Role of chronic E. Coli infection in the process of bladder cancer- An experimental study

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Mosalamy H.
dc.contributor.authorSalman T.M.
dc.contributor.authorAshmawey A.M.
dc.contributor.authorOsama N.
dc.contributor.otherBiochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAl-Azhar University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Cancer Biology Department
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern Sciences and Arts University
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:27Z
dc.date.available2020-01-25T19:58:27Z
dc.date.issued2012
dc.descriptionScopus
dc.description.abstractBackground: Bladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as a risk factor for bladder cancer. Escherichia coli (E. coli) infection is responsible for 70% of urinary tract infection. This study aimed to evaluate the role of chronic E. coli infection during bladder carcinogenesis. In order to achieve this aim, we investigated the histopathological changes in bladder tissue and measured the level of nuclear factor kappa p65 (NF-Bp65), Bcl-2 and interleukin 6 (IL-6) in four groups each consisting of 25 male albino rats except of control group consisting of 20 rats. The first group was normal control group, the second group was infected with E. coli, the third group was administered nitrosamine precursor, and the forth group was infected with E. coli and administered nitrosamine precursor. Results: The histopathological examination revealed that E. coli infected group was able alone to produce some histopathological changes in bladder tissue and that nitrosamine precursor plus E. coli group showed highest incidences of urinary bladder lesions than the nitrosamine precursor group. NF-Bp65, Bcl-2 and IL-6 levels were significantly higher in nitrosamine precursor plus E. coli group than the other groups. Conclusion: These findings suggested that urinary bladder infection by E. coli may play a major additive and synergistic role during bladder carcinogenesis. � 2012 El-Mosalamy et al.; licensee BioMed Central.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=5700191215&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1186/1750-9378-7-19
dc.identifier.doiPubMed ID :
dc.identifier.issn17509378
dc.identifier.otherhttps://doi.org/10.1186/1750-9378-7-19
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/BX3KL
dc.language.isoEnglishen_US
dc.relation.ispartofseriesInfectious Agents and Cancer
dc.relation.ispartofseries7
dc.subjectBcl-2en_US
dc.subjectBladder carcinogenesisen_US
dc.subjectE. colien_US
dc.subjectIL-6en_US
dc.subjectNF-Bp65en_US
dc.subjectinterleukin 6en_US
dc.subjectnitrosamineen_US
dc.subjectprotein bcl 2en_US
dc.subjecttranscription factor RelAen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectbladder canceren_US
dc.subjectcontrolled studyen_US
dc.subjectEscherichia coli infectionen_US
dc.subjectexperimental studyen_US
dc.subjecthistopathologyen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectpathophysiologyen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjecturinary tract infectionen_US
dc.titleRole of chronic E. Coli infection in the process of bladder cancer- An experimental studyen_US
dc.typeArticleen_US
dcterms.isReferencedByBeaglehole, R., Irwin, A., Prentice, T., Changing history (2004) The World Health Report, 157, p. 122; El Mawla, N.G., El Bolkainy, M.N., Khaled, H.M., Bladder cancer in Africa: Update (2001) Seminars in Oncology, 28 (2), pp. 174-178; Abd El Gawad, I.A., Moussa, H.S., Nasr, M.I., El Gemae, E.H., Masooud, A.M., Ibrahim, I.K., El Hifnawy, N.M., Comparative Study of NMP-22 Telomerase and BTA in the detection of bladder cancer (2005) J Egypt Natl Canc Inst, 17 (3), pp. 193-202. , 16799657; Jankovi, S., Radosavljevi, V., Risk factors of bladder cancer (2007) Tumori, 93, pp. 4-12. , 17679479; Pasin, E., Josephson, D.Y., Mitra, A.P., Cote, R.J., Stein, G.P., Superficial bladder cancer: An update on etiology molecular development classification and natural history (2008) Rev Urol, 10 (1), pp. 31-43. , 