Browsing by Author "Fayez, Ahmed"

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Characterization and Pharmacological Evaluation of Anti-Cellulite Herbal Product(s) Encapsulated in 3D-Fabricated Polymeric Microneedles
(nature, 2020-12) I.Amer, Reham ; El-Osaily, Ghada H.; Bakr, Riham Omar; El Dine, Riham Salah; Fayez, Ahmed
Skin health is vital for a healthy body. Herbal remedies have long been used for skin care, and their global use has tremendously increased over the past three decades. Although cellulite is seen as a normal condition by the medical community, it is considered a serious cosmetic concern for most afected women. Many topical anti-cellulite creams are available on the market, but unfortunately, their efcacy has not been proven scientifcally. Microneedles (MNs) represent a new approach to enhance the permeation of loaded medication through the skin. In this study, the anti-cellulite efects of Vitex agnus-castus and Tamarindus indica extracts were compared using safe and efective polymeric MNs. This delivery system ofers a painless alternative to the combined treatment strategy of microneedling devices and anti-cellulite products. The selected standardized extracts were evaluated for their mineral, phenolic and favonoid contents, which are correlated to a promising antioxidant efect, as demonstrated by an in vitro radical scavenging activity assay. 3D-printing techniques were chosen for fabrication of a micromold, which is inexpensive for mass production. To ensure that MNs were sufciently strong to perforate the skin without breaking, axial failure force was measured using a micro-mechanical test machine. The anticellulite efects of MNs were assessed using an in vivo diet- induced obesity guinea pig model. Skin properties, histopathology and infammatory markers were examined. MNs loaded with plant extracts were statistically comparable in normalizing the oxidative state and reducing infammation, while myeloperoxidase levels were more signifcantly reduced by T. indica than by V. agnus-castus. This novel delivery system opens the door for new transdermal strategies for cellulite management
Enhancement of the Solubility of Rosuvastatin Calcium by Nanovesicular Formulation: a Systematic Study Based on Quality by Design Approach
(MDPI, 2020-12) Dawoud, Marwa; Fayez, Ahmed; Ali, Reem; Sweed, Nabila
Rosuvastatin calcium (Rsv) is an effective statin, with a potent antihyperlipidemic effect. However, it suffers poor bioavailability owing to its poor solubility. Thus; encapsulating Rsv into a nanovesicular structure could overcome this problem. The aim of this work is to investigate the potential of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in enhancing the solubility of Rsv, using Quality by Design (QbD) concept. A complete risk assessment study has been conducted, where the critical process parameters (CPP), material attributes (MA), and critical quality attributes have been identified using the ishikawa diagrams. Selected CPP/MA were screened and further upgraded to a 24 full factorial design to develop the design space with the optimized formula. The screened CPP/MA were tested on each of the particle size, polydispersity index (PDI), zeta potential (ζ-pot) and the entrapment efficiency (EE%). A comprehensive approach for Rsv nanovesicular carriers has been conducted, where the NLC showed better results than the SLN. The optimized formula was prepared with 3% total lipid content, 0.154% surfactant, and 9.4 mg drug. The optimized formula had a particle size of 310.5 nm, with 0.243 PDI, a ζ-pot of −24.7 mV and EE% of 93.87%, and showed a sustained release of the drug up to 72 h. It successfully lowered each of the total cholesterol, low density lipoprotein, and triglycerides and elevated the level of the high density lipoprotein of the rats, with better results as compared to the standard drug. Thus, a complete QbD study was conducted to explore experimental regions for many successful nanovesicular carriers for the enhancement of the solubility of poorly soluble drugs.