Browsing by Author "Fleita D.H."

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    Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity
    (2011) Mohareb R.M.; Fleita D.H.; Sakka O.K.; Department of Organic Chemistry; Faculty of Pharmacy; October University for Modern Sciences and Arts; October City; AR; Egypt; Department of Chemistry; Faculty of Science; Cairo University; Giza; AR; Egypt; Department of Chemistry; Faculty of Science; American University in Cairo; 5th Settlement; AR; Egypt
    The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.