Faculty Of Pharmacy Research Paper

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    Synthesis of novel tryptophan derivatives of potential biological activity
    (2009) Mohareb R.M.; Louca N.A.; Elmegeed G.A.; Hana H.Y.; Departament of Organic Chemistry; Faculty of Pharmacy; October University for Modem Sciences and Arts (MSA); El-Wahaat Road; October City; Egypt; Chemistry Department; Faculty of Science; Cairo University; Giza; Egypt; Hormone Department; National Research Centre; Dokki; Giza; Egypt
    Tryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetonitrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding ?-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl ester derivatives 8a,b and thiophenotryptophan methyl ester derivatives 10a,b, respectively. Also compound 3 reacts with benzaldehyde to give the condensated product 12. The reactivity of the latter product towards chemical reagents was studied to form pyridine, pyrazole and isoxazole derivatives.