I-131 doping of silver nanoparticles platform for tumor theranosis guided drug delivery
Sakr T.M.; Khowessah O.M.; Motaleb M.A.; Abd El-Bary A.; El-Kolaly M.T.; Swidan M.M.
Date issued:
2018
Publisher:
Elsevier B.V.
Series Info:
European Journal of Pharmaceutical Sciences
122
Type:
Article
Keywords:
October University for Modern Sciences and Arts
,
University for Modern Sciences and Arts
,
MSA University
,
جامعة أكتوبر للعلوم الحديثة والآداب
,
And nano-sized radiopharmaceutical
,
Chelator free radiolabeling
,
Radiochemical doping
,
Silver nanoparticles
,
Theranostics
,
Tumor delivery
,
iodine 131
,
macrogol
,
silver nanoparticle
,
Iodine-131
,
metal nanoparticle
,
radioactive iodine
,
silver
,
animal cell
,
animal experiment
,
animal model
,
animal tissue
,
Article
,
cancer chemotherapy
,
cell viability
,
controlled study
,
cytotoxicity
,
doping
,
drug delivery system
,
Fourier transform infrared spectroscopy
,
human
,
human cell
,
in vitro study
,
in vivo study
,
isotope labeling
,
macrophage
,
male
,
mouse
,
nanoencapsulation
,
nanotechnology
,
nonhuman
,
photon correlation spectroscopy
,
priority journal
,
single drug dose
,
solid malignant neoplasm
,
surface plasmon resonance
,
theranostic nanomedicine
,
transmission electron microscopy
,
ultraviolet visible spectroscopy
,
WI-38 cell line
,
zeta potential
,
animal
,
cell line
,
cell survival
,
chemistry
,
drug effect
,
drug release
,
drug stability
,
metabolism
,
sarcoma
,
theranostic nanomedicine
,
tissue distribution
,
Animals
,
Cell Line
,
Cell Survival
,
Drug Delivery Systems
,
Drug Liberation
,
Drug Stability
,
Humans
,
Iodine Radioisotopes
,
Male
,
Metal Nanoparticles
,
Mice
,
Sarcoma
,
Silver
,
Theranostic Nanomedicine
,
Tissue Distribution
Abstract:
Nanotechnology may be applied in medicine where the utilization of nanoparticles (?100 nm) for the delivery and targeting of theranostic agents is at the forefront of projects in cancer nano-science. This study points a novel one step synthesis approach to build up polyethylene glycol capped silver nanoparticles doped with I-131 radionuclide (131I-doped Ag-PEG NPs). The formula was prepared with average hydrodynamic size 21 nm, zeta potential � 25 mV, radiolabeling yield 98 � 0.76%, and showed good in-vitro stability in saline and mice serum. The in-vitro cytotoxicity study of cold Ag-PEG NPs formula as a drug carrier vehicle showed no cytotoxic effect on normal cells (WI-38 cells) at a concentration below 3 ?L/104 cells. The in-vivo biodistribution pattern of 131I-doped Ag-PEG NPs in solid tumor bearing mice showed high radioactivity accumulation in tumor tissues with maximum uptake of 35.43 � 1.12 and 63.8 � 1.3% ID/g at 60 and 15 min post intravenous (I.V.) and intratumoral injection (I.T.), respectively. Great potential of T/NT ratios were obtained throughout the experimental time points with maximum ratios 45.23 � 0.65 and 92.46 � 1.02 at 60 and 15 min post I.V. and I.T. injection, respectively. Thus, 131I-doped Ag-PEG NPs formulation could be displayed as a great potential tumor nano-sized theranostic probe. � 2018 Elsevier B.V.
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