Browsing by Author "Mohamed A.A."

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Can zinc levels predict response to pegylated-interferon and ribavirin therapy in hepatitis c genotype 4 infected Egyptian patients?
(Universa Press, 2014) Mohamed A.A.; Abbassi M.M.; Hamed W.A.; Ezzel-Arab M.A.; Aref A.M.; Biochemistry Department; National Hepatology and Tropical Medicine Research Institute; Cairo; Egypt; Clinical Pharmacy Department; Cairo University; Cairo; Egypt; Tropical Medicine Department; Ain Shams University; Cairo; Egypt; Internal Medicine Department; National Hepatology and Tropical Medicine Research Institute; Cairo; Egypt; Biotechnology Department; MSA University; Cairo; Egypt
Background and Aims: Zinc has been found to be low in chronic hepatitis patients. Its level was correlated with response to Interferon/ribavirin therapy in patients infected with hepatitis C genotype 1. In Egypt, inexpensive predictors to treatment response in Hepatitis C genotype 4 infected patients are desperately needed. We aim to explore if pretreatment zinc serum levels correlate with response to pegylated- interferon and ribavirin therapy in Egyptian patients. Methods: This is an observational prospective study where 57 treatment na�ve hepatitis C genotype 4 infected patients that were Hepatitis B and Human Immunodeficiency virus negative were recruited in a hospital setting. The study was performed from October 2010 till June 2012. Patients had Liver biopsy and basic biochemical profiles were performed pretreatment for all patients. Treatment consisted of 48 weeks of pegylated-interferon-alpha2a and ribavirin therapy. Blood samples were withdrawn from 21 healthy subjects to compare zinc levels and other biochemical markers. Patients were followed up to 72 weeks. Results: Pretreatment serum zinc levels were significantly lower in hepatitis C infected patients compared to healthy volunteers (p < 0.05). Moreover, zinc levels correlated to sustained virological response in treated patients (p = 0.00). Conclusion: Serum zinc levels can be used as an inexpensive predictor to effective Pegylated-interferon/ribavirin therapy in Egyptian patients infected with Hepatitic C genotype 4.
Evaluation of circulating ADH and MIC-1 as diagnostic markers in Egyptian patients with pancreatic cancer
(Elsevier, 2015) Mohamed A.A.; Soliman H.; Ismail M.; Ziada D.; Farid T.M.; Aref A.M.; Al Daly M.E.; Abd Elmageed Z.Y.; Departments of Biochemistry; National Hepatology and Tropical Medicine Research Institute; Egypt; Department of Tropical Medicine and Infectious Diseases; Faculty of Medicine; Tanta University; Egypt; Departments of Surgery; National Hepatology and Tropical Medicine Research Institute; Egypt; Department of Clinical Biochemistry; Faculty of Medicine; King Abdel Aziz University; Jeddah; Saudi Arabia; Department of Biological Sciences; Faculty of Dentistry; Modern Science and Arts University; Egypt; Clinical Oncology; Faculty of Medicine; Cairo University; Egypt; Tulane University Health Sciences Center; Tulane University School of Medicine; 1430 Tulane Ave; New Orleans; LA; United States
Background Despite the incidence rate of pancreatic cancer (PC) is uncommon in developing countries, it is considered as one of the most lethal disease. Improving patients' survival requires diagnosis of the disease at early stage. Therefore, it is imperative to identify more specific and sensitive marker(s) to be used for early detection of PC. Objectives Our aim is to evaluate the potential role of circulating ADH and MIC-1 to be used as diagnostic markers in Egyptian patients and assess their value either alone or combined with CA19-9 in early detection of PC. Methods Alcohol dehydrogenase (ADH), macrophage inhibitory cytokine (MIC-1) and CA19-9 were measured by ELISA in serum procured from PC patients (n = 50) versus normal subjects (n = 20). Results Our results demonstrate that the circulating levels of ADH, MIC-1 and CA19-9 in blood of PC were significantly higher than in healthy controls (HCs) (p < 0.001). The highest marker sensitivity observed at early stage was MIC-1 (90%) and specificity was ADH (83%). The level of all three markers was elevated significantly in early stage of PC in comparison to HCs. The addition of ADH and MIC-1 to CA19-9 significantly improved the efficacy of diagnosis (p = 0.023). Conclusion Our data demonstrate that not only the combination of ADH and MIC-1 to CA19-9 can be used in early detection of PC but also can improve the overall quality of diagnosis of this lethal disease. � 2014 IAP and EPC.
The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity
(2010) Mohareb R.M.; Mohamed A.A.; Department of Organic Chemistry; Faculty of Pharmacy; October University for Modern Sciences and Arts; October City; AR; Egypt; Department of Chemistry; Faculty of Science; Cairo University; Giza; AR; Egypt; National Organization for Drug Control and Research (NODCAR); P.O. 29; Cairo; Egypt
New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.