Browsing by Author "Ibrahim S.M."

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Adiponectin and pro-inflammatory cytokines in obese diabetic boys
(2011) El-Mesallamy H.O.; Hamdy N.M.; Ibrahim S.M.; Biochemistry Department; Faculty of Pharmacy; Ain Shams University; Cairo; Egypt; Modern Sciences and Arts University; Cairo; Egypt
Adiponectin serum levels were significantly lower in obese diabetic than in non-obese healthy boys (P<0.001). Circulating soluble E-selectin levels was significantly higher in obese diabetic boys than the healthy non-obese (P<0.01). There were significant inverse correlations between adiponectin and sE-selectin, hsCRP, IL-1?, and MCP-1 and positively with NOx. We conclude that sE-selectin and MCP-1 may represent a link between obesity and related co-morbidities in children and adults.
Omentin and apelin concentrations in relation to obesity, diabetes mellitus type two, and cardiovascular diseases in Egyptian population
(Springer India, 2016) Abd-Elbaky A.E.; Abo-ElMatty D.M.; Mesbah N.M.; Ibrahim S.M.; Biochemistry Department; Port Said University; Port Said; Egypt; Biochemistry Department; Suez Canal University; Ismailia; Egypt; Biochemistry Department; Modern Sciences and Arts University; Cairo; Egypt
Dysregulation of omentin, a beneficial adipokine, and apelin, an inflammatory adipokine, is thought to play a role in the development of type 2 diabetes mellitus and cardiovascular disease. The objective of this study was to evaluate the relationship between circulating omentin and apelin concentrations and components of the metabolic syndrome in adults with and without type 2 diabetes mellitus or cardiovascular disease. A total of 240 adults, sex- and age-matched, were included in the current case�control study, including 80 healthy, non-obese controls, 80 obese patients with T2DM without cardiovascular disease, and 80 obese patients with T2DM with cardiovascular disease. A fasting blood sample was collected to determine biochemical indicators and insulin resistance index (HOMA-IR). Omentin, apelin, interleukin-1? (IL-1?), troponin-T, and oxidized LDL (Ox-LDL) plasma level was assessed by ELISA. Associations of adipokines with biochemical parameters of the patients were determined. Serum omentin levels were significantly lower and serum apelin and IL-1? concentrations were significantly higher in obese diabetic groups compared to non-obese controls. In correlation analyses, omentin negatively associated with the HOMA-IR index, apelin, and troponin-T, whereas apelin was positively associated with IL-1?, BMI, and troponin-T. Our study supports the hypothesis that abnormal production of omentin and apelin can contribute to the pathogenesis of obesity-related complications including T2DM and cardiovascular disease. � 2015, Research Society for Study of Diabetes in India.
The protective effect of Korean red ginseng against rotenone-induced parkinsons disease in rat model: Modulation of nuclear factor- and caspase-3
(Bentham Science Publishers, 2019) Zaafan M.A.; Abdelhamid A.M.; Ibrahim S.M.; Pharmacology & Toxicology Department; Faculty of Pharmacy; MSA University; Egypt; Biochemistry Department; Faculty of Pharmacy; MSA University; Egypt
Objective: Korean red ginseng was reported to have many biological effects like the antioxidant and the anti-inflammatory activities. Oxidative stress and neuro-inflammation play major roles in the pathogenesis of Parkinsons disease (PD). The current study aimed to investigate the protective effects of ginseng on rotenone-induced PD in rats. Methods: Rats were randomly allocated into 4 groups: Normal rats, rotenone control, ginseng+rotenone and ginseng only treated rats. The severity of PD was evaluated through locomotor activity perceived in the open field test, histological examination and immunohistochemical detection of amyloid-? in brain tissues, in addition to the biochemical assessment of tyrosine hydroxylase activity in brain tissues. Moreover, the following parameters were investigated for studying the possible mechanisms of ginseng neuroprotective effect: Nuclear factor-?? (NF-??), tumor necrosis factor-alpha (TNF-?), caspase- 3, lipid peroxides and reduced glutathione (GSH). Results: Ginseng exhibited potent neuroprotective effect that was reflected upon the histopathological examination, marked improvement in the locomotor activity and through its ability to suppress the amyloid-? deposition in the cortex and striatum along with significant increase in the tyrosine hydroxylase activity. Ginseng successfully inhibited the NF-?? inflammatory pathway in brain tissues beside the inhibition of other oxidative stress and inflammatory mediators. Furthermore, it exhibited antiapoptotic effect via the inhibition of caspase-3 expression. Conclusion: Ginseng could be a promising treatment in PD. It can suppress dopaminergic neuron degeneration through variable mechanisms mainly via inhibition of NF-?? pathway in addition to inhibition of oxidative stress and apoptosis. 2019 Bentham Science Publishers.