Browsing by Author "Sabry, Omar M"

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    A new arsenal of polyphenols to make Parkinson's disease extinct: HPLC-MS/MS profiling, very interesting MAO-B inhibitory activity and antioxidant activity of Otostegia fruticosa
    (Taylor and Francis, 16/02/2022) Al-Madhagy, Somaia A; Gad, Sameh S; Mostafa, Eman S; Angelonie, Simone; Saad, Muhammed A; Sabry, Omar M; Caprioli, Giovani; El-Hawary, Seham S
    Fifteen compounds belong to phenolic acids, derivatives of phenolic acids, iridoids, xanthones and flavonoids were characterized in the methanolic extract of Otostegia fruticosa leaves using HPLC-MS/MS. Extract has been also investigated for its MAO-B inhibitory activity, antioxidant activity, total phenolic and total flavonoid content. The extract exhibited interesting MAO-B inhibitory activity (IC50; 2.24 ± 0.08) compared to the reference compound selegiline (0.55 ± 0.02 µg/mL). It also showed a potent antioxidant activity proven in both DPPH and ORAC assay methods. The extract showed an IC50 of 3.64 ± 1.22 µg/mL in the DPPH test which was significantly lower than that of the standard ascorbic acid which attained an IC50 of 18.3 ± 1.41 µg/mL. Moreover, in the oxygen radical absorbance capacity assay (ORAC) the extract showed a decline in the IC50 to 3.48 ± 1.16 µg/mL as compared to the standard Trolox which exhibited an IC50 of 27.0 ± 13.41.
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    A new firewall in the fight against breast cancer: in-vitro and in-silico studies correlating chemistry to apoptotic activity of Otostegia fruticosa
    (Taylor and Francis Ltd., 2022-10) Al-Madhagy, Somaia. A; Gad, Sameh S; Mostafa, Eman S; Angelonie, Simone; Saad, Muhammed A; Sabry, Omar M; Caprioli, Giovanni; El-Hawary, Seham S
    Breast cancer is the most devastating disease for women. There is a great demand for new sources to treat this disease. Medicinal plants are an indispensable source of bioactive compounds with wide range of pharmacological activities. In-vitro cytotoxic activity of Otostegia fruticosa methanolic extract against human breast cancer was studied using MCF-7 cell line. The extract showed mildly potent activity (IC50 ¼ 51 ± 9.836 mg/mL) in comparison to the standard anticancer doxorubicin (IC50 ¼ 7.467 ± 1.05 mg/mL). Potential compounds responsible for activity have been identified using Molecular Operating Environment (MOE) module on the major compounds detected by HPLC-MS/MS technique against estrogen alpha receptor (ERaþ: PDB ID 2JF9). 3,5-di-O-dicaffeoyl- quinic acid, hyperoside and rutin showed similar binding and antagonistic interaction with the estrogen alpha receptor as tam- oxifen in several poses. The retrieved results confirm that we can add this plant to a powerful arsenal that combats this insidious disease.
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    Therapeutic Potential of Pavetta L. Genus: An Updated Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects
    (NIDOC (Nat.Inform.Document.Centre), 2022-10) Al-Madhagy, Somaia. A; El-Hawary, Seham S; Sabry, Omar M; Gad, Sameh S; Mostafa, Eman S
    Pavetta L. genus is one of the largest genera in Rubiaceae family. Although of the wide distribution and the variety of traditional uses of it plants, research covered only limited species of Pavetta L. genus. The purpose of this review is to provide an in-depth understanding of traditional uses, phytochemical, pharmacological, and toxicological characteristics of these plants, which may lead to new insights into new therapeutic benefits of them. To achieve that, literatures without time limitation was used to gather information about all features of Pavetta L. genus including its botanical description and geographical distribution.
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    Therapeutic Potential of Pavetta L. Genus: An Updated Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicological Aspects
    (NIDOC (Nat.Inform.Document.Centre), 2023-02) Al-Madhagy, Somaia. A; El-Hawary, Seham S; Sabry, Omar M; Gad, Sameh S; Mostafa, Eman S
    Pavetta L. genus is one of the largest genera in Rubiaceae family. Although of the wide distribution and the variety of traditional uses of it plants, research covered only limited species of Pavetta L. genus. The purpose of this review is to provide an in-depth understanding of traditional uses, phytochemical, pharmacological, and toxicological characteristics of these plants, which may lead to new insights into new therapeutic benefits of them. To achieve that, literatures without time limitation was used to gather information about all features of Pavetta L. genus including its botanical description and geographical distribution. :