Improving dermal delivery of the ketoconazole via loading into bilosomal vesicles (RSPT2.21)

Abstract

The advancement in nanotechnologies issued an improvement in its application in medicine as well which is why this prospective study aims to encapsulate a medication called ketoconazole which is insoluble in water and anti-mycotic drug into a new nano- vesicles called bilosomes for attaining enhanced dermal delivery. The bilosomes is formulated from span 60, bile salt and cholesterol. In this study ketoconazole was loaded into bilosomes using a technique called ethanol injection method. As stated in 23 full factorial design that is to say eight formulations form B1 to B8. The examination of the effect of variable preparations variables on bilosomes characteristics and choice of the perfect preparation was done by the utilization of a program called Design Expert®. The chosen bilosomal preparation (B8 constitutes of 112.5 milligrams of span 60,37.5 milligrams of cholesterol and 40 milligrams of bile salt which is sodium cholate). Results has shown that the perfect preparation showed greater in vivo pass of the drug through the skin of the wistar rats while compared with the traditional nano vesicles like niosomes, and the suspension of this medication. Later on, in the histopathological, vivo skin studies done using male wistar rats has showed that the formulated bilosomal carrier is safe to be applied on the skin. Generally, the attained results established that bilosomal carrier could be a promising carrier for the skin delivery in the future.