Browsing by Author "Mohamed H.I."

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Chemical Composition and Biological Activity of Physalis peruviana L. [Chemische Zusammensetzung und biologische Aktivitt von Physalis peruvianaL.
(Springer Verlag, 2019) El-Beltagi H.S.; Mohamed H.I.; Safwat G.; Gamal M.; Megahed B.M.H.; Faculty of Agriculture; Biochemistry Department; Cairo University; Giza; Cairo; Egypt; College of Agriculture and Food Sciences; Agricultural Biotechnology Department; King Faisal University; Alhassa; Saudi Arabia; Research Park (CURP); Cairo University; Giza; Cairo; Egypt; Faculty of Education; Department of Biological and Geological science; Ain shams University; Cairo; Egypt; Faculty of Biotechnology; October University for Modern Science and Art (MSA); Giza; Egypt
Physalis peruviana L. belongs to the family Solanaceae and is considered as plant used for treating various diseases. The protective mechanism of Physalis consists of the ability to scavenge reactive oxygen species (ROS) and to enhance the antioxidant system in the human body. The ethanolic extract of Physalis peruviana fruits contains valuable and active compounds such as carotenoids, phenols, flavonoids, tannin, alkaloids, vitamins C, B3 and B6. Therefore, Physalis peruviana extract has antioxidant and antimicrobial activity against gram-positive and gram-negative bacteria. Gram-positive Bacillus cereus demonstrated higher susceptibility than gram-negative Escherichia coli and Pseudomonas typhimureum. Also, the extract showed positive effect on the fungus used (Aspergillus niger and Candida albicans). In addition, high concentrations of Physalis peruviana ethanolic extract (800 g/ml) exhibited significant anticancer activity against lung (A549) cells but slight effect against colorectal adenocarcinoma (Caco-2) cells. 2019, Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature.
Evaluation of some chemical constituents, antioxidant, antibacterial and anticancer activities of beta Vulgaris L. Root
(Parlar Scientific Publications, 2018) El-Beltagi H.S.; Mohamed H.I.; Megahed B.M.H.; Gamal M.; Safwat G.; Faculty of Agriculture; Biochemistry Department; Cairo University; Giza; Cairo; Egypt; Cairo University; Research Park (CURP); Giza; Cairo; Egypt; Faculty of Education; Department of Biological and Geological Science; Ain Shams University; Cairo; Egypt; Faculty of Biotechnology; October University for Modern Science and Art (MSA); Egypt
Beta vulgaris is belonging to the family Chenopodiaceae and has several varieties with bulb colors ranging from yellow to red. Deep redcolored beet roots are the most popular for human consumption, both cooked and raw as salad or juice. The ethanolic extract of beetroots contains valuable and active compounds such as carotenoids, phenols, flavonoids, tannin, alkaloids, vitamins C, B3, B6 and B9. Therefore, beetroot extract has antioxidant and antimicrobial activity against gram positive and negative bacteria. Gram-positive bacteria Staphylococcus aureus and Bacillus cereus demonstrated higher susceptibility than Gramnegative Escherichia coli and Pseudomonas typhimureum. Beta vulgaris ethanolic extract exhibit significant anticancer activity against lung (A549) but slight effect against colorectal adenocarcinoma Caco-2 cell lines at the high concentrations of ethanolic extract (800 ?g/ml). � 2018 Malaysian Nature Society. All rights reserved.
GC-MS analysis, antioxidant, antimicrobial and anticancer activities of extracts from Ficus sycomorus fruits and leaves
(Academic Press, 2019) El-Beltagi H.S.; Mohamed H.I.; Abdelazeem A.S.; Youssef R.; Safwat G.; Cairo University; Faculty of Agriculture; Biochemistry Department; Giza; Cairo; Egypt; Cairo University; Research Park (CURP); Giza; Cairo; Egypt; Ain Shams University; Faculty of Education; Department of Biological and Geological Science; Cairo; Egypt; October University for Modern Science and Art (MSA); Faculty of Biotechnology; Egypt
Higher plants have been utilized worldwide as characteristic drug a long time to cure human diseases. About 80% of individuals globally use plants as safe sources of medication to cure human diseases through completely different medicine system. One of the available indigenous medicinal plants, Ficus sycomorus belongs to the Moraceae family. The plant contains totally different teams of biologically active compounds that square measure chargeable for the biological activity. Ethanolic and ethyl acetate extracts of leaves of Ficus sycomorus contain higher concentrations of total phenols, flavonoids, tannins, alkaloids and steroids than the fruit extracts. Ethanolic extract in both fruits and leaves gave higher concentrations of phytochemical compounds than the ethyl acetate extracts. Therefore, fruit and leaves extract have antioxidant and antimicrobial activity against gram positive, negative bacteria and fungus. Also, the percentage of Liver cell line (HepG2), Colorectal adenocarcinoma (Caco-2) and Breast cell line (MCF-7) viability was decreased with increasing the concentrations of the ethanolic extract of fruits and leaves of Ficus sycomorus. The high concentrations of ethanolic extract of fruits caused high reduction in the viability of cancer cells, especially in Colorectal adenocarcinoma (Caco-2) cell line. In addition, phytochemical compound screened by GC-MS method. In GC-MS analysis, 12 bioactive phytochemical compounds were identified in fruits and 29 bioactive compounds were detected in leaves extract. These totally different active phytochemicals are found to possess a good vary of activities, which can facilitate within the protection against incurable diseases. � 2019, Academic Press.
