Browsing by Author "Osama, Nada"

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Coriander (Coriandrum sativum L.) essential oil and oil‑loaded nano‑formulations as an anti‑aging potentiality viaTGFβ/SMAD pathway
(Springer nature, 2022-04) Salem, Mohamed A; Manaa, Eman G; Osama, Nada; Aborehab, Nora M; Ragab, Mai F; Haggag, Yusuf A; Ibrahim, Magda T; Hamdan, Dalia I
Aging has become a concern for many people, especially women. Given that high-quality anti-aging products are of high cost; it has imperative to search for other economical sources. Essential oils are frequently used in cosmetics products due to a wide range of biological activities as well as their pleasant odor. The current study aimed to investigate the biochemical efect of the cosmetic potential of selected Apiaceous essential oils, traditionally used for skincare, by evaluating their anti-wrinkle activity. It is worth noting that, coriander essential oil showed the highest collagenase, elastase, tyrosinase, and hyaluronidase inhibitory activities compared to other Apiaceous oils (fennel, anise, and cumin). GC–MS proved that coriander essential oil showed a very high level of oxygenated monoterpenes, with linalool (81.29%) as the most abundant constituent. Intriguingly, coriander oil cream and Coriander Essential Oil-loaded Lipid Nanoparticles (CEOLNs) formulations attenuated in vivo UV-induced skin photoaging that was manifested by signifcantly decreased MDA, COX-2, PGE- 2, MMP-1, JNK, and AP-1 levels. Moreover, these pharmaceutical dosage forms signifcantly increased skin collagen content compared to UV-injured group. Also, coriander essential oil signifcantly increased TGFβ, TGFβII, and SMAD3 protein expression levels compared to UV-injured group. In conclusion, the pharmaceutical dosage forms of coriander oil possess anti-wrinkle activities that could have an auspicious role in amending extrinsic aging.
Egyptian Handicrafts - ايادي من ذهب
(MSA university Faculty Of Mass Communication, 2021) Ahmed, Nadine; Osama, Nada; Tarek, Ibrahim
The journey of education is about to end and it feels great to grow up and move towards a new stage in life. Our deepest thanks and gratitude go to our parents and friends who have went with us through a lot, who were always there, supporting, helping, believing, and encouraging us to do the best we can. And here we are today, writing our graduation book which was an amazing, tiring but an earnest journey. Throughout our university experience, we got to meet the best people whom we are pleasured to have known. Starting with Dr. Hayat Badr, we are completely out of words. You are not just our instructor; you are a lot more than that. Thanks to everything you have done, and for your continuous support, cheerful words, and everything else that made us the successful graduates we are today. Moreover, thanks to our teacher assistant, Lama Atef, who also encouraged us to do our best and supported us through it all. We are grateful for your efforts with us and it was not easy.
Preparation and in vivo evaluation of nano sized cubosomal dispersion loaded with Ruta graveolens extracts as a novel approach to reduce asthma-mediated lung inflammation
(King Saud University, 2024-02) Alyami, Mohammad H; Hamdan, Dalia I; Khalil, Heba M.A; Orabi, Mohamed A.A; Aborehab, Nora M; Osama, Nada; Abdelhafez, Mai M; Al-Mahallawi, Abdulaziz Mohsen; Alyami, Hamad S
Asthma is a chronic disease affecting people of all ages. Asthma medications are associated with adverse effects restricting their long-term usage, demanding newer alternative therapies. This study aimed to investigate the anti-asthmatic properties of Ruta graveolens extract and its prepared nano-cubosomal dispersion (Ruta-ND). Firstly, the R. graveolens methanolic extract exhibited higher anti-inflammatory activity on Lipopolysaccharide (LPS)-activated BEAS-2B cells. To ensure best bioavailability and hence best cellular uptake, R. graveolens extract was loaded in nano-cubosomal dispersion (ND). Then, the anti-asthmatic effects of Ruta extract and ND were simultaneously evaluated in rats’ model with ovalbumin-induced allergic asthma. R. graveolens extract and RutaND subsided asthma score and improved lung function by restoring FEV1/FVC ratio to the expected values in control rats. Also, it showed strong antioxidant and anti-inflammatory activities manifested by lowering levels of malondialdehyde (MDA), IL-4, IL-7, TGF-β, and Ig-E, and increasing levels of superoxide dismutase (SOD) and INF-γ in bronchoalveolar lavage fluid. Our research findings also indicate autophagy induction and apoptosis inhibition by Ruta extract and Ruta-ND. Finally, the HPLC MS/MS phytochemical profiling of R. graveolens extract evident production of various alkaloids, flavonoids, coumarins, and other phenolics with reported pharmacological properties corresponding to/emphasize our study findings. In conclusion, R. graveolens exhibited promise in managing Ova-induced allergic asthma and could be developed as an alternative antiallergic asthma drug.