Browsing by Author "Sakka, Ola K."

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    The utilization of 2-aminoprop-1-ene-1,1,3-tricarbonitrile as a precursor to quinoline, furan and thiophene derivatives with antitumor activities
    (WALTER DE GRUYTER & CO, 2011) Mohareb, Rafat M.; Fleita, Daisy H.; Sakka, Ola K.
    The condensation reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1) with 2-acetyl-furan (2) afforded 2-amino-4-(furan-2-yl)penta-1,3-diene-1,1,3-tricarbonitrile (3). The latter compound underwent a series of heterocyclization reactions to give quinoline, furan, pyrazole and thiophene derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Three of the synthesized compounds, namely 4, 5d and 12 showed high inhibitory effects.