• A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma 

  Assal, Reem A; Elemam, Noha M; Mekky, Radwa Y; Attia, Abdelrahman A; Soliman, Aya Hesham; Gomaa, Asmaa Ibrahim; Efthimiadou, Eleni K; Braoudaki, Maria; Fahmy, Sherif Ashraf; Youness, Rana A (Neoplasia Press, Inc, 2024-04)

  Tumor microenvironment is an intricate web of stromal and immune cells creating an immune suppressive cordon around the tumor. In hepatocellular carcinoma (HCC), Tumor microenvironment is a formidable barrier towards novel ...
• Plant-Polyphenol-Mediated Synthesis of Magnetic Biocompatible Iron Oxide Nanoparticles for Diagnostic Imaging and Management of Neurodegenerative Diseases 

  Abdelmonem, Mohamed; Albert, Emmellie Laura; Alhadad, Maha A; Abdullah, Che Azurahanim Che (Andover House, Inc, 2024-04)

  Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and glioblastoma tumors (GB), represent a spectrum of disorders characterized by progressive neuronal degeneration. This ...
• Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights 

  Ezzat, Shahira M; Merghany, Rana M; Abdel Baki, Passent M; Abdelrahim, Nariman Ali; Osman, Sohaila M; Salem, Mohamed A; Peña-Corona, Sheila I; Cortés, Hernán; Kiyekbayeva, Lashyn; Leyva-Gómez, Gerardo; Sharifi-Rad, Javad; Calina, Daniela (Wiley-VCH Verlag, 2024-04)

  Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of ...
• Lipid nanocapsules: A Novel Strategy for Brain Targeting via Nasal Administration 

  IBRAHIM, Mennatullah; BASALIOUS, Emad; El-NABARAWI, Mohamed; MAKHLOUF, Amal (Marmara University, 2024-03)

  In spite of the great advance in drug delivery systems (DDSs) for the control of the neurological disorders like Alzheimer's disease, Parkinson's disease, epilepsy and seizures, yet there is a demand for innovative DDSs ...
• Evaluation and formulation of Spirulina platensis proteins for potential applications in hair care products 

  Elkady, Omar A; Mannaa, Islam M; El Bishbishy, Mahitab H (Springer Nature, 2024-03)

  Spirulina platensis, a blue-green algae belonging to family Phormidiaceae, is well-known for its unique nutritional profle and high protein content. This study aims to isolate its proteins, formulate them into a cream ...
• Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients 

  ., Azza Gaber Antar Farag a, Eman Abd-Elfatah Badr b, Banan Mohamed Gamal Abd-Elaty c, Nada Farag Elnaidany d, Mai Medhat Mohamed Ghanem a, (Elsevier BV, 2024-03)

  Background: Alopecia Areata (AA) is an acquired autoimmune form of non-scarring hair loss. Adiponectin and its gene polymorphism were related to many autoimmune disorders. Objective: Assessment of adiponectin serum levels ...
• Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic 

  Afify, Fatma A; Shata, Ahmed H; Aboelnaga, Nirmeen; Osama, Dina; Elsayed, Salma W; Saif, Nehal A; Mouftah, Shaimaa F; Shawky, Sherine M; Mohamed, Ahmed A; Loay, Omar; Elhadidy, Mohamed (Academy of Scientific Research and Technology, 2024-03)

  The current study investigated the temporal phenotypic and genotypic antimicrobial resistance (AMR) trends among multi‐drug resistant and carbapenem‐resistant Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas ...
• Atorvastatin loaded lecithin‑coated zein nanoparticles based thermogel for the intra‑articular management of osteoarthritis: in‑silico, in‑vitro, and in‑vivo studies 

  Elgendy, Heba Amin ; Makky, Amna M. A; Elakkad, Yara E; Awad, Heba H;  El Hassab, Mahmoud A; Younes, Nihal Farid  (Springer Netherlands, 2024-02)

  Purpose Up-to-date literature ofers limited data about utilizing atorvastatin calcium (ATV) as a promising chondroprotective agent in osteoarthritis (OA). So, this study aims to develop a depot intra-articular (IA) ...
• Development of antifungal fibrous ocular insert using freeze‑drying technique 

  Teba, Hoda E; Khalil, Islam A; Gebreel, Rana M; Fahmy, Lamiaa I; El Sorogy, Heba M (Springer Publishing Company, 2024-01)

  Candida species is one of the pathogenic fungi of the eye responsible for keratitis that frequently causes vision impairment and blindness. Effective treatment requires long-term use of antifungal drugs, which is opposed ...
• Ezetimibe-Loaded Nanostructured Lipid Carrier for Oral Delivery: Response Surface Methodology; In Vitro Characterization and Assessing the Antihyperlipidemic Effect in Rats 

  Elkhayat, Dalia; Abdelmalak, Nevine S; Amer, Reham; Awad, Heba H (American Chemical Society, 2024-02)