Phytochemical and biological activities of two asteraceae plants senecio vulgaris and pluchea dioscoridis L.
(SILAE (Italo-Latin American Society of Ethnomedicine), 2019) Hamed M.M.; Abd El-Mobdy M.A.; Kamel M.T.; Mohamed H.I.; Bayoumi A.E.; Medicinal Chemistry Department; Theodor Bilharz Research Institute; Giza; Egypt; Faculty of Biotechnology; October University for Modern Sciences and Arts (MSA); Egypt; Biological and Geological Sciences Department; Faculty of Education; Ain Shams University; Egypt
Identifying ornamental plants as new natural anticancer sources is always of great effective for the ornamental and horticultural industries. The investigator for Senecio vulgaris were identified by GC-MS to give a total of 14 sesquiterpenoids, represents 98.53% of the total oil, while Pluchea dioscoridis L. shows the standardization of 30 compounds essential oil represents 91.28% of the total oil. Senecio vulgaris essential oil showed a high brine shrimp lethality with LC50 value of 8 ?g/ml followed by Pluchea dioscoridis L with LC50 value of 24 ?g/ml. Following cytotoxic activity was screened by MTT viability test against HePG2 cell line. Inhibitory activity against Hepatocellular carcinoma cells of S. vulgaris and P. dioscoridis L essential oil extract under the experimental conditions exhibited a promising IC50 of 5.63 and 11.50 �g/ml, respectively compared to Doxorubicin as a control. The results demonstrated the potential of the two plants essential oils for cancer treatments; therefore, in the future in vivo experiments are required for further understanding of the effect of these plants on cancer cells to be useful in medicine. � 2019, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.
Phytochemical screening, antimicrobial, antiaxidant, anticancer activities and nutritional values of cactus (opuntia ficus indicia) pulp and peel
(Parlar Scientific Publications, 2019) El-Beltagi H.S.; Mohamed H.I.; Elmelegy A.A.; Eldesoky S.E.; Safwat G.; Biochemistry Department; Faculty of Agriculture; Cairo University; Giza; Cairo; Egypt; Agriculture Biotechnology Department; College of Agriculture and Food Sciences; King Faisal University; P.O. Box 420; Alhassa; 31982; Saudi Arabia; Cairo University Research Park (CURP); Giza; Cairo; Egypt; Department of Biological and Geological Science; Faculty of Education; Ain Shams University; Cairo; Egypt; Faculty of Biotechnology; October University for Modern Science and Art (MSA); Egypt
Opuntia ficus-indica (L.) Mill is belonging to the family Cactaceae. The chemical composition of the pulp and peel of cactus showed that pulp has high content of proteins, moisture and lipid but low con-tent of total fiber and ash as compared to the peel. The peels of the cactus were considerably higher in fiber than the pulp. The ethanolic and ethyl acetate extracts of peel have high concentrations of total phenols, flavonoids, tannins, alkaloids than the pulp extracts. The ethanolic extract in both pulp and peel gave higher concentrations of phytochemical compounds than the ethyl acetate extract. Therefore, pulp and peel extract has antioxidant and antimicrobial activity against gram positive, negative bacteria and fungus. Also, the percentage of Liver cell line (HepG2), Colorectal adenocarcinoma (Caco-2) and Breast cell line (MCF-7) viability was decreased with increasing the concentrations of the ethanolic extract of the pulp and peel cactus (500, 1000, 1500, 2000, 3000 ^g/ml). The most pronounced reduction in the viability of cancer cells was detected after treatment with pulp extract than peel extract. The high concentrations of ethanolic extract of the pulp and peel cactus caused the high reduction in the viability of cancer cells especially in Liver cell line (HepG2). In addition, the phytochemical compound screened by GC-MS method. In this GC-MS analysis, 31 bioactive phytochemical compounds were identified in the pulp of cactus and 27 bioactive compounds were detected in peel extract. These different active phytochemicals have been found to possess a wide range of activities, which may help in the protection against incurable diseases. 2019 Parlar Scientific Publications. All rights resreved.