Browsing by Author "Salehi B."

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Athyrium plants - Review on phytopharmacy properties
(National Taiwan University, 2019) Salehi B.; Ezzat, Shahira M; Tsouh Fokou P.V.; Albayrak S.; Vlaisavljevic S.; Sharifi-Rad M.; Bhatt I.D.; Sharifi-Rad M.; Belwal T.; Ayatollahi S.A.; Kobarfard F.; Ata A.; Baghalpour N.; Martorell M.; Setzer W.N.; Sharifi-Rad J.; Student Research Committee; School of Medicine; Bam University of Medical Sciences; Bam; Iran; Pharmacognosy Department; Faculty of Pharmacy; Cairo University; Kasr El-Ainy Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Science and Arts (MSA)12566; Egypt; Department of Biochemistry; Faculty of Science; University of Yaounde 1; Po.Box 812; Yaounde; Cameroon; Department of Biology; Science Faculty; Erciyes University; Kayseri; 38039; Turkey; Department of Chemistry; Biochemistry and Environmental Protection; Faculty of Sciences; University of Novi Sad; Trg Dositeja Obradovica 3; Novi Sad; 21000; Serbia; Department of Range and Watershed Management; Faculty of Natural Resources; University of Zabol; Zabol; Iran; G.B. Pant National Institute of Himalayan Environment and Sustainable Development; Kosi-Katarmal; Almora; 263643; India; Department of Medical Parasitology; Zabol University of Medical Sciences; Zabol; Iran; Phytochemistry Research Center; Shahid Beheshti University of Medical Sciences; Tehran; Iran; Department of Chemistry; Richardson College for the Environmental Science Complex; The University of Winnipeg; 599 Portage Avenue; Winnipeg; MB R3B 2G3; Canada; Department of Medicinal Chemistry; School of Pharmacy; Shahid Beheshti University of Medical Sciences; Tehran; 11369; Iran; Department of Nutrition and Dietetics; Faculty of Pharmacy; University of Concepcion; Concepcion; Chile; Department of Chemistry; University of Alabama in Huntsville; Huntsville; AL 35899; United States; Food Safety Research Center (salt); Semnan University of Medical Sciences; Semnan; Iran
Athyrium plants consist of more than 230 species that are largely distributed in the Sino-Himalayan region and the Western Pacific islands. Athyrium species are being used in traditional medicine worldwide to treat various ailments such as cough, rheumatic pain, scorpion stings, sores, burns and scalds, intestinal fever, pain, specifically breast pain during child birth, to increase milk flow, as an antiparasitic, anthelmintic, and carminative. A deep look in the literature has revealed that Athyrium species have been poorly investigated for their food preservative applications and in vivo and in vitro biological and phytochemical studies. However, some Athyrium species have demonstrated antimicrobial, anti-inflammatory, antioxidant, antiproliferative and anti-HIV potential. Athyrium multidentatum (Doll.) Ching is the most investigated species and the biological activities of their extracts, such as they antioxidant properties, seem to be related to the sulfate contents of their polysaccharides. This review provides an update on the ethnopharmacology, phytochemistry and biological properties of Athyrium plants that might be useful for further research. Of course, well-designed clinical trials will be required for some species to be used as therapy. � 2018 Center for Food and Biomolecules, National Taiwan University
Insights into Eucalyptus genus chemical constituents, biological activities and health-promoting effects
(Elsevier Ltd, 2019) Salehi B.; Sharifi-Rad J.; Quispe C.; Llaique H.; Villalobos M.; Smeriglio A.; Trombetta D.; Ezzat, Shahira M; Salem M.A.; Zayed A.; Salgado Castillo C.M.; Yazdi S.E.; Sen S.; Acharya K.; Sharopov F.; Martins N.; Student Research Committee; School of Medicine; Bam University of Medical Sciences; Bam; Iran; Zabol Medicinal Plants Research Center; Zabol University of Medical Sciences; Zabol; Iran; Instituto de EtnoFarmacolog�a; Facultad de Ciencias de la Salud; Universidad Arturo Prat; Avda. Arturo Prat 2120; Iquique; 1110939; Chile; Department of Chemical; Biological; Pharmaceutical and Environmental Sciences; University of Messina; Italy; Department of Pharmacognosy; Faculty of Pharmacy; Cairo University; Kasr El-Aini Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); 6th October 12566; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Menoufia University; Gamal Abd El Nasr st.; Shibin Elkom; Menoufia32511; Egypt; Department of Pharmacognosy; College of Pharmacy; Tanta University; Elguish Street; Tanta; 31527; Egypt; Facultad de Medicina; Universidad del Azuay; Cuenca; Ecuador; Department of Plant and Soil Sciences; University of PretoriaGauteng 0002; South Africa; Molecular and Applied Mycology and Plant Pathology Laboratory; Department of Botany; University of Calcutta; Kolkata; 700019; India; Department of Botany; Fakir Chand College; Diamond Harbour; West Bengal743331; India; Department of Pharmaceutical Technology; Avicenna Tajik State Medical University; Rudaki 139; Dushanbe; 734003; Tajikistan; Faculty of Medicine; University of Porto; Alameda Prof. Hernni Monteiro; Porto; 4200-319; Portugal; Institute for Research and Innovation in Health (i3S); University of Porto; Porto; 4200-135; Portugal
