Effect of simvastatin versus low level laser therapy (LLLT) on bone regeneration in rabbit's tibia

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorGheith M.E.
dc.contributor.authorKhairy M.A.
dc.contributor.otherNational Institute of Laser Enhanced Sciences (N.I.L.E.S)
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Faculty of Oral and Dental Medicine
dc.contributor.otherOctober University for Modern Science and Arts
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:12Z
dc.date.available2020-01-09T20:42:12Z
dc.date.issued2014
dc.descriptionScopus
dc.description.abstractSimvastatin is a cholesterol lowering drug which proved effective on promoting bone healing. Recently low level laser therapy (LLLT) proved its effect as a biostimulator promoting bone regeneration. This study aims to compare the effect of both Simvastatin versus low level laser on bone healing in surgically created bone defects in rabbit’s tibia. Material and methods: The study included 12 New Zealand white rabbits. Three successive 3mm defects were created in rabbits tibia first defect was left as control, second defect was filled with Simvastatin while the third defect was acted on with Low Level Laser (optical fiber 320micrometer). Rabbits were sacrificed after 48 hours, 1 week and 2 weeks intervals. Histopathology was conducted on the three defects Results: The histopathologic studies showed that the bony defects treated with the Low Level Laser showed superior healing patterns and bone regeneration than those treated with Simvastatin. While the control defect showed the least healing pattern.en_US
dc.description.sponsorshipThe Society of Photo-Optical Instrumentation Engineers (SPIE)en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=130022&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1117/12.2036100
dc.identifier.doiPubMed ID :
dc.identifier.isbn9.78E+12
dc.identifier.issn16057422
dc.identifier.otherhttps://doi.org/10.1117/12.2036100
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/OXXYA
dc.language.isoEnglishen_US
dc.publisherSPIEen_US
dc.relation.ispartofseriesProgress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.relation.ispartofseries8929
dc.subjectBony defecten_US
dc.subjectDiode laser 980 nmen_US
dc.subjectSimvastatinen_US
dc.subjectBoneen_US
dc.subjectDentistryen_US
dc.subjectLaser surgeryen_US
dc.subjectOptical fibersen_US
dc.subjectBone regenerationen_US
dc.subjectBony defectsen_US
dc.subjectCholesterol loweringen_US
dc.subjectControl defectsen_US
dc.subjectLow level laseren_US
dc.subjectLow level laser therapyen_US
dc.subjectNew Zealand White rabbiten_US
dc.subjectSimvastatinen_US
dc.subjectDefectsen_US
dc.titleEffect of simvastatin versus low level laser therapy (LLLT) on bone regeneration in rabbit's tibiaen_US
dc.typeConference Paperen_US
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