Browsing by Author "S. Gad, Sameh"

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    Effect of Ginger as Anti-Inflammatory Agent on Serum Nitric Oxide, Tumor Necrotic Factor α (TNF-α) and Interleukin 4 (IL-4) in Albino Rats with Carrageenan Induced Paw Edema
    (MEDWIN, 2018) S. Gad, Sameh
    Inflammation is a normal response of living tissues to injury. Inflammation is a general term that indicates the local accumulation of fluid, white blood cells, and plasma proteins. Inflammation is initiated by infection, physical injury, or some local immune response. It is the normal response from the body to protect tissue and promote recovery. Inflammation is a complex process performed through the body due to many internal and external factors, in order to achieve the best control of inflammatory diseases it is mandatory to see different approaches. Using natural products is a very good example. The present study represents a comparative study with the potency of Ginger against standard ordinary Indomethacin. 4 groups of animals were used each consist of 6 animals. Representing normal group, positive group, standard group (Indomethacin) and treated group (ginger). In the Fourth group (Treated group) pre-injection of Ginger (400 mg/kg; I.P.) 1 hour prior to carrageenan injection resulted in significant decrease in the blood serum contents of (TNF-α) to 40.9 Pg / ml and also result in significant decrease in Nitric Oxide (NO) value to 35.7 µmol/g tissue. This study has shown that ginger proved a significant anti-oedematogenic and anti-inflammatory activity on hind paw edema induced by carrageenan.
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    Silymarin and Curcumin has a Potential Hepato-Protective Effect against Chemically-Induced Liver Dysfunction
    (MEDWIN, 2017) S. Gad, Sameh
    The liver is important, essential, and vital organ in the body due to their function in body. Detection of hepatic dysfunction depends on the lab tests such as: Elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) and alkaline phosphatase (ALP). Curcumin has been shown to protect liver in much models of liver injury by inhibiting oxidative damage. Twenty four adult male albino rats their average weight 150-200 g were divided into four group six rats in each group ; group1: served as a normal group, group 2:subjected to 0.5mg/kg ccl4 dissolved in olive oil s.c every other day for 3 weeks, group 3:subjected to ccl40.5mg/kg dissolved in olive oil s.c every other day in addition to Curcumin 200 mg/kg /d orally every day for 3 weeks, group 4: subjected to ccl40.5 mg/kg dissolved in olive oil s.c every other day in addition to silymarin 200mg/kg orally every day for 3 weeks. The administration of ccl4 cause hepatic dysfunction and increase in serum ALT, AST and ALP level. The administration of Curcumin and silymarin along with ccl4 showed a decrease in serum ALT, AST and ALP level. The hepatic-protective effect of Curcumin and silymarin are relating to reduced liver enzymes as ALT, AST and ALP in hepatic dysfunction that produced by CCl4 toxicity through an antioxidant effects, exerting anti-inflammatory and free radical diminish.