An efficient synthesis of novel pyrazole-based heterocycles as potential antitumor agents
| dc.Affiliation | October University for modern sciences and Arts (MSA) | |
| dc.contributor.author | Abdallah M.A. | |
| dc.contributor.author | Gomha S.M. | |
| dc.contributor.author | Abbas I.M. | |
| dc.contributor.author | Kazem M.S.H. | |
| dc.contributor.author | Alterary S.S. | |
| dc.contributor.author | Mabkhot Y.N. | |
| dc.contributor.other | Department of Chemistry | |
| dc.contributor.other | Faculty of Science | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Giza | |
| dc.contributor.other | 12613 | |
| dc.contributor.other | Egypt; Department of Chemistry | |
| dc.contributor.other | Faculty of Dentistry | |
| dc.contributor.other | October University for Modern Science & Arts | |
| dc.contributor.other | Giza | |
| dc.contributor.other | 12613 | |
| dc.contributor.other | Egypt; Department of Chemistry | |
| dc.contributor.other | College of Science | |
| dc.contributor.other | King Saud University | |
| dc.contributor.other | P.O. Box 2455 | |
| dc.contributor.other | Riyadh | |
| dc.contributor.other | 11451 | |
| dc.contributor.other | Saudi Arabia | |
| dc.date.accessioned | 2020-01-09T20:41:19Z | |
| dc.date.available | 2020-01-09T20:41:19Z | |
| dc.date.issued | 2017 | |
| dc.description | Scopus | |
| dc.description.abstract | A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl-1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid. Similarly, two novel bipyridine derivatives were prepared by the above reaction using terephthaldehyde in lieu of benzaldehyde derivatives. In addition, a series of 1,2,4-triazolo[4,3-a]pyrimidines was synthesized by a reaction of 6-(pyrazol-3-yl)pyrimidine-2-thione with a number of hydrazonoyl chlorides in dioxane and in the presence of triethylamine. The structure of the produced compounds was established by elemental analyses and spectral methods, and the mechanisms of their formation was discussed. Furthermore, the pyrazolyl-pyridine derivatives were tested as anticancer agents and the results obtained showed that some of them revealed high activity against human hepatocellular carcinoma (HEPG2) cell lines. � 2017 by the authors. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=21100829268&tip=sid&clean=0 | |
| dc.identifier.doi | https://doi.org/10.3390/app7080785 | |
| dc.identifier.doi | PubMed ID : | |
| dc.identifier.issn | 20763417 | |
| dc.identifier.other | https://doi.org/10.3390/app7080785 | |
| dc.identifier.other | PubMed ID : | |
| dc.identifier.uri | https://t.ly/veeBY | |
| dc.language.iso | English | en_US |
| dc.publisher | MDPI AG | en_US |
| dc.relation.ispartofseries | Applied Sciences (Switzerland) | |
| dc.relation.ispartofseries | 7 | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | University of Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | Antitumor activity | en_US |
| dc.subject | Multicomponent reactions | en_US |
| dc.subject | Pyrazoles | en_US |
| dc.subject | Pyrazolyl-pyridines | en_US |
| dc.subject | Pyridines | en_US |
| dc.title | An efficient synthesis of novel pyrazole-based heterocycles as potential antitumor agents | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus |