Browsing by Author "Mostafa E."

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    Acylated flavonol diglucosides from Ammania auriculata
    (Verlag der Zeitschrift fur Naturforschung, 2015) Nawwar M.; Ayoub N.; El-Raey M.; Zaghloul S.; Hashem A.; Mostafa E.; Eldahshan O.; Lindequist U.; Linscheid M.W.; National Research Center; Department of Phytochemistry and Plant Systematics; El Bohooth Str.; P.O. 12622; Dokki; Cairo; Egypt; Faculty of Pharmacy; Department of Pharmacognosy; Ain-Shams University; Cairo; Egypt; October University for Modern Sciences and Arts; 6th October City; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; Institute of Pharmacy; Pharmaceutical Biology; Ernst-Moritz-Arndt-Universit�t Greifswald; Greifswald; Germany; Laboratory of Applied Analytical and Environmental Chemistry; Department of Chemistry; Humboldt-Universit�t zu Berlin; Berlin; Germany
    Chemical investigation of the extract of the whole Ammania auriculata plant resulted in the identification of 13 polyphenols, including the hitherto unknown flavonoids, kaempferol 3-O-?-(6?-galloylglucopyranoside)- 7-O-?-glucopyranoside, and its quercetin analogue. The structures of all isolates were elucidated by conventional methods, spectroscopic analysis, including 1D and 2D NMR, and by HRESI-MS as well.
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    Centaurea pumilio L. extract and nanoparticles: A candidate for healthy skin
    (Elsevier B.V., 2019) Mostafa E.; Fayed M.A.A.; Radwan R.A.; Bakr R.O.; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); Giza; 11787; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; University of Sadat City; Egypt; Biochemistry and Biotechnology Department; Faculty of Pharmacy & Drug Technology; Heliopolis University; Cairo; Egypt
    Centaurea pumilio was the subject of phytochemical and biological studies, and its extract was used in the green synthesis of silver nanoparticles (AgNPs). Liquid chromatography/electrospray ionization mass spectrometry allowed the tentative identification of twenty-nine phytoconstituents of C. pumilio methanolic extract (CME), while column chromatography led to the identification of eight phenolic compounds. The neutral red uptake method showed the safety of CME and AgNPs on skin cells (HaCaT cell lines), while their high antioxidant potentials were demonstrated based on their oxygen radical absorbance capacity, and these results were confirmed in vivo. Additionally, CME and AgNPs had promising abilities to retard the ageing process and combat dark spots by potently inhibiting collagenase, elastase and tyrosinase, in addition to antimicrobial activity against skin infection-causing strains, especially Staphylococcus aureus, which was further confirmed by the significant phagocytic activity of neutrophils via engulfment. This study presents C. pumilio as a candidate for healthy skin. 2019 Elsevier B.V.