Browsing by Author "Salem M.A."

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    Insights into Eucalyptus genus chemical constituents, biological activities and health-promoting effects
    (Elsevier Ltd, 2019) Salehi B.; Sharifi-Rad J.; Quispe C.; Llaique H.; Villalobos M.; Smeriglio A.; Trombetta D.; Ezzat, Shahira M; Salem M.A.; Zayed A.; Salgado Castillo C.M.; Yazdi S.E.; Sen S.; Acharya K.; Sharopov F.; Martins N.; Student Research Committee; School of Medicine; Bam University of Medical Sciences; Bam; Iran; Zabol Medicinal Plants Research Center; Zabol University of Medical Sciences; Zabol; Iran; Instituto de EtnoFarmacolog�a; Facultad de Ciencias de la Salud; Universidad Arturo Prat; Avda. Arturo Prat 2120; Iquique; 1110939; Chile; Department of Chemical; Biological; Pharmaceutical and Environmental Sciences; University of Messina; Italy; Department of Pharmacognosy; Faculty of Pharmacy; Cairo University; Kasr El-Aini Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); 6th October 12566; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Menoufia University; Gamal Abd El Nasr st.; Shibin Elkom; Menoufia32511; Egypt; Department of Pharmacognosy; College of Pharmacy; Tanta University; Elguish Street; Tanta; 31527; Egypt; Facultad de Medicina; Universidad del Azuay; Cuenca; Ecuador; Department of Plant and Soil Sciences; University of PretoriaGauteng 0002; South Africa; Molecular and Applied Mycology and Plant Pathology Laboratory; Department of Botany; University of Calcutta; Kolkata; 700019; India; Department of Botany; Fakir Chand College; Diamond Harbour; West Bengal743331; India; Department of Pharmaceutical Technology; Avicenna Tajik State Medical University; Rudaki 139; Dushanbe; 734003; Tajikistan; Faculty of Medicine; University of Porto; Alameda Prof. Hernni Monteiro; Porto; 4200-319; Portugal; Institute for Research and Innovation in Health (i3S); University of Porto; Porto; 4200-135; Portugal
    Background: Eucalyptus genus members have received a great interest worldwide for their antibacterial, antiviral, antifungal, anti-inflammatory and insect-repellent properties for cosmetic, pharmaceutical, nutraceutical and furniture purposes. Indeed, the application of Eucalyptus essential oil in cosmetic and personal hygiene products is gradually increasing. Also, it has been widely used in the traditional medicine for centuries, in the treatment of respiratory diseases, common cold, influenza, and sinus congestion. Scope and approach: This review addressed botanical and ethnopharmacological aspects of Eucalyptus plants, as also its in vitro and in vivo pharmacological activities, and current insights with regards to clinical efficacy and safety. Key findings and conclusions: Eucalyptol (1,8-cineole) is the main component present in Eucalyptus oils. According to the previously reported uses of Eucalyptus oils and extracts, there is urgently required further in vivo studies with the distinct Eucalyptus constituents to reveal the secrets beyond the traditional uses for treatment of a wide spectrum of ailments. A great attention has also been given for its nanotechnological applications by food and pharmaceutical industries. Nanoemulsions containing Eucalyptus globulus oil have been recognized for its antimicrobial and antibiofilm effects against gram-negative bacteria and the major microorganism responsible for causing fungal infections worldwide (Candida albicans). Moreover, eucalyptol does not present genotoxicity or carcinogenicity. Subacute hepatotoxic and nephrotoxic effects in animal models have been stated after application of high doses, higher than the estimated LD50 (2400 mg/kg b.w. In rats). However, an in-deep risk assessment on further exposure and toxicity data is highly needed. 2019 Elsevier Ltd
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    Metabolomic profiling and biological investigation of Tabebuia Aurea (Silva Manso) leaves, family Bignoniaceae
