Faculty Of Pharmacy Graduation Project 2018 - 2019

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Browsing Faculty Of Pharmacy Graduation Project 2018 - 2019 by Author "Ahmed Elfawal, Alaa"

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    ANTI-OBESITY ACTIVITY OF THE AQUOEUS EXTRACT OF MORINGA OLIFERA HERBAL TEAS FAMILY MORINGACEAE (RSPG2.6)
    (October University for Modern Sciences and Arts, 2019) Ahmed Elfawal, Alaa; Gamal Rabea, Elbadry; Mohamed Elsied, Mrehan; Adel Mohamed, Noha
    Obesity is a serious disease, means specifically to have an abnormal high proportion of fat, It is a common complex, multifactorial dependent and largely preventable disease. This metabolic disease results from lack of physical activity, excessive eating, gall stone, frequency of pregnancy, physiological factors or it may be inherited. If it left untreated it may lead to serious complications such as cardiovascular, lung diseases, arthritis and cancer. Nowadays people tend to replace conventional methods of treatment including drugs and surgeries with herbal medicine due to its effective cost and reduced side effects. One of the effective herbal plants is Moringa oleifera Lam. (Moringaceae).The aim of this study is to conduct a phytochemical investigation of aqueous extracts of M. oleifera herbal teas as M. oleifera alone, M. oleifera with lemon peels and M. oleifera with Mentha leaves. In addition to evaluate their anti-obesity and antihypercholesterolemic activities in a high fat diet induced obesity model in rats. Chromatographic analyses using LC-ESI-MS-MS apparatus revealed that the common major compounds found in M. oleifera alone, M. oleifera with lemon peels and M. oleifera with Mentha leaves extracts were Quercetin , Spiraeoside and L-Phenylalanine. This in vivo study was tested using daily oral doses of 200 mg/kg and 400 mg/kg for 1 month and compared to Simvastatin. All extracts possessed a good antiobesity activity.