Anti-diabetic Activity of Plants Belong to family Lythraceae (RS 502)(RSPG2.9)

Abstract

Diabetes mellitus is a chronic disorder which occurs due to deficiency of insulin leading to hyperglycemia with serious complications. So controlling blood glucose level is essential however synthetic drugs lead to serious adverse effect especially during pregnancy. So it has become our interest to find natural plant sources with similar antidiabetic activity but with lower side effect compared to synthetic drugs. Many plants belong to family Lythraceae have been previously reported for their antidiabetic activity due to their high phenolic content which have been reported to have antioxidant activity and the onset of diabetes is related to the increased oxidative stress. In view of this fact, a lot of Lythraceous plants have become our interest to estimate its in vitro antidiabetic activity and trying to find about the plant extract with the highest activity in order to investigate its in vivo antihyperglycemic effect. Ammannia aegyptiaca Willd. showed the highest pancreatic lipase, α- amylase and β-glucosidase inhibitory effect. In addition, it showed the highest free radical scavenging activity on (DPPH) and (ORAC) assay with the highest total phenolic and flavonoid contents. Experimenting on animals has been one of the effective strategies to develop new drugs, thus the in vivo antihyperglycemic effect was evaluated for the EtOH extract of this plant in STZ/HFD-induced diabetic male albino Wistar rats. Where, EtOH extract showed significant antihyperglycemic effect and its metabolic profiling was studied using LC-MS.