The potential protective effect of physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAl-Olayan E.M.
dc.contributor.authorEl-Khadragy M.F.
dc.contributor.authorAref A.M.
dc.contributor.authorOthman M.S.
dc.contributor.authorKassab R.B.
dc.contributor.authorAbdel Moneim A.E.
dc.contributor.otherZoology Department
dc.contributor.otherFaculty of Science
dc.contributor.otherKing Saud University
dc.contributor.otherRiyadh 11451
dc.contributor.otherSaudi Arabia; Zoology and Entomology Department
dc.contributor.otherFaculty of Science
dc.contributor.otherHelwan University
dc.contributor.otherCairo 11795
dc.contributor.otherEgypt; Biological Science Department
dc.contributor.otherFaculty of Dentistry
dc.contributor.otherModern Sciences and Arts (MSA) University
dc.contributor.otherGiza 12111
dc.contributor.otherEgypt; Biochemistry and Molecular Biology Department
dc.contributor.otherFaculty of Biotechnology
dc.contributor.otherModern Sciences and Arts (MSA) University
dc.contributor.otherGiza 12111
dc.contributor.otherEgypt; Experimental Biology Department
dc.contributor.otherFaculty of Science
dc.contributor.otherMasaryk University
dc.contributor.other62500 Brno
dc.contributor.otherCzech Republic; Biochemistry and Molecular Biology Department
dc.contributor.otherAsturias Institute of Biotechnology
dc.contributor.otherUniversity of Oviedo
dc.contributor.other33006 Oviedo
dc.contributor.otherSpain
dc.date.accessioned2020-01-09T20:42:19Z
dc.date.available2020-01-09T20:42:19Z
dc.date.issued2014
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThe active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats divided into 4 groups: Group I served as control group, and Group II received weekly i.p. injection of 2 mL CCl4/kg bwt for 12 weeks. Group III were supplemented with Physalis juice via the drinking water. The animals of Group IV received Physalis juice as Group III and also were intraperitoneally injected weekly with 2 mL CCl4/kg bwt for 12 weeks. Hepatoprotective effect was evaluated by improvement in liver enzymes serum levels, reduction in collagen areas, downregulation in expression of the fibrotic marker MMP-9, reduction in the peroxidative marker malonaldehyde and the inflammatory marker nitric oxide, and restoration of the activity of antioxidant enzymatic and nonenzymatic systems, namely, glutathione content, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase activities. The results show that the potential hepatoprotective effects of Physalis peruviana may be due to physalis acts by promotion of processes that restore hepatolobular architecture and through the inhibition of oxidative stress pathway. � 2014 Ebtisam M. Al-Olayan et al.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19700175026&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1155/2014/381413
dc.identifier.doiPubMed ID : 24876910
dc.identifier.issn19420900
dc.identifier.otherhttps://doi.org/10.1155/2014/381413
dc.identifier.otherPubMed ID : 24876910
dc.identifier.urihttps://t.ly/LXXGm
dc.language.isoEnglishen_US
dc.publisherElsevier Ltd.
dc.publisherLandes Bioscienceen_US
dc.relation.ispartofseriesOxidative Medicine and Cellular Longevity
dc.relation.ispartofseries2014
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectCarbon tetrachlorideen_US
dc.subjectFlavonoidsen_US
dc.subjectNitric oxideen_US
dc.subjectOxygenen_US
dc.subjectPeptidesen_US
dc.subjectPlants (botany)en_US
dc.subjectRestorationen_US
dc.subjectActive constituentsen_US
dc.subjectGlutathione contentsen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectGlutathione reductaseen_US
dc.subjectGlutathione-S-transferaseen_US
dc.subjectHepatoprotective effectsen_US
dc.subjectProtective effectsen_US
dc.subjectSuper oxide dismutaseen_US
dc.subjectRatsen_US
dc.subjectalanine aminotransferaseen_US
dc.subjectantioxidanten_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectcarbon tetrachlorideen_US
dc.subjectcatalaseen_US
dc.subjectgelatinase Ben_US
dc.subjectglutathioneen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectglutathione reductaseen_US
dc.subjectglutathione transferaseen_US
dc.subjectliver protective agenten_US
dc.subjectmalonaldehydeen_US
dc.subjectnitric oxideen_US
dc.subjectPhysalis peruviana extracten_US
dc.subjectplant extracten_US
dc.subjectquercetinen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectunclassified drugen_US
dc.subjectgelatinase Ben_US
dc.subjectmalonaldehydeen_US
dc.subjectnitric oxideen_US
dc.subjectoxidoreductaseen_US
dc.subjectplant extracten_US
dc.subjectprotective agenten_US
dc.subjectalanine aminotransferase blood levelen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantioxidant activityen_US
dc.subjectarticleen_US
dc.subjectaspartate aminotransferase blood levelen_US
dc.subjectcarbon tetrachloride-induced liver fibrosisen_US
dc.subjectcontrolled studyen_US
dc.subjectdown regulationen_US
dc.subjectdrug effecten_US
dc.subjectenzyme activityen_US
dc.subjectenzyme repressionen_US
dc.subjectfruit juiceen_US
dc.subjectimmunohistochemistryen_US
dc.subjectin vitro studyen_US
dc.subjectlipid peroxidationen_US
dc.subjectliver function testen_US
dc.subjectliver homogenateen_US
dc.subjectliver protectionen_US
dc.subjectmaleen_US
dc.subjectmass fragmentographyen_US
dc.subjectmedicinal planten_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectphysalis peruvianaen_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectanimalen_US
dc.subjectblooden_US
dc.subjectchemistryen_US
dc.subjectdrug effectsen_US
dc.subjectDrug-Induced Liver Injuryen_US
dc.subjectliveren_US
dc.subjectmetabolismen_US
dc.subjectpathologyen_US
dc.subjectPhysalisen_US
dc.subjecttoxicityen_US
dc.subjectWistar raten_US
dc.subjectAnimalsen_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectDown-Regulationen_US
dc.subjectDrug-Induced Liver Injuryen_US
dc.subjectLiveren_US
dc.subjectLiver Function Testsen_US
dc.subjectMaleen_US
dc.subjectMalondialdehydeen_US
dc.subjectMatrix Metalloproteinase 9en_US
dc.subjectNitric Oxideen_US
dc.subjectOxidative Stressen_US
dc.subjectOxidoreductasesen_US
dc.subjectPhysalisen_US
dc.subjectPlant Extractsen_US
dc.subjectProtective Agentsen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.titleThe potential protective effect of physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expressionen_US
dc.typeArticleen_US
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