Promoting wound healing in diabetic rats

Abstract

Diabetes" mellitus is a heterogeneous metabolic "disorder which defined as an increase in blood" glucose "levels and it is a common cause of delaying the wound healing process. The aim of this study is to"" determine the effect of vitamin E and zinc separately and in combination on wound healing process in diabetic rats. Wound healing passes through four stages: homeostasis, inflammatory phase, proliferative phase, and remodeling stage. The study was" conducted by using 12 male Wistar albino rats that were divided into four groups: (I) diabetic"' control group, (II) diabetic rats" receiving vitamin E (400mg), (III) diabetic rats receiving zinc (5mg), (IV) diabetic rats receiving a combination of both zinc and vitamin E. Induction of diabetes was done by intra-peritoneal injection of single dose of STZ (65 mg/kg) and after 72 hours blood glucose was measured. Two" cutaneous wounds were created at the dorsal