Background: Eucalyptus genus members have received a great interest worldwide for their antibacterial, antiviral, antifungal, anti-inflammatory and insect-repellent properties for cosmetic, pharmaceutical, nutraceutical and furniture purposes. Indeed, the application of Eucalyptus essential oil in cosmetic and personal hygiene products is gradually increasing. Also, it has been widely used in the traditional medicine for centuries, in the treatment of respiratory diseases, common cold, influenza, and sinus congestion. Scope and approach: This review addressed botanical and ethnopharmacological aspects of Eucalyptus plants, as also its in vitro and in vivo pharmacological activities, and current insights with regards to clinical efficacy and safety. Key findings and conclusions: Eucalyptol (1,8-cineole) is the main component present in Eucalyptus oils. According to the previously reported uses of Eucalyptus oils and extracts, there is urgently required further in vivo studies with the distinct Eucalyptus constituents to reveal the secrets beyond the traditional uses for treatment of a wide spectrum of ailments. A great attention has also been given for its nanotechnological applications by food and pharmaceutical industries. Nanoemulsions containing Eucalyptus globulus oil have been recognized for its antimicrobial and antibiofilm effects against gram-negative bacteria and the major microorganism responsible for causing fungal infections worldwide (Candida albicans). Moreover, eucalyptol does not present genotoxicity or carcinogenicity. Subacute hepatotoxic and nephrotoxic effects in animal models have been stated after application of high doses, higher than the estimated LD50 (2400 mg/kg b.w. In rats). However, an in-deep risk assessment on further exposure and toxicity data is highly needed. 2019 Elsevier Ltd
Looking at marine-derived bioactive molecules as upcoming anti-diabetic agents: A special emphasis on PTP1B inhibitors
(MDPI AG, 2018) Ezzat, Shahira M; El Bishbishy M.H.; Habtemariam S.; Salehi B.; Sharifi-Rad M.; Martins N.; Sharifi-Rad J.; Pharmacognosy Department; Faculty of Pharmacy; Cairo University; Kasr El-Ainy Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Science and Arts (MSA); Cairo; 12566; Egypt; Herbal Analysis Services UK; Pharmacognosy Research Laboratories; University of Greenwich; Central Avenue; Chatham-Maritime; Kent; ME4 4TB; United Kingdom; Student Research Committee; Bam University of Medical Sciences; Bam; 44340847; Iran; Department of Medical Parasitology; Zabol University of Medical Sciences; Zabol; 61663-335; Iran; Institute for Research and Innovation in Health (i3S); University of Porto; Porto; 4200-135; Portugal; Faculty of Medicine; University of Porto; Alameda Prof. Hern�ni Monteiro; Porto; 4200-319; Portugal; Zabol Medicinal Plants Research Center; Zabol University of Medical Sciences; Zabol; 61615-585; Iran; Department of Chemistry; Richardson College for the Environmental Science Complex; University of Winnipeg; 599 Portage Avenue; Winnipeg; MB R3B 2G3; Canada
Diabetes mellitus (DM) is a chronic metabolic disease with high morbimortality rates. DM has two types: type 1, which is often associated with a total destruction of pancreatic beta cells, and non-insulin-dependent or type 2 diabetes mellitus (T2DM), more closely associated with obesity and old age. The main causes of T2DM are insulin resistance and/or inadequate insulin secretion. Protein-tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling pathways and plays an important role in T2DM, as its overexpression may induce insulin resistance. Thus, since PTP1B may be a therapeutic target for both T2DM and obesity, the search for novel and promising natural inhibitors has gained much attention. Hence, several marine organisms, including macro and microalgae, sponges, marine invertebrates, sea urchins, seaweeds, soft corals, lichens, and sea grasses, have been recently evaluated as potential drug sources. This review provides an overview of the role of PTP1B in T2DM insulin signaling and treatment, and highlights the recent findings of several compounds and extracts derived from marine organisms and their relevance as upcoming PTP1B inhibitors. In this systematic literature review, more than 60 marine-derived metabolites exhibiting PTP1B inhibitory activity are listed. Their chemical classes, structural features, relative PTP1B inhibitory potency (assessed by IC50 values), and structure�activity relationships (SARs) that could be drawn from the available data are discussed. The upcoming challenge in the field of marine research�metabolomics�is also addressed. � 2018 by the authors.