  Among the independent risk factors for the occurrence of cardiovascular diseases like atherosclerosis is hyperlipidemia. To decrease cardiovascular events and patient mortality, antihyperlipidemia therapy is crucial. ...
• Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen 

  Amer, Mai A; Darwish, Manal M; Soliman, Noha S; Amin, Heba M (Frontiers Media S.A., 2024-02)

  Coagulase-negative staphylococci (CoNS) are a group of gram-positive staphylococcal species that naturally inhabit the healthy human skin and mucosa. The clinical impact of CoNS-associated infections has recently ...
• Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study 

  Ibrahim, Mennatullah M; Basalious, Emad B; El‑Nabarawi, Mohamed A; Makhlouf, Amal IA; Sayyed, Marwa Eid ; Ibrahim, Ismail Taha  (Springer Publishing Company, 2024-01)

  Mirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low bioavailability, which is only 50%, in spite of its rapid absorption when orally administered owing to high first-pass metabolism. ...
• Chewing gum containing repaglinide solid dispersion using mesoporous silica nanoparticles for management of diabetes mellitus: In-vitro evaluation and clinical appraisal 

  Badawi, Noha M; Amer, Reham I; Attia, Dalia A; Fayez, Ahmed M; Dawoud, Marwa H.S (Editions de Sante, 2024-02)

  The current study aimed to formulate repaglinide solid dispersion via mesoporous silica nanoparticles (R-MSNs) as a carrier in an attempt to enhance drug solubility. Then incorporation of it in a medicated chewing gum ...
• Green and white-assessed validated chromatographic methods for Ondansetron purity testing in its pharmaceutical formulations; in silico toxicity profiling of impurities 

  El-Maraghy, Christine M; Nour, Mai S; ELbalkiny, Heba T (Elsevier Inc, 2024-02)

  Drug impurities are seen as a crucial threat to drug safety, specifically when dealing with mutagenic/ toxic impurities. Here, we present LC-MS/MS and HPTLC-densitometric methods for simultaneous quantification of Ondansetron ...
• Exploiting response surface D‑optimal design study for preparation and optimization of spanlastics loaded with miconazole nitrate as a model antifungal drug for topical application 

  Ibrahim, Mervat Shafik ; Elkady, Omar A; Amer, Mai A; Noshi, Shereen H (Springer New York, 2023-12)

  Purpose Skin fungal infections are widely spreading worldwide and are considered a main cause of skin, mucous membranes, and systemic diseases. In an approach to enhance the topical delivery of miconazole nitrate (MZN) ...
• Investigations of new N1-substituted pyrazoles as anti-inflammatory and analgesic agents having COX inhibitory activity 

  Said, Mona F; George, Riham F; Fayed, Walid; Soliman, Ahmed A F; Refaey, Rana H (Future Science, 2024-01)

  Background: The search is ongoing for ideal anti-inflammatory and analgesic agents with promising potency and reasonable selectivity. Methods: New N1-substituted pyrazoles with or without an acetamide linkage ...
• Preparation and in vivo evaluation of nano sized cubosomal dispersion loaded with Ruta graveolens extracts as a novel approach to reduce asthma-mediated lung inflammation 

  Alyami, Mohammad H; Hamdan, Dalia I; Khalil, Heba M.A; Orabi, Mohamed A.A; Aborehab, Nora M; Osama, Nada; Abdelhafez, Mai M; Al-Mahallawi, Abdulaziz Mohsen; Alyami, Hamad S (King Saud University, 2024-02)

  Asthma is a chronic disease affecting people of all ages. Asthma medications are associated with adverse effects restricting their long-term usage, demanding newer alternative therapies. This study aimed to investigate ...
• Comparative genomic analysis of strong biofilm-forming Klebsiella pneumoniae isolates uncovers novel ISEcp1-mediated chromosomal integration of a full plasmid-like sequence 

  Hamed, Samira M; Mohamed, Hend O; Ashour, Hossam M; Fahmy, Lamiaa I (Taylor and Francis Ltd, 2024-01)

  Background: The goal of the current study was to elucidate the genomic background of biofilm formation in Klebsiella pneumoniae. Methods: Clinical isolates were screened for biofilm formation using the crystal violet assay. ...
• Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology 

  Elemam, Noha M; Mekky, Radwa Y; Rashid, Gowhar; Braoudaki, Maria; Youness, Rana A (Cambridge University Press, 2024-01)

  The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion ...
• Guidelines for accurate application of green and white analytical concepts: Merits Versus demerits with insights of significant milestones of assessment tools applied for antiviral drugs 

  Saleh, Sarah S; Obaydo, Reem H; El Hamd, Mohamed A; Rostom, Yasmin; Mohamed, Dalia; Lotfy, Hayam M (Elsevier Inc, 2024-01)

  In recent years, there has been a growing focus in analytical research on the ecological and sustainable aspects of analytical methodologies. However, it is necessary to apply the relevant metrics to evaluate the ...

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