Burn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. In the present study, a dressing coated with silver sulfadiazine (SSD) loaded chitosan nanoparticles (CSNPs) for the controlled-release of SSD into burn wound to control bacterial growth was investigated. CSNPs were formulated with different concentrations of chitosan and CM-?-CD and loaded with SSD complexed in 1:1 molar ratio with CM-?-CD, CSNPs were assessed for their particle size, polydispersity index, morphology and association efficiency. The formula showing the best characteristics was selected for the preparation of SSD loaded CSNPs wound dressing through a padding process with/without the use of cross-linker. The dressing was characterized for its physical properties, in addition, FTIR, X-ray, SEM and in vitro release were used for characterization. The dressing was proven effective for the inhibition of the growth of Gram positive and Gram negative bacteria as well as candida on an infected wound. 2016 Elsevier Ltd
Burn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. The aim of the present study is to formulate and ...
Haggag E.G.; Elshamy A.M.; Rabeh M.A.; Gabr N.M.; Salem M.; Youssif K.A.; Samir A.; Bin Muhsinah A.; Alsayari A.; Abdelmohsen U.R.(Dove Medical Press Ltd., 2019)
Background: Viral and microbial infections constitute one of the most important life-threatening problems. The emergence of new viral and bacterial infectious diseases increases the demand for new therapeutic drugs. Purpose: ...
Nanotechnology may be applied in medicine where the utilization of nanoparticles (?100 nm) for the delivery and targeting of theranostic agents is at the forefront of projects in cancer nano-science. This study points a ...