Symphytum species: A comprehensive review on chemical composition, food applications and phytopharmacology
(2019) Salehi B.; Sharopov F.; Tumer T.B.; Ozleyen A.; Rodrguez-Prez C.; Ezzat S.M.; Azzini E.; Hosseinabadi T.; Butnariu M.; Sarac I.; Bostan C.; Acharya K.; Sen S.; Kasapoglu K.N.; Da?kaya-Dikmen C.; zelik B.; Baghalpour N.; Sharifi-Rad J.; Fokou P.V.T.; Cho W.C.; Martins N.; School of Medicine; Bam University of Medical Sciences; Bam; 44340847; Iran; Department of Pharmaceutical Technology; Avicenna Tajik State Medical University; Rudaki 139; Dushanbe; 734003; Tajikistan; Department of Molecular Biology and Genetics; Faculty of Arts and Science; Canakkale Onsekiz Mart University; Canakkale; 17020; Turkey; Graduate Program of Biomolecular Sciences; Institute of Natural and Applied Sciences; Canakkale Onsekiz Mart University; Canakkale; 17020; Turkey; Department of Nutrition and Food Science; University of Granada; Campus of Cartuja; Granada; E-18071; Spain; Institute of Nutrition and Food Technology (INYTA) 'Jos Mataix'; Biomedical Research Centre; University of Granada; Avenida del Conocimiento s/n; Granada; E-18071; Spain; Pharmacognosy Department; Faculty of Pharmacy; Cairo University; Kasr El-Ainy Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Science and Arts (MSA); 6th October; 12566; Egypt; Centre for Research on Food and Nutrition; Council for Agricultural Research and Economics; Rome; 546-00178; Italy; Department of Pharmacognosy and Biotechnology; School of Pharmacy; Shahid Beheshti University of Medical Sciences; Tehran; 11369; Iran; Banat's University of Agricultural Sciences and Veterinary Medicine King Michael I of Romania from Timisoara; Calea Aradului 119; Timis; 300645; Romania; Molecular and Applied Mycology and Plant Pathology Laboratory; Department of Botany; University of Calcutta; Kolkata; 700019; India; Department of Botany; Fakir Chand College; Diamond Harbour; West Bengal 743331; India; Istanbul Technical University; Chemical and Metallurgical Engineering Faculty; Food Engineering Department; Ayaza ga Campus; Maslak; Istanbul; 34469; Turkey; Istanbul Gedik University; Department of Gastronomy and Culinary Arts; Kartal; Istanbul; 34876; Turkey; Bioactive Research and Innovation Food Manufac.; Indust. Trade Ltd.; Katar Street; Teknokent ARI-3; B110; Sar?yer; Istanbul; 34467; Turkey; Phytochemistry Research Center; Shahid Beheshti University of Medical Sciences; Tehran; 11369; Iran; Zabol Medicinal Plants Research Center; Zabol University of Medical Sciences; Zabol; 61615-585; Iran; Antimicrobial and Biocontrol Agents Unit; Department of Biochemistry; Faculty of Science; University of Yaounde 1; Ngoa Ekelle; Annex Fac. Sci; Yaounde; 812; Cameroon; Department of Clinical Oncology; Queen Elizabeth Hospital; 30 Gascoigne Road; Hong Kong; Hong Kong; Faculty of Medicine; University of Porto; Alameda Prof. Hernni Monteiro; Porto; 4200-319; Portugal; Institute for Research and Innovation in Health (i3S); University of Porto; Porto; 4200-135; Portugal
Symphytum species belongs to the Boraginaceae family and have been used for centuries for bone breakages, sprains and rheumatism, liver problems, gastritis, ulcers, skin problems, joint pain and contusions, wounds, gout, hematomas and thrombophlebitis. Considering the innumerable potentialities of the Symphytum species and their widespread use in the world, it is extremely important to provide data compiling the available literature to identify the areas of intense research and the main gaps in order to design future studies. The present review aims at summarizing the main data on the therapeutic indications of the Symphytum species based on the current evidence, also emphasizing data on both the efficacy and adverse effects. The present review was carried out by consulting PubMed (Medline), Web of Science, Embase, Scopus, Cochrane Database, Science Direct and Google Scholar (as a search engine) databases to retrieve the most updated articles on this topic. All articles were carefully analyzed by the authors to assess their strengths and weaknesses, and to select the most useful ones for the purpose of review, prioritizing articles published from 1956 to 2018. The pharmacological effects of the Symphytum species are attributed to several chemical compounds, among them allantoin, phenolic compounds, glycopeptides, polysaccharides and some toxic pyrrolizidine alkaloids. Not less important to highlight are the risks associated with its use. In fact, there is increasing consumption of over-the-counter drugs, which when associated with conventional drugs can cause serious and even fatal adverse events. Although clinical trials sustain the folk topical application of Symphytum species in musculoskeletal and blunt injuries, with minor adverse effects, its antimicrobial potency was still poorly investigated. Further studies are needed to assess the antimicrobial spectrum of Symphytum species and to characterize the active molecules both in vitro and in vivo. 2019 by the authors.