Cinnamic acid Attenuates Cisplatin-Induced Hepatotoxicity and Nephrotoxicity

Abstract

We investigated the effects of cinnamic acid (CA, 20 mg/kg body weight) oncisplatin (CP)-induced hepto and nephrotoxicity in mice. CP (5 mg/kg bwt) wasinjected intraperitoneally and CA was given by gastric gavage for 5 days pre- andpost-CP injection. After 5 days of CP injection, CP-induced injuries of the hepaticand renal tissues which were evidenced (i) histopathological damage of the hepaticand renal tissues, (ii) as increases in liver and kidney function parameters, (iii) asincreases in lipid peroxidation and nitric oxide, and (iv) as decrease in glutathionecontent. In contrast, the oral administration of CA concurrently to CP intoxicatedmice brought back lipid peroxidation, nitric oxide, glutathione levels to nearnormalcy. Moreover, the histological observations evidenced that CA effectivelyrescues the liver and kidney from CP mediated oxidative damage. Therefore,cinnamic acid can be considered a potential candidate for protection of hepato-andnephrotoxicity induced by cisplatin.