Browsing by Author "Sherifa F. A. Moustafa"

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    A comparative UPLC‑orbitrap‑MS‑based metabolite profiling of three Pelargonium species cultivated in Egypt
    (Springer Nature, 2024-10-01) Rana M. Merghany; Mohamed A. Salem; Shahira M. Ezzat; Sherifa F. A. Moustafa; Salma A. El‑Sawi; Meselhy R. Meselhy
    Several Pelargonium species are cultivated mainly to produce essential oils used in perfume industry and for ornamental purposes. Although the chemical composition and biological activities of their essential oils were extensively investigated, there is limited information about the chemical composition of their non-volatile constituents. In this study, we report an Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)-based metabolomics approach for the annotation and analysis of various metabolites in three species; P. graveolens, P. denticulatum, and P. fragrans utilizing The Global Natural Product Social Molecular Networking (GNPS) and multivariate data analyses for clustering of the metabolites. A total of 154 metabolites belonging to different classes were annotated. The three species are good sources of coumarins, benzoic acid derivatives, organic acids, fatty acids, and phospholipids. However, the highest level of flavonols (mono- and di-O-glycosides) and cinnamic acid derivatives was found in P. graveolens and P. denticulatum, whereas tannins and flavone C-glycosides were abundant in P. fragrans. The metabolic profiles clarified here provide comprehensive information on the non-volatile constituents of the three Pelargonium species and can be employed for their authentication and possible therapeutic applications.
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    A comprehensive review of natural compounds and their structure–activity relationship in Parkinson’s disease: exploring potential mechanisms
    (Springer Nature, 2024-10-11) Rana M. Merghany; Salma A. El‑Sawi; Asmaa F. Aboul Naser; Shahira M. Ezzat; Sherifa F. A. Moustafa; Meselhy R. Meselhy
    Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopamine-producing cells in the Substantia nigra region of the brain. Complementary and alternative medicine approaches have been utilized as adjuncts to conventional therapies for managing the symptoms and progression of PD. Natural compounds have gained attention for their potential neuroprotective effects and ability to target various pathways involved in the pathogenesis of PD. This comprehensive review aims to provide an in-depth analysis of the molecular targets and mechanisms of natural compounds in various experimental models of PD. This review will also explore the structure–activity relationship (SAR) of these compounds and assess the clinical studies investigating the impact of these natural compounds on individuals with PD. The insights shared in this review have the potential to pave the way for the development of innovative therapeutic strategies and interventions for PD.