Browsing by Author "Moneim A.E.A."

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Antitumor potential of berberine and cinnamic acid against solid ehrlich carcinoma in mice
(Bentham Science Publishers B.V., 2019) Almeer R.S.; Aref A.M.; Hussein R.A.; Othman M.S.; Moneim A.E.A.; Department of Zoology; College of Science; King Saud University; Riyadh; Saudi Arabia; Faculty of Biotechnology; October University for Modern Science and Arts (MSA); Giza; Egypt; Department of Zoology and Entomology; Faculty of Science; Helwan University; Cairo; Egypt; Faculty of Preparatory year; University of Hail; Hail; Saudi Arabia
Background: Berberine and cinnamic acid are natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. Objective: In the present study, we aimed to investigate the proapoptotic potential of cinnamic acid and berberine in cancer cells by examining their effect on the expression of proapoptotic and antiapoptotic genes. Moreover, the effects of berberine and cinnamic acid on the antitumor activity of cisplatin were investigated in Ehrlich solid tumor-bearing mice. Methods: For the study, 90 male mice were inoculated intramuscularly with Ehrlich ascites tumor cells (2.5 � 106/mouse), and then on day 4, mice were randomly divided into six experimental groups (group 1-untreated Ehrlich solid tumor (EST), group 2-EST treated CDDP, group 3-EST treated CA, group 4-EST treated BER, group 5-EST treated CA + CDDP, and group 6-EST treated BER + CDDP). Result: The results showed that berberine and cinnamic acid significantly decreased tumor growth and tumor volume (- 74.8 and -75.5%, respectively) both as single agents and in combination with cisplatin. Moreover, both berberine and cinnamic acid increased the ratio of tumor growth inhibition (-91.5 and -92.6%, respectively), mean survival time (61.5 and 26 days, respectively), and percentage increase in lifespan (559 and 263%, respectively) of the treated mice. Our results also showed that both berberine and cinnamic acid-induced apoptosis by increasing the Bax/Bcl-2 ratio (74.1 and 45.1, respectively) and caspase-3 expression (14.3- and 11.6-fold increase, respectively). Additionally, berberine and cinnamic acid decreased oxidative stress markers, as shown by the decrease in lipid peroxidation and nitric oxide levels and an increase in reduced glutathione level. Conclusion: These results suggest that berberine and cinnamic acid have potential as antitumor and antioxidant agents derived from natural sources, which could be used alone or in combination with regular chemotherapeutic agents, such as cisplatin. These effects could be attributed to the proapoptotic activity of berberine and cinnamic acid. � 2019 Bentham Science Publishers.
Erratum to: Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress [BMC Complementary and Alternative Medicine, 16, (2016) (434)] DOI: 10.1186/s12906-016-1389-1
(BioMed Central Ltd., 2017) Al-Olayan E.M.; El-Khadragy M.F.; Alajmi R.A.; Othman M.S.; Bauomy A.A.; Ibrahim S.R.; Moneim A.E.A.; King Saud University; Chair vaccines research of infectious diseases; Faculty of Science; Riyadh; Saudi Arabia; King Saud University; Department of Zoology; Faculty of Science; Riyadh; Saudi Arabia; University of Helwan; Department of Zoology and Entomology; Faculty of Science; Cairo; Egypt; University of Hail; Faculty of Preparatory year; Hail; Saudi Arabia; October University for Modern Science and Arts (MSA); Faculty of Biotechnology; Giza; Egypt; Qassim University; Laboratory Sciences Dept.; College of Science and Arts; Al-Rass; Saudi Arabia; Molecular Drug Evaluation Department; National Organization for Drug Control and Research (NODCAR); Giza; Egypt
Following publication of the original article [1] it wasbrought to our attention that the affiliations for thisarticle had been incorrectly presented. Please notethat the correct affiliations should be as follows:Ebtesam M. Al-Olayan 1,2 , Manal F. El-Khadragy 1,2,3, Reem A. Alajmi 1 , Mohamed S. Othman 4,5 , Amira A.Bauomy 3,6 , Shaimaa R. Ibrahim 7 and Ahmed E. Abde l Moneim 3* 1 Chair vaccines research of infectious diseases, Facultyof Science, King Saud University, Riyadh, and KSA 2 Department of Zoology, Faculty of Science, King SaudUniversity, Riyadh, KSA 3 Department of Zoology and Entomology, Faculty ofScience, University of Helwan, Cairo, Egypt 4 Faculty of Preparatory year, University of Hail, Hail,KSA 5 Faculty of Biotechnology, October University forModern Science and Arts (MSA), Giza, Egypt 6 Laboratory Sciences Dept., College of Science andArts, Qassim University, Al-Rass, KSA 7 Molecular Drug Evaluation Department, NationalOrganization for Drug Control and Research (NODCAR),Giza, EgyptPlease also note that the Acknowledgements sectionshould be updated to the following: "The authors extendtheir appreciation to the Deanship of Scientific Researchat King Saud University for funding the work throughthe research group project No. RGPVPP-074". � The Author(s).
