Faculty Of Dentistry Research Paper

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Browsing Faculty Of Dentistry Research Paper by Author "6th October"

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    Ki-67 expression in gingival overgrowth: An immunohistochemical study
    (2011) El-Firt E.Y.; Ghalwash D.M.; Departement of Oral Medicine and Periodontology; Faculty of Oral and Dental Medicine; Cairo University; Cairo; Egypt; Departement of Oral Medicine and Periodontology; Faculty of Dentistry; October University for Modern Sciences and Arts; 6th October; Egypt
    Ki-67 is a well-recognized nuclear proliferation marker. Considering that an unusual cell proliferation may have a role in the pathogenesis of gingival overgrowth with different etiologies. The study involved 4 patients with cyclosporine induced gingival overgrowth (CGO), 6 patients with phenytoin induced GO (PGO) and 5 patients with hereditary gingival fibromatosis (HGF). Healthy tissue samples without clinical signs of periodontal inflammation were also included as control samples. Immunohistochemistry against the proliferation antigen Ki-67 was performed and optical density measured and compared in both epithelium and connective tissue. Ki-67 was expressed both in the epithelium and corium of the four studied groups. The expression patterns of Ki-67 were significantly higher (p<0.00) in CGO, while no significant difference between HGF and PGO groups was detected and both showed lower values than CGO. Control group showed the significantly lowest mean of Ki-67 level and the expression was mainly in the basal layer of epithelium. In conclusion; increased cell division may have a role in the pathogenesis of gingival overgrowth induced by cyclosporine and phenytoin or inherited as HGF as reflected by increased expression of Ki-67.