presence of GIT enzymes, with less than 10% release at pH 1.2 and an 8 hr released amount of 38.92 � 4.52% in PBS pH 7.4. A 5 fold enhancement in insulin intestinal permeability and cellular uptake over insulin solution was proven. The cellular uptake pathways was found to occur by several mechanisms. Besides, cell compatibility and absence of histopathological alterations was also demonstrated. Finally, a controlled blood glucose level for 8 h in rats. These results anticipated FA-CS NPs as a promising oral insulin candidate. � 2019 Elsevier B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=22454&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2019.118708
dc.identifier.doiPubMed ID 31593805
dc.identifier.issn3785173
dc.identifier.otherhttps://doi.org/10.1016/j.ijpharm.2019.118708
dc.identifier.otherPubMed ID 31593805
dc.identifier.urihttps://t.ly/YZR0Y
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesInternational Journal of Pharmaceutics
dc.relation.ispartofseries571
dc.subjectCellular uptakeen_US
dc.subjectChitosanen_US
dc.subjectControlled blood glucoseen_US
dc.subjectFolic aciden_US
dc.subjectInsulinen_US
dc.subjectOral deliveryen_US
dc.subjectantidiabetic agenten_US
dc.subjectchitosan nanoparticleen_US
dc.subjectfolate chitosan nanoparticleen_US
dc.subjectfolic aciden_US
dc.subjectglucoseen_US
dc.subjectinsulinen_US
dc.subjectunclassified drugen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectantidiabetic activityen_US
dc.subjectArticleen_US
dc.subjectCaco-2 cell lineen_US
dc.subjectcell viabilityen_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectenzymatic degradationen_US
dc.subjectglucose blood levelen_US
dc.subjecthistopathologyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectin vivo studyen_US
dc.subjectinsulin blood levelen_US
dc.subjectinsulin releaseen_US
dc.subjectinternalizationen_US
dc.subjectintestine mucosa permeabilityen_US
dc.subjectmaleen_US
dc.subjectmean residence timeen_US
dc.subjectnonhumanen_US
dc.subjectparticle sizeen_US
dc.subjectpHen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectzeta potentialen_US
dc.titleFolate-chitosan nanoparticles triggered insulin cellular uptake and improved in vivo hypoglycemic activityen_US
dc.typeArticleen_US
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