Browsing by Author "Habib M.S."

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    Macrophage migration inhibitory factor as an incriminating agent in vitiligo
    (Sociedade Brasileira de Dermatologia, 2018) Farag A.G.A.; Habib M.S.; Kamh M.E.; Hammam M.A.; Elnaidany N.F.; Dermatology; Andrology and STDs department; Faculty of Medicine; Menoufia UniversityEl Menoufia; Egypt; Medical Biochemistry department; Faculty of Medicine; Menoufia UniversityEl Menoufia; Egypt; Clinical Pharmacy department; Faculty of Pharmacy-MSA University; 6th October City; Egypt
    Background: Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in many autoimmune skin diseases. However, little is known about the contribution of this factor to vitiligo vulgaris. Objective: To determine the hypothesized role of migration inhibitory factor in vitiligo via estimation of serum migration inhibitory factor levels and migration inhibitory factor mRNA concentrations in patients with vitiligo compared with healthy controls. We also aimed to assess whether there is a relationship between the values of serum migration inhibitory factor and/ or migration inhibitory factor mRNA with disease duration, clinical type and severity in vitiligo patients. Methods: Evaluation of migration inhibitory factor serum level and migration inhibitory factor mRNA expression by ELISA and real-time PCR, respectively, were performed for 50 patients with different degrees of vitiligo severity and compared to 15 age- and gender-matched healthy volunteers as controls. Results: There was a highly significant increase in serum migration inhibitory factor and migration inhibitory factor mRNA levels in vitiligo cases when compared to controls (p<0.001). There was a significant positive correlation between both serum migration inhibitory factor and migration inhibitory factor mRNA concentrations in vitiligo patients, and each of them with duration and severity of vitiligo. In addition, patients with generalized vitiligo have significantly elevated serum migration inhibitory factor and mRNA levels than control subjects. Study limitations: Small number of investigated subjects. Conclusions: Migration inhibitory factor may have an active role in the development of vitiligo, and it may also be a useful index of disease severity. Consequently, migration inhibitory factor may be a new treatment target for vitiligo patients. � 2018 by Anais Brasileiros de Dermatologia.
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    Mean platelet volume: An immanent predictor of subclinical atherosclerosis in psoriatic patients compared with interleukin-1? and interleukin-6
    (Lippincott Williams and Wilkins, 2018) Farag A.G.A.; Zytoon A.A.; Habib M.S.; Elnaidany N.F.; Ibrahem R.A.L.; Salman S.; Mahfouz R.Z.; Department of Dermatology; Andrology and STDs; Faculty of Medicine; Menoufia University; Shebin El-Kom; Menoufia Governorate; 23511; Egypt; Department of Radiology; Faculty of Medicine; Egypt; Department of Medical Biochemistry; Faculty of Medicine; Egypt; Public Health and Community Medicine; Faculty of Medicine; Egypt; Department of Clinical Pathology; Menoufia University; Shebin El-Kom; Menoufia Governorate; Egypt; Department of Clinical Pharmacy; Faculty of Pharmacy; Modern Sciences and Arts University; 6th of October City; Giza Governorate; Egypt; Hematology and Oncology Research; Cleveland Clinic Lerner College of Medicine (CCLCM); Case Western University; Cleveland; OH; United States
    Background Mean platelet volume (MPV), may help to determine atherosclerosis threat. Cardiovascular disease is one of the common causes of morbidity and mortality in patients having psoriasis. Objective To examine MPV as a biomarker for subclinical atherosclerosis in psoriasis patients, compared with interleukin (IL)-1?, IL-6, and carotid intima media thickness (CIMT). Patients and methods Psoriatic patients (n=70) and age-matched and sex-matched healthy controls (n=60) were enrolled. Psoriasis Area and Severity Index score was used to assess psoriasis severity. For all enrolled participants; evaluation of MPV, IL-1?, and IL-6 serum levels, and measuring of CIMT were done. Results The mean values of MPV, IL-1, IL-6, and CIMT, all were significantly elevated in psoriatic patients than controls (P<0.05 for all). They were significantly correlated with each other (P<0.001), and with severity of psoriasis. Receiver operating characteristic curve analysis showed the possible validity of MPV for detection of subclinical atherosclerosis in psoriatic patients (sensitivity=90.9%, specificity=61.5%, accuracy=80%, area under the curve=0.82, P<0.001, 95% confidence interval=0.71-92) with 8.95 fl/ml as a cutoff value. Conclusion MPV is a good sensitive test for early prediction of atherosclerosis in psoriatic patients. We recommend a follow-up large scale study on psoriasis to examine the use of antiplatelets. � 2018 Egyptian Women's Dermatologic Society.