Cyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinoma

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorBayomi E.A.
dc.contributor.authorBarakat A.B.
dc.contributor.authorEl-Bassuoni M.A.
dc.contributor.authorTalaat R.M.
dc.contributor.authorEl-Deftar M.M.
dc.contributor.authorWahab S.A.A.
dc.contributor.authorMetwally A.M.
dc.contributor.otherBotany and Genetics Department
dc.contributor.otherFaculty of Dentistry
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherEgypt; Medical Molecular Genetics Department
dc.contributor.otherHuman Genetics and Genome Research Division
dc.contributor.otherNational Research Center
dc.contributor.otherCairo
dc.contributor.otherEgypt; Microbiology Department
dc.contributor.otherFaculty of Science
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Clinical Pathology Department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia University
dc.contributor.otherAl Minufya
dc.contributor.otherEgypt; Microbiology and Immunology Department
dc.contributor.otherGenetic Engineering and Biotechnology Research Institute
dc.contributor.otherEl Sadat University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pathology Department
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Cancer Biology Department
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Technology of Medical Laboratory
dc.contributor.otherCollege of Applied Medical Sciences
dc.contributor.otherMisr University for Science and Technology
dc.contributor.otherP. O. Box 77
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:46Z
dc.date.available2020-01-09T20:41:46Z
dc.date.issued2015
dc.descriptionScopus
dc.description.abstractBackground: Cyclooxygenase-2 (COX-2), the inducible rate-limiting enzyme of prostaglandins biosynthesis, is involved in the pathogenesis of many chronic inflammation-related human malignancies including hepatocellular carcinoma (HCC). However, its clinical significance in HCC remains obscure. The aim of our study was to evaluate COX-2 expression in HCC and correlate its expression to both clinicopathological parameters and patients survival. Materials and Methods: The present study was conducted on 17 HCC and 21 adjacent nontumor liver tissues obtained from 22 HCC patients underwent hepatectomy. Eight normal liver tissues taken from normal donors and HepG2 cells were used as controls. Total RNA was extracted and COX-2 mRNA was detected by reverse transcription polymerase chain reaction and correlated to the clinicopathological criteria and to patient's survival. Results: COX-2 mRNA was detected in 58.8% of the HCC tissues and in 28.6% of the adjacent nontumor liver tissues. COX-2 expression was significantly associated with elevated levels of serum aspartate aminotransferase (AST) with high specificity for disease detection. There was no significance between COX-2 expression and any of the histopathological criteria. Conclusions: COX-2 expression may be involved in HCC carcinogenesis with high specificity for disease detection. COX-2 expression is significantly associated with elevated AST levels indicating a mechanism that may correlate both markers. However COX-2 expression seems to be an independent factor with no correlation to any of the histopathological data or patient's survival. � 2015 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=145443&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.4103/0973-1482.147692
dc.identifier.doiPubMed ID : 26881519
dc.identifier.issn9731482
dc.identifier.otherhttps://doi.org/10.4103/0973-1482.147692
dc.identifier.otherPubMed ID : 26881519
dc.identifier.urihttps://t.ly/Gggwb
dc.language.isoEnglishen_US
dc.publisherMedknow Publicationsen_US
dc.relation.ispartofseriesJournal of Cancer Research and Therapeutics
dc.relation.ispartofseries11
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectAspartate aminotransferaseen_US
dc.subjectcyclooxygenase-2en_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectsensitivityen_US
dc.subjectspecificityen_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectcyclooxygenase 2en_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectcyclooxygenase 2en_US
dc.subjectPTGS2 protein, humanen_US
dc.subjecttumor markeren_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectaspartate aminotransferase blood levelen_US
dc.subjectcancer prognosisen_US
dc.subjectcancer survivalen_US
dc.subjectcarcinogenesisen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdisease free survivalen_US
dc.subjectfemaleen_US
dc.subjectgene expressionen_US
dc.subjectHepG2 cell lineen_US
dc.subjecthistopathologyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjecthuman tissueen_US
dc.subjectliver cell carcinomaen_US
dc.subjectliver resectionen_US
dc.subjectmaleen_US
dc.subjectsensitivity and specificityen_US
dc.subjectcancer gradingen_US
dc.subjectCarcinoma, Hepatocellularen_US
dc.subjectcase control studyen_US
dc.subjectcomparative studyen_US
dc.subjectenzyme immunoassayen_US
dc.subjectfollow upen_US
dc.subjectgeneticsen_US
dc.subjectliveren_US
dc.subjectLiver Neoplasmsen_US
dc.subjectmetabolismen_US
dc.subjectmiddle ageden_US
dc.subjectpathologyen_US
dc.subjectprognosisen_US
dc.subjectsurvival rateen_US
dc.subjecttumor invasionen_US
dc.subjecttumor recurrenceen_US
dc.subjectAspartate Aminotransferasesen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectCarcinoma, Hepatocellularen_US
dc.subjectCase-Control Studiesen_US
dc.subjectCyclooxygenase 2en_US
dc.subjectFemaleen_US
dc.subjectFollow-Up Studiesen_US
dc.subjectHumansen_US
dc.subjectImmunoenzyme Techniquesen_US
dc.subjectLiveren_US
dc.subjectLiver Neoplasmsen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasm Gradingen_US
dc.subjectNeoplasm Invasivenessen_US
dc.subjectNeoplasm Recurrence, Localen_US
dc.subjectPrognosisen_US
dc.subjectSurvival Rateen_US
dc.titleCyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinomaen_US
dc.typeArticleen_US
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