Browsing by Author "Nasr, Maha"

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    The beneficial activity of curcumin and resveratrol loaded in nanoemulgel for healing of burn-induced wounds
    (Elsevier, 1/21/2021) Alyoussef, Abdullah; El-Gogary, Riham I.; Ahmed, Rania F.; Farid, Omar AH.Ahmed; Bakeer, Rofanda M.; Nasr, Maha
    Burns are complicated wounds characterized by prolonged and persistent inflammatory phase. The combination of nutraceuticals in nano-delivery systems is hypothesized to enhance therapeutic efficacy and achieve better healing outcome. In this regard, we investigated the combination of two polyphenols; curcumin and resveratrol, in a nanoemulsion based gel system (nanoemulgel). The ex-vivo skin deposition of the prepared nanoemulgels was measured, and their in-vivo burn healing potential was tested in rat-burn induced model by measurement of inflammatory markers, oxidative stress markers, amino acids and vitamin E levels, in addition to histopathological examination. The particle size of the nanoemulsions ranged from 167-180 nm with PDI less than 0.4 and negative zeta potential (-17 to -20 mV). Remarkable retention of the nutraceuticals in the skin when loaded alone or combined in nanoemulgels, reaching ≈60% of the applied dose was shown after 48 hr. In vivo results proved the better burn healing outcome of the nanoemulgel formulation combining both curcumin and resveratrol, with histopathological features similar to normal control skin. Findings delineated the augmented burn healing potential of the nutraceuticals combination, and the promising delivery traits of the nanoemulgel dosage form, which can be further exploited with other nutraceuticals combinations.
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    Beneficial effects of curcumin nano-emulsion on spermatogenesis and reproductive performance in male rats under protein deficient diet model: enhancement of sperm motility, conservancy of testicular tissue integrity, cell energy and seminal plasma amino acids content
    (BioMed Central, 2017-12) Ahmed-Farid, Omar AH; Nasr, Maha; Ahmed, Rania F; Bakeer, Rofanda M
    Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence reproductive performance. The present study aimed to evaluate the effects of curcumin and curcumin nano-emulsion on protein deficient diet (PDD)-induced testicular atrophy, troubled spermatogenesis and decreased reproductive performance in male rats. Juvenile rats were fed the protein deficient diet (PDD) for 75 days. Starting from day 60 the rats were divided into 4 groups and given the corresponding treatments for the last 15 days orally and daily as follows: 1st group; curcumin group (C) received 50 mg/kg curcumin p.o. 2ndgroup; curcumin nano-form low dose group (NCL) received 2.5 mg/kg nano-curcumin. 3rd group; curcumin nano-form high dose group (NCH) received 5 mg/kg nano-curcumin. 4th group served as malnutrition group (PDD group) receiving the protein deficient diet daily for 75 days and received distilled water ingestions (5 ml/kg p.o) daily for the last 15 days of the experiment. A normal control group was kept under the same conditions for the whole experiment and received normal diet according to nutrition requirement center daily for 75 days and received distilled water ingestions (5 ml/kg p.o) daily for the last 15 days of the experiment. PDD induced significant (P < 0.05) reduction in serum testosterone level, sperm motility, testicular GSH, CAT, SOD, testicular cell energy (ATP, ADP and AMP), essential and non-essential amino acids in seminal plasma, an increase in testicular MDA, NOx, GSSG and 8-OHDG. Data was …
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    Biological and Pharmacological Characterization of Ascorbic Acid and Nicotinamide Chitosan Nanoparticles against insulin-Resistance-Induced Cognitive Defects:A Comparative Study
    (American Chemical Society, 2021-01) Abd-Allah, Hend; Nasr, Maha; Ahmed-Farid, OmarA.H; El-Marasy, Salma A; Bakeer, Rofanda M; Ahmed, Rania F
    High consumption of industrialized food with high fat content is generally associated with insulin resistance, which inturn causes memory impairment and cognitive decline