    (Taylor and Francis Ltd., 2019) Mahmoud B.K.; Hamed A.N.E.; Samy M.N.; Abdelmohsen U.R.; Attia E.Z.; Fawzy M.A.; Refaey R.H.; Salem M.A.; Pimentel-Elardo S.M.; Nodwell J.R.; Desoukey S.Y.; Kamel M.S.; Department of Pharmacognosy; Faculty of Pharmacy; Minia University; Minia; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Deraya University; New Minia City; Egypt; Departmentof Biochemistry; Faculty of Pharmacy; Minia University; Minia; Egypt; Department of Pharmaceutical Chemistry; Faculty of Pharmacy; October University of Modern Sciences and Arts (MSA); Giza; Egypt; Department of Biochemistry; University of Toronto; Toronto; ON; Canada
    Both ethyl acetate and aqueous fractions of Tabebuia aurea leaves exhibited noteworthy antioxidant and nephroprotective activities against carbon tetrachloride (CCl4)-induced nephrotoxicity in rats, as evidenced by the remarkable improvements of renal serum biomarkers and histopathological features. Additionally, the ethyl acetate fraction displayed a prominent in vitro antitrypanosomal activity against Trypanosoma brucei; consequently, the leaves were subjected to LC-HR-ESI-MS metabolomic profiling to discover the constituents that possibly underlie their bioactivities. Therefore, ten metabolites were characterized, mostly dominated by flavonoids. Interestingly, two identified constituents viz., 3,9,12,15-octadecatetraenoic acid (9) and 9,11,13-octadecatrienoic acid (10) are reported firstly herein from the genus Tabebuia. Furthermore, among the dereplicated constituents, rutin (5) and kaempferol 3-O-rutinoside (6) exhibited the highest docking scores as effective antitrypanosomal compounds. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group.
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    New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies
    (Elsevier Masson SAS, 2019) El-Sayed N.A.; Nour M.S.; Salem M.A.; Arafa R.K.; Department of Pharmaceutical Chemistry; Faculty of Pharmacy; Cairo University; Kasr El-Aini Street; Cairo; 11562; Egypt; Department of Pharmaceutical Chemistry; Faculty of Pharmacy; October University of Modern Sciences and Arts (MSA); 6th; of October City; Giza; Egypt; Biomedical Sciences Program; Zewail City of Science and Technology; University of Science and Technology; October Gardens; 6th; of October City; Giza; 12578; Egypt; Drug Design and Discovery Laboratory; Helmy Institute of Science and Technology; Zewail City of Science and Technology; Cairo; 12578; Egypt
    Novel heterocyclic oxadiazoles viz. 2-subsituted-5-(4-pyridyl)-1,3,4-oxadiazoles, 2-subsituted-5-(3-pyridyl)-1,3,4-oxadiazoles and 2-subsituted-5-(phenyl or 4-chlorophenyl-1,3,4-oxadiazoles) were designed and synthesized as potential anticancer agents. In this investigation, all compounds were evaluated for their COX-1 and COX-2 inhibitory activity in vitro as new therapeutic approaches assumed cytotoxic effect associated with selective COX-2 inhibition. Results showed that most of the derivatives demonstrated inhibition towards both isoforms of COX comparable to the standard reference drugs indomethacin, diclofenac sodium and celecoxib. Then, nine selected compounds (IIId, VIb, VIIc, IX, XI, XIIa, XIVa, XVIb and XVIIIb) were subjected to cytotoxic screening against UO-31 renal cancer cell line using MTT assay. Compounds IIId, IX and XIIa displayed promising behavior by showing good anticancer activity. Moreover, kinase inhibitory assay against the tyrosine kinase EGFR was performed for the three compounds showing the highest cytotoxic activity. The tested compounds were potent against EGFR with the highest activity being observed for compound IX showing nearly double the potency of the reference drug Erlotinib. Moreover, molecular docking and molecular dynamics were performed for IIId, IX and XIIa against EGFR, in an attempt to elucidate a model for their binding at the molecular level, simulate and understand the possible binding interactions underlying the association between these small molecules and the kinase enzyme ATP binding pocket essential amino acids. Finally, in silico pharmacokinetic profile predication was investigated for IIId, IX and XIIIa using SWISS/ADME to identify the most promising small-molecule cytotoxic agent on the basis of displaying the best drug-like properties. Results indicated that compound IX has a potential to serve as a lead compound for developing novel anticancer therapeutic agents. � 2019 Elsevier Masson SAS