CONTROL OF EXPERIMENTALLY INDUCED NEURODEGENERATIVE DISORDER BY THE USE OF A QUINOLINE DERIVATIVE IN RATS

Abstract

Introduction: Neurodegenerative diseases are the gradually loss of function and structure of the nervous cells in the brain. Patients suffer from difficulties in movement and mental health. Among the CNS diseases the Huntington’s disease was the main focus in this study in which it will be discussed thoroughly. Materials and Method: Adult albino wistar male rats were used divided into 3 experimental groups: Normal group rats treated with isotonic saline solution only, Control group rats treated with 3-nitropropionic acid (20 mg/kg/day) for 14 days via intra-peritoneal route and Treatment group rats treated with quinoline derivative drug for 21 days after 3-nitropropionic acid (20 mg/kg/day) for 14 days via intra-peritoneal route. Reagents used included Isotonic Saline solution, 3-nitropropionic acid and quinoline derivative drug. Behavioral tests and several biochemical tests were assessed and evaluated. Results: Our results showed that the biochemical parameters: Acetylcholine (Ach),

Serotonin (5HT3), Mammalian target of Rapamycin (mTOR) and Microtubule- associated protein IA/IB-light chain 3 (LC3-II) in treatment group had a higher than

control and closer to normal values and Tumor Necrosis Factor Alpha (TNF-alpha) and Calpain-2 in treatment group had a lower than control and closer to normal values. The results also showed that the behavioral tests: Open Field test, Novel Object Recognition Acquisition test (NOR) and Forced Swim test the treatment group covered more distance and mobility values were close to the normal group. Conclusion: The quinoline derivative treatment showed the potential pharmacological activity in improving the behavioral and recognition abilities as well as improved significantly the parameters which are usually reduced severely in neurodegenerative diseases and reduced significantly the inflammatory mediators to almost normal values.