Chemical Composition and Biological Activities of the Essential Oil from Leaves and Flowers of Pulicaria incisa sub. candolleana (Family Asteraceae)

Shahat E.A.; Bakr R.O.; Eldahshan O.A.; Ayoub N.A.

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Chemical Composition and Biological Activities of the Essential Oil from Leaves and Flowers of Pulicaria incisa sub. candolleana (Family Asteraceae)

Shahat E.A.; Bakr R.O.; Eldahshan O.A.; Ayoub N.A.

Full Text link: https://t.ly/1VVwl

Date issued: 2017

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Doi: https://doi.org/10.1002/cbdv.201600156 PubMed ID 28094467

Publisher: Institute of Physics Publishing , Wiley-VCH Verlag

Series Info: Chemistry and Biodiversity
14

Type: Article

Keywords: October University for Modern Sciences and Arts , University for Modern Sciences and Arts , MSA University , جامعة أكتوبر للعلوم الحديثة والآداب , Antimicrobial activities , Cytotoxic activities , Essential oil , GC-MS Analysis , Pulicaria incisa sub. candolleana , 1 octen 3 ol , 1,2,4 trimethylbenzene , alpha thujene , amphotericin B , ampicillin , anethole , antibiotic agent , antifungal agent , beta pinene , bourbonene , camphene , carveol , cineole , copaene , cytotoxic agent , essential oil , gentamicin , hexanal , hexanol , hexobarbital , jasmone , lauric acid , palmitic acid isopropyl ester , pinene , sabinene , sesquiterpene , terpinen 4 ol , terpinene , unindexed drug , vinblastine sulfate , antifungal agent , antiinfective agent , antineoplastic agent , borane derivative , chrysanthenone , essential oil , antibacterial activity , antifungal activity , Article , Aspergillus fumigatus , Bacilli , Bacillus subtilis , bacterial strain , Candida albicans , chemical composition , comparative study , concentration response , controlled study , cytotoxicity , Escherichia coli , flower , fungal strain , Geotricum candidum , Hep-G2 cell line , IC50 , minimum inhibitory concentration , MTT assay , nonhuman , plant leaf , Pseudomonas aeruginosa , Pulicaria , Pulicaria incisa sub. candolleana , Pulicaria inuloides , Pulicaria jaubertii , Pulicaria stephanocarpa , Streptococcus pneumoniae , Syncephalastrum racemosum , chemistry , drug effects , Egypt , flower , Gram negative bacterium , Gram positive bacterium , human , isolation and purification , mass fragmentography , microbial sensitivity test , plant leaf , Pulicaria , Anti-Bacterial Agents , Antifungal Agents , Antineoplastic Agents , Boranes , Egypt , Flowers , Gas Chromatography-Mass Spectrometry , Gram-Negative Bacteria , Gram-Positive Bacteria , Hep G2 Cells , Humans , Microbial Sensitivity Tests , Oils, Volatile , Plant Leaves , Pulicaria

Abstract:

The composition of the essential oil isolated from leaves and flowers of Pulicaria incisa sub. candolleana E. Gamal-Eldin, growing in Egypt, was analysed by GC and GC-MS. Forty-nine and 68 compounds were identified from the oils of the leaves and flowers accounting for 86.69 and 84.29%, respectively of the total detected constituents. Both leaves and flowers oils were characterized by the high content of carvotanacetone with 66.01, 50.87 and chrysanthenone 13.26, 24.3%, respectively. The cytotoxic activity of both essential oils was evaluated against hepatocellular carcinoma cell line HEPG-2, using MTT assay and vinblastine as a reference drug. Leaf oil showed higher activity with IC50 11.4�?g/ml compared with 37.4�?g/ml for flower oil. The antimicrobial activity of both oils was evaluated using agar well diffusion method towards two representatives for each of Gram positive and Gram negative bacteria as well as four representatives for fungi. The minimum inhibitory concentration of both essential oils against bacterial and fungal strains was obtained in the range of 0.49��15.63�?g/ml. � 2017 Wiley-VHCA AG, Zurich, Switzerland