18470273; Lax, A.J., Thomas, W., How bacteria could cause cancer: One step at a time (2002) Trends in Microbiology, 10 (6), pp. 293-299. , DOI 10.1016/S0966-842X(02)02360-0, PII S0966842X02023600; Karin, M., Greten, F.R., NF-?B: Linking inflammation and immunity to cancer development and progression (2005) Nature Reviews Immunology, 5 (10), pp. 749-759. , DOI 10.1038/nri1703; Shishodia, S., Chaturvedi, M.M., Aggarwal, B.B., Role of curcumin in cancer therapy (2007) Current Problems in Cancer, 31 (4), pp. 243-305. , DOI 10.1016/j.currproblcancer.2007.04.001, PII S0147027207000219, Role of Curcumin in Cancer Therapy; Pacifico, F., Leonardi, A., NF-?B in solid tumors (2006) Biochemical Pharmacology, 72 (9 SPEC. ISS.), pp. 1142-1152. , DOI 10.1016/j.bcp.2006.07.032, PII S0006295206004862; Rose-John, S., Schooltink, H., Cytokines are a therapeutic target for the prevention of inflammation-induced cancers (2007) Recent Results Cancer Res, 174, pp. 57-66. , 10.1007/978-3-540-37696-5-5 17302185; Andrews, B., Shariat, S.F., Kim, J.-H., Wheeler, T.M., Slawin, K.M., Lerner, S.P., Preoperative plasma levels of interleukin-6 and its soluble receptor predict disease recurrence and survival of patients with bladder cancer (2002) Journal of Urology, 167 (3), pp. 1475-1481; Schetter, A.J., Heegaard, N.H., Harris, C.C., Inflammation and cancer: Interweaving microRNA free radical cytokine and p53 pathways (2010) Carcinogenesis, 31, pp. 37-49. , 10.1093/carcin/bgp272 19955394; Ashmawey, A.M., Mohamed, W.S., Abdel-Salam, I.M., El-Gendy, S.M., Ali, A.I., El-Aaser, A.A., Role of urinary tract bacterial infection in the process of bladder carcinogenesis (molecular and biochemical studies) (2011) AJMS, 2, pp. 31-40; Kawai, T., Akira, S., Signaling to NF-?B by Toll-like receptors (2007) Trends in Molecular Medicine, 13 (11), pp. 460-469. , DOI 10.1016/j.molmed.2007.09.002, PII S1471491407001840; Feng, D., Ling, W., Duan, R., Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK p38MAPK and NF-B in macrophages (2010) Inflamm Res, 59, pp. 115-121. , 10.1007/s00011-009-0077-8 19693648; Hsieh, N., Chang, A.S., Teng, C., Chen, C., Yang, C., Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways (2011) J Biomed Sci, 18, p. 28. , 10.1186/1423-0127-18-28 21548916; Saban, M.R., Hellmich, H., Nguyen, N.-B., Winston, J., Hammond, T.G., Saban, R., Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation (2001) Physiological Genomics, 2001 (5), pp. 147-160; Schilling, J.D., Martin, S.M., Hunstad, D.A., Patel, K.P., Mulvey, M.A., Justice, S.S., Lorenz, R.G., Hultgren, S.J., CD14- and toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli (2003) Infection and Immunity, 71 (3), pp. 1470-1480. , DOI 10.1128/IAI.71.3.1470-1480.2003; Faherty, C.S., Maurelli, A.T., Staying alive: Bacterial inhibition of apoptosis during infection (2008) Trends Microbiol, 16, pp. 173-180. , 10.1016/j.tim.2008.02.001 18353648; Palsson-Mcdermott, E.W., Oneill, L.A.J., Signal transduction by the lipopolysaccharide receptor Toll-like receptor-4 (2004) Immunology, 133 (2), pp. 153-162; El Gendy, S., Hessien, M., Abdel Salam, I., Morad, M., El-Magraby, K., Ibrahim, H.A., Kalifa, M.H., El-Aaser, A.A., Evaluation of the possible antioxidant effects of Soybean and Nigella Sativa during experimental hepatocarcinogenesis by nitrosamine Precursors (2007) Turk J Biochem, 32 (1), pp. 5-11; Neuhaus, J., Schlichting, N., Oberbach, A., Stolzenburg, J.-U., Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells (2007) Urologe - Ausgabe A, 46 (9), pp. 1193-1197. , DOI 10.1007/s00120-007-1479-2; Higgy, N.A., Verma, A.K., Erturk, E., Bryan, G.T., Augmentation of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) bladder carcinogenesis in Fischer 344 female rats by urinary tract infection (1885) Proc Amer Assoc Cancer Res, 26, pp. 118-124; Tripathi, D.N., Jena, G.B., Effect of melatonin on the expression of Nrf2 and NF-B during cyclophosphamide-induced urinary bladder injury in rat (2010) J Pineal Res, 48, pp. 324-331. , 10.1111/j.1600-079X.2010.00756.x 20433640
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