The Therapeutic Effects of Mesenchymal Stem Cells and Taurine in Ovarian Dysfunction in Rat Model

Abstract

Chemotherapy targets rapidly dividing tissues in the body. It destroys the progenitor cells

in gonads resulting in ovarian dysfunction. Studies have suggested that bone marrow- derived stem cells can regenerate oocytes in chemotherapy-treated female rats after

transplantation. The present study aimed to assess mechanism of homing, the action of injected BM-MSCs and orally administered taurine on ovarian function after ovarian damage. Experimental design: Fifty female albino rats were randomly allocated into Control, CTX group, The Experimental protocol lasted for 10 weeks during which serum E2 and plasma serum ALT and MDA were monitored. Stem cells identification and homing were evaluated by Flowcytometry. Also, histopathological examination was done to evaluate both degeneration and regeneration of ovarian tissue. Principal observations: Paclitaxel group indicated noticeable ovarian distress. Partial improvement of E2, ALT and MDA levels as well as ovarian architecture. H&E staining showed that there were more healthy ovarian follicles after treatment with BM-MSCs and Taurine. Conclusion: Our results demonstrated that injected BM-MSCs can home in the stroma of the injured ovaries and alongside the supplementation of Taurine, injured ovarian function could be restored.