Oxidative stress and apoptosis are markers in renal toxicity following Egyptian cobra (Naja haje) envenomation
(University of Punjab (new Campus), 2014) Dkhil M.A.; Al-Quraishy S.; Farrag A.R.H.; Aref A.M.; Othman M.S.; Moneim A.E.A.; Department of Zoology; College of Science; King Saud University; Riyadh; Saudi Arabia; Department of Zoology and Entomology; Faculty of Science; Helwan University; Cairo; Egypt; Pathology Department; Medical Research Division; National Research Centre; Cairo; Egypt; Biological Science Department; Faculty of Dentistry; Modern Sciences and Arts University; Giza; Egypt; Biochemistry and Molecular Biology Department; Faculty of Biotechnology; Modern Science and Arts; Giza; Egypt
Snakebite is a serious and important problem in tropical and subtropical countries including Egypt. The venom of Egyptian cobra (Naja haje; L.) is complex, and it has been considered as a good source of short neurotoxins and several cytotoxins. In this study, oxidative stress inductions as well as apoptotic effects of the Egyptian cobra crude venom at a dose of 0.025mg/kg (intraperitoneal injection; i.p.) has been investigated in kidney of rats after 4 h. Twelve rats divided into 2 groups, Group I served as control group, Group II received i.p. injection of 0.025mg/kg of crude venom. The venom enhanced lipid peroxidation and nitric oxide productions in the kidney with concomitant reduction in glutathione content and superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities were inhibited. Moreover, the venom induced a renal injury as indicated by histopathological changes in the kidney tissue with an elevation in serum creatinine and urea. In addition, the renal ultrastructural changes were in the form of blebbing of visceral epithelial cells, and foot process disorganization. Also, the glomerular capillaries lined by hypertrophied endothelial cells. These findings were associated with the pro-apoptotic action in the kidney. The results suggest that Egyptian cobra venom stimulates oxidative stress to induce apoptosis in renal tissue through inhibition of mitochondrial respiration in male rats. Copyright 2014 Zoological Society of Pakistan.
The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity
(Elsevier Ltd, 2014) Dkhil M.A.; Al-Quraishy S.; Diab M.M.S.; Othman M.S.; Aref A.M.; Moneim A.E.A.; Department of Zoology; College of Science; King Saud University; Riyadh; Saudi Arabia; Department of Zoology and Entomology; Faculty of Science; Helwan University; Cairo; Egypt; Department of Molecular Drug Evaluation; National Organization for Drug Control and Research (NODCAR); Giza; Egypt; Department of Biochemistry and Molecular Biology; Faculty of Biotechnology; Modern Sciences and Arts (MSA); Giza; Egypt; Department of Biological Science; Faculty of Dentistry; Modern Sciences and Arts University (MSA); Giza; Egypt; Department of Biochemistry and Molecular Biology; Asturias Institute of Biotechnology; University of Oviedo; Oviedo; Spain
This study aimed to investigate the potential protective role of Physalis peruviana L. (family Solanaceae) against cadmium-induced hepatorenal toxicity in Wistar rats. Herein, cadmium chloride (CdCl2) (6.5mg/kg bwt/day) was intraperitoneally injected for 5 days, and methanolic extract of physalis (MEPh) was pre-administered to a group of Cd-treated rats by an oral administration at a daily dose of 200mg/kg bwt for 5 days. The findings revealed that CdCl2 injection induced significant decreases in kidney weight and kidney index. Cadmium intoxication increased the activities of liver enzymes and the bilirubin level, in addition to the levels of uric acid, urea and creatinine were increased in the serum. The pre-administration of MEPh alleviated hepatorenal toxicity in Cd-treated rats. Physalis was noted to play a good hepatorenal protective role, reducing lipid peroxidation, nitric oxide, and enhancing enzymatic activities and non-enzymatic antioxidant molecule, glutathione, in hepatic and renal tissues of Cd-treated rats. Moreover, physalis treatment was able to reverse the histopathological changes in liver and kidney tissues and also increased the expression of Bcl-2 protein in liver and kidney of rats. Overall, the results showed that MEPh can induce antioxidant and anti-apoptotic effects and also exerts beneficial effects for the treatment of Cd-induced hepatorenal toxicity. � 2014 Elsevier Ltd.