The potential role of Azadirachta indica treatment on cisplatin-induced hepatotoxicity and oxidative stress in female rats

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorDkhil M.A.
dc.contributor.authorAl-Quraishy S.
dc.contributor.authorAref A.M.
dc.contributor.authorOthman M.S.
dc.contributor.authorEl-Deib K.M.
dc.contributor.authorAbdel Moneim A.E.
dc.contributor.otherDepartment of Zoology
dc.contributor.otherCollege of Science
dc.contributor.otherKing Saud University
dc.contributor.otherRiyadh 11451
dc.contributor.otherSaudi Arabia; Department of Zoology and Entomology
dc.contributor.otherFaculty of Science
dc.contributor.otherHelwan University
dc.contributor.otherCairo 11795
dc.contributor.otherEgypt; Biological Science Department
dc.contributor.otherFaculty of Dentistry
dc.contributor.otherModern Science and Arts University (MSA)
dc.contributor.otherGiza 12111
dc.contributor.otherEgypt; Biochemistry and Molecular Biology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern Science and Arts (MSA)
dc.contributor.otherGiza 12111
dc.contributor.otherEgypt; Molecular Drug Evaluation Department
dc.contributor.otherNational Organization for Drug Control and Research (NODCAR)
dc.contributor.otherGiza 12553
dc.contributor.otherEgypt; Department of Biochemistry and Molecular Biology
dc.contributor.otherAsturias Institute of Biotechnology
dc.contributor.otherUniversity of Oviedo
dc.contributor.otherOviedo 33006
dc.contributor.otherSpain
dc.date.accessioned2020-01-09T20:42:20Z
dc.date.available2020-01-09T20:42:20Z
dc.date.issued2013
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractAzadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randomly divided into four groups. CDDP was given to rats by intraperitoneal injection, while MNLE was given by oral gavage for 5 days after the CDDP injection. The injury and oxidative stress caused by CDDP on the liver and the effect of MNLE were evaluated by measuring (a) histological changes, (b) tissue biochemical oxidant and antioxidant parameters, and (c) investigating apoptosis markers immunohistochemically and by real time PCR. After treatment with MNLE, the histological damage and apoptosis induction caused by cisplatin were improved. Malondialdehyde and nitric oxide were significantly decreased; the antioxidant system, namely, glutathione content, glutathione-S-transferase, glutathione peroxidase, catalase, and superoxide dismutase activities were significantly elevated. In conclusion, MNLE may have a potential role when combined with cisplatin in chemotherapy to alleviate cisplatin-induced damage and oxidative stress in liver. 2013 Mohamed A. Dkhil et al.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19700175026&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1155/2013/741817
dc.identifier.doiPubMed ID : 24369490
dc.identifier.issn19420900
dc.identifier.otherhttps://doi.org/10.1155/2013/741817
dc.identifier.otherPubMed ID : 24369490
dc.identifier.urihttps://t.ly/DXXAY
dc.language.isoEnglishen_US
dc.relation.ispartofseriesOxidative Medicine and Cellular Longevity
dc.subjectantioxidanten_US
dc.subjectcaspase 3en_US
dc.subjectcaspase 9en_US
dc.subjectcatalaseen_US
dc.subjectcisplatinen_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectmessenger RNAen_US
dc.subjectplant extracten_US
dc.subjectprotective agenten_US
dc.subjectprotein Baxen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectanimalen_US
dc.subjectarticleen_US
dc.subjectAzadirachta indicaen_US
dc.subjectchemistryen_US
dc.subjectdrug effecten_US
dc.subjectenzymologyen_US
dc.subjectfemaleen_US
dc.subjectgene expression regulationen_US
dc.subjectgeneticsen_US
dc.subjectlipid peroxidationen_US
dc.subjectliveren_US
dc.subjectmetabolismen_US
dc.subjectoxidative stressen_US
dc.subjectpathologyen_US
dc.subjectphytotherapyen_US
dc.subjectplant leafen_US
dc.subjectraten_US
dc.subjecttoxic hepatitisen_US
dc.subjectWistar raten_US
dc.subjectAnimalsen_US
dc.subjectAntioxidantsen_US
dc.subjectAzadirachtaen_US
dc.subjectbcl-2-Associated X Proteinen_US
dc.subjectCaspase 3en_US
dc.subjectCaspase 9en_US
dc.subjectCatalaseen_US
dc.subjectCisplatinen_US
dc.subjectDrug-Induced Liver Injuryen_US
dc.subjectFemaleen_US
dc.subjectGene Expression Regulationen_US
dc.subjectLipid Peroxidationen_US
dc.subjectLiveren_US
dc.subjectNF-kappa Ben_US
dc.subjectOxidative Stressen_US
dc.subjectPhytotherapyen_US
dc.subjectPlant Extractsen_US
dc.subjectPlant Leavesen_US
dc.subjectProtective Agentsen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectRNA, Messengeren_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleThe potential role of Azadirachta indica treatment on cisplatin-induced hepatotoxicity and oxidative stress in female ratsen_US
dc.typeArticleen_US
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