(October university for modern sciences and arts, 2022) Khalil, Merna Samir Kamel; Abdelhamid, Mohamed Salah; Youseif, Nada Mohamed Zoheir; Amin, Noran Magdy Abdelmenuim
Cancer has been one of the main causes of mortality over the past few decades. 1,3,4-
Thiadiazole is a nitrogenous heterocyclic five-membered ring with several medicinal applications,
it is also known to possess potent anticancer activity through different mechanisms of action
allowing it to be used as a starting compound for designing anticancer drugs. In this study, some
novel 1,3,4-thiadiazole derivatives bearing thiazole ring were synthesized and screened for
cytotoxic activity and selectivity against breast (MCF-7), liver (HepG2), and normal (Vero) cell
lines using 5-Fluorouracil as a positive control. The tested compounds showed promising activity
with high selectivity indices
