The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

Mohareb R.M.; Mohamed A.A.

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The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

Mohareb R.M.; Mohamed A.A.

Full Text link: https://t.ly/epMqO

Date issued: 2010

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Doi: https://doi.org/10.3390/molecules15053602 PubMed ID 20657502

Series Info: Molecules
15

Type: Article

Keywords: 1,3,4-triazine , Antitumor , Hydrazide-hydrazone , Pyridazine , Pyridine , acetohydrazide , acetophenone , acetophenone derivative , antineoplastic agent , heterocyclic compound , hydrazine derivative , pyridine , pyridine derivative , triazine derivative , acetophenone derivative , antineoplastic agent , heterocyclic compound , hydrazine derivative , article , chemistry , drug screening , human , structure activity relation , synthesis , tumor cell culture , chemistry , synthesis , Acetophenones , Antineoplastic Agents , Drug Screening Assays, Antitumor , Heterocyclic Compounds , Humans , Hydrazines , Pyridines , Structure-Activity Relationship , Triazines , Tumor Cells, Cultured , Acetophenones , Antineoplastic Agents , Drug Screening Assays, Antitumor , Heterocyclic Compounds , Humans , Hydrazines , Pyridines , Structure-Activity Relationship , Triazines , Tumor Cells, Cultured

Abstract:

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.