Cathepsin D expression in chronic plaque psoriasis: An immunohistochemical study

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAbdou A.G.
dc.contributor.authorMaraee A.H.
dc.contributor.authorShoeib M.A.E.
dc.contributor.authorElsammie A.A.A.
dc.contributor.authorElnaidany N.F.
dc.contributor.otherPathology Department
dc.contributor.otherMenofiya University
dc.contributor.otherShebein Elkom
dc.contributor.otherEgypt; Dermatology and Andrology Department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenofiya University
dc.contributor.otherShebein Elkom
dc.contributor.otherEgypt; Clinical Pharmacy Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherOctober City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:29Z
dc.date.available2020-01-25T19:58:29Z
dc.date.issued2011
dc.descriptionScopus
dc.description.abstractCathepsins are lysosomal cysteine proteases, which are involved in a variety of physiologic processes such as proenzyme activation, antigen presentation, tissue remodeling, bone matrix resorption, and pathologic processes such as facilitating tumor invasion and modulating the process of programmed cell death. This study aimed to evaluate the pattern of cathepsin D (CD) expression in chronic plaque psoriasis in comparison to normal skin by means of immunohistochemistry. The study included 34 patients presenting with chronic plaque psoriasis and 10 ageand sex-matched normal subjects as control group. Sixty percent of normal skin showed granular positivity for CD confined to basal layer. CD is upregulated in psoaritic lesion with 94.1% positivity making a significant difference between psoriasis and normal skin as regards the percentage and distribution of CD expression, where the latter was predominantly diffuse in psoriatic lesion. The eight cases exposed to PUVA therapy showed reduction of CD positivity to 62.5% with a predominance of mild staining and focal expression compared to pretreatment biopsies. CD may have a role in the pathogenesis of psoriasis in view of its high percentage and diffuse expression in psoriatic epidermis. CD degradative capacity may be responsible for disordered differentiation and scale formation characteristic of psoriasis. Reduction of CD expression may be one of the pathways of PUVA mechanism of action.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24217&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn1330027X
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/2ddPR
dc.language.isoEnglishen_US
dc.relation.ispartofseriesActa Dermatovenerologica Croatica
dc.relation.ispartofseries19
dc.subjectCathepsin Den_US
dc.subjectImmunohistochemistryen_US
dc.subjectProteasesen_US
dc.subjectPsoriasisen_US
dc.subjectcathepsin Den_US
dc.subjectmethoxsalenen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectarticleen_US
dc.subjectchilden_US
dc.subjectchronic diseaseen_US
dc.subjectchronic psoriasis vulgarisen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmaleen_US
dc.subjectprotein expressionen_US
dc.subjectpsoriasis vulgarisen_US
dc.subjectPUVAen_US
dc.subjectschool childen_US
dc.subjectskin biopsyen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectCathepsin Den_US
dc.subjectChilden_US
dc.subjectChronic Diseaseen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPsoriasisen_US
dc.subjectPUVA Therapyen_US
dc.subjectSkinen_US
dc.subjectYoung Adulten_US
dc.titleCathepsin D expression in chronic plaque psoriasis: An immunohistochemical studyen_US
dc.typeArticleen_US
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