Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and/or textile finishing based on 2-n-acylamino-4,5,6,7-tetrahydrobenzo[b]thiophene systems

Shams H.Z.; Mohareb R.M.; Helal M.H.; Mahmoud A.E.-S.

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dc.contributor.author	Shams H.Z.
dc.contributor.author	Mohareb R.M.
dc.contributor.author	Helal M.H.
dc.contributor.author	Mahmoud A.E.-S.
dc.contributor.other	Department of Chemistry
dc.contributor.other	Faculty of Science
dc.contributor.other	Helwan University
dc.contributor.other	P.O. 11790
dc.contributor.other	Ain Helwan
dc.contributor.other	Cairo
dc.contributor.other	Egypt; Department of Organic Chemistry
dc.contributor.other	Faculty of Pharmacy
dc.contributor.other	October University for Modern Sciences and Arts
dc.contributor.other	P.O. 12613
dc.contributor.other	October City
dc.contributor.other	Egypt; Department of Chemistry
dc.contributor.other	Faculty of Science
dc.contributor.other	Cairo University
dc.contributor.other	Giza
dc.contributor.other	P.O. 12311
dc.contributor.other	Egypt
dc.date.accessioned	2020-01-25T19:58:30Z
dc.date.available	2020-01-25T19:58:30Z
dc.date.issued	2011
dc.identifier.issn	14203049
dc.identifier.other	https://doi.org/10.3390/molecules16086271
dc.identifier.other	PubMed ID 21792147
dc.identifier.uri	https://t.ly/b2RJA
dc.description	Scopus
dc.description.abstract	A series of novel polyfunctionalized acyclic and heterocyclic dye precursors and their respective azo (hydrazone) counterpart dyes and dye precursors based on conjugate enaminones and/or enaminonitrile moieties were synthesized. The dyes and their precursors are based on 2-cyano-N-(3-cyano-4,5, 6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide, 2-ethoxycarbonyl-N-(3-cyano-4,5, 6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide or 2-phenylcarbamoyl-N-(3-cyano- 4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide systems as precursors. The latter compounds were used to synthesize polyfunctional thiophene-, thiazole-, pyrazole, pyridine-, pyrimidine-, oxazine-, as well as acyclic moieties. The dyes and dye precursors were characterized by elemental analysis and spectral methods. All dyes and their precursors were screened in vitro and evaluated for both their antibacterial and antifungal activities. MIC data of the novel dye systems and their respective precursors showed significant antimicrobial activity against most tested organisms. Some compounds exhibited comparable or even higher efficiency than selected standards. Dyes were applied at 5% depth for disperse dyeing of nylon, acetate and polyester fabrics. Their spectral characteristics and fastness properties were measured and evaluated.	en_US
dc.description.uri	https://www.scimagojr.com/journalsearch.php?q=26370&tip=sid&clean=0
dc.language.iso	English	en_US
dc.relation.ispartofseries	Molecules
dc.relation.ispartofseries	16
dc.subject	Antimicrobial activity	en_US
dc.subject	Dyes	en_US
dc.subject	Fastness	en_US
dc.subject	Heterocyclic	en_US
dc.subject	Textile finish	en_US
dc.subject	acetamide derivative	en_US
dc.subject	ampicillin	en_US
dc.subject	antifungal agent	en_US
dc.subject	antiinfective agent	en_US
dc.subject	coloring agent	en_US
dc.subject	enaminonitrile	en_US
dc.subject	fused heterocyclic rings	en_US
dc.subject	nitrile	en_US
dc.subject	prodrug	en_US
dc.subject	pyrazole	en_US
dc.subject	pyrazole derivative	en_US
dc.subject	pyrimidine derivative	en_US
dc.subject	thiazole derivative	en_US
dc.subject	thiophene derivative	en_US
dc.subject	article	en_US
dc.subject	Bacillus cereus	en_US
dc.subject	Bacillus subtilis	en_US
dc.subject	Candida albicans	en_US
dc.subject	chemistry	en_US
dc.subject	drug design	en_US
dc.subject	drug effect	en_US
dc.subject	Escherichia coli	en_US
dc.subject	growth, development and aging	en_US
dc.subject	materials testing	en_US
dc.subject	microbiological examination	en_US
dc.subject	synthesis	en_US
dc.subject	textile	en_US
dc.subject	textile industry	en_US
dc.subject	Acetamides	en_US
dc.subject	Ampicillin	en_US
dc.subject	Anti-Bacterial Agents	en_US
dc.subject	Antifungal Agents	en_US
dc.subject	Bacillus cereus	en_US
dc.subject	Bacillus subtilis	en_US
dc.subject	Candida albicans	en_US
dc.subject	Coloring Agents	en_US
dc.subject	Drug Design	en_US
dc.subject	Escherichia coli	en_US
dc.subject	Heterocyclic Compounds, 2-Ring	en_US
dc.subject	Materials Testing	en_US
dc.subject	Microbial Sensitivity Tests	en_US
dc.subject	Nitriles	en_US
dc.subject	Prodrugs	en_US
dc.subject	Pyrazoles	en_US
dc.subject	Pyrimidines	en_US
dc.subject	Textile Industry	en_US
dc.subject	Textiles	en_US
dc.subject	Thiazoles	en_US
dc.subject	Thiophenes	en_US
dc.title	Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and/or textile finishing based on 2-n-acylamino-4,5,6,7-tetrahydrobenzo[b]thiophene systems	en_US
dc.type	Article	en_US
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dcterms.source	Scopus
dc.identifier.doi	https://doi.org/10.3390/molecules16086271
dc.identifier.doi	PubMed ID 21792147
dc.Affiliation	October University for modern sciences and Arts